Immune System News and Research

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Investigational treatment for ulcerative colitis (UC) and Crohn’s disease (CD) has Marketing Authorisation Application submitted

Takeda Pharmaceutical Company Limited (“Takeda”) today announced that a Marketing Authorisation Application (MAA) has been submitted to The European Medicines Agency (EMA) for vedolizumab, an investigational, gut-selective humanized monoclonal antibody for the treatment of adults with moderately to severely active ulcerative colitis (UC) and Crohn’s disease (CD), the two most common types of inflammatory bowel disease (IBD).

8 Mar 2013

New technology can turn off genes more precisely, say UCSF researchers

Scientists at UC San Francisco have found a more precise way to turn off genes, a finding that will speed research discoveries and biotech advances and may eventually prove useful in reprogramming cells to regenerate organs and tissues.

8 Mar 2013

APIC offers tips to stay infection-free

Beyond the obvious—steering clear of runny noses and hacking coughs—the Association for Professionals in Infection Control and Epidemiology (APIC) presents some other practical ways of staying infection-free.

8 Mar 2013

'Science Speaks' blog reports from 20th Conference on Retroviruses and Opportunistic Infections

The Center for Global Health Policy's "Science Speaks" blog on Wednesday published a series of posts on the 20th Conference on Retroviruses and Opportunistic Infections (CROI), which took place in Atlanta, Georgia, from Sunday to Wednesday.

8 Mar 2013

Study helps explain why viruses often spread through the brain in patchwork patterns

Viruses often spread through the brain in patchwork patterns, infecting some cells but missing others. New research at Washington University School of Medicine in St. Louis helps explain why. The scientists showed that natural immune defenses that resist viral infection are turned on in some brain cells but switched off in others.

8 Mar 2013

ADMA Biologics initiates enrollment in RI-002 Phase III study for PIDD

ADMA Biologics, Inc. (ADMA), a specialty immune globulin company that develops, manufactures and intends to market plasma-based biologics for the treatment and prevention of certain infectious diseases, announced that the first patient enrolled in the pivotal Phase III clinical study of its RI-002 has been dosed.

7 Mar 2013

Weekend reading: Deciding if it's 'time to let mom die,' a cancer hospital's controversial admission procedures

My father, sister and I sat in the near-empty Chinese restaurant, picking at our plates, unable to avoid the question that we'd gathered to discuss: When was it time to let Mom die? ... My father and sister looked to me for my thoughts. In our family, after all, I'm the go-to guy for all things medical. I've been a health care reporter for 15 years: at the Dallas Morning News, the Los Angeles Times and now ProPublica.

7 Mar 2013

RA patients who initiate anti-TNF therapies do not have higher risk of shingles: Study

Although patients with rheumatoid arthritis have a disproportionately higher incidence of herpes zoster (shingles), an analysis that included nearly 60,000 patients with RA and other inflammatory diseases found that those who initiated anti-tumor necrosis factor therapies were not at higher risk of herpes zoster compared with patients who initiated nonbiologic treatment regimens, according to a study appearing in the March 6 issue of JAMA.

7 Mar 2013

Study reveals increased dietary salt intake may lead to autoimmune disorders

Increased dietary salt intake can induce a group of aggressive immune cells that are involved in triggering and sustaining autoimmune diseases.

7 Mar 2013

Insight into how Th17 cell growth influences development of immune responses

New work from the Broad Institute's Klarman Cell Observatory, Brigham and Women's Hospital, Harvard University, MIT, and Yale University expands the understanding of how one type of immune cell - known as a T helper 17 or Th17 cell - develops, and how its growth influences the development of immune responses.

7 Mar 2013

Study investigates how cancer cells 'hijack' platelets

A new research study has investigated how cancer cells 'hijack' blood cells known as platelets, enabling cancer to spread around the body and promoting the growth of new tumours, it was reported today at the annual Royal College of Surgeons in Ireland (RCSI) Research Day.

7 Mar 2013

Salt can induce and worsen pathogenic immune system responses in mice

For the past few decades, health officials have been reporting increases in the incidence of autoimmune diseases such as multiple sclerosis (MS). Now researchers at Yale School of Medicine, Harvard Medical School and the Broad Institute have identified a prime suspect in the mystery - dietary salt.

7 Mar 2013

Study combines induced pluripotent stem cell technology and genetic correction to treat DMD

Researchers at the University of Minnesota's Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).

7 Mar 2013

Study shows how fish oils help lower blood pressure via vasodilation at ion channels

Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems.

6 Mar 2013

Chemotherapy-free stem cell transplant shows promise for sickle cell disease

Two brothers have been cured of their sickle cell disease at the University of Illinois Hospital & Health Sciences System using a relatively uncommon type of stem cell transplant that is performed without chemotherapy.

6 Mar 2013

Aerobic walking program alleviates lower back pain, says Tel Aviv University researcher

Lower back pain is a common complaint, and treatment often requires many hours of physical therapy over multiple weekly clinic visits - a costly commitment.

6 Mar 2013

New research findings could lead to development of effective therapies for anxiety disorders

Researchers at Boston University School of Medicine have, for the first time, identified a specific group of cells in the brainstem whose activation during rapid eye movement sleep is critical for the regulation of emotional memory processing.

6 Mar 2013

SIRT1 gene may be involved in development of type 1 diabetes

A JDRF-funded study out of Switzerland has shown that a single gene called SIRT1 may be involved in the development of type 1 diabetes (T1D) and other autoimmune diseases. The study, "Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes," was published today in Cell Metabolism and represents the first demonstration of a monogenetic defect leading to the onset of T1D.

6 Mar 2013

Scientists decode the antihypertensive impact of omega-3 fatty acids

Scientists of Friedrich Schiller University Jena and Jena University Hospital decode the antihypertensive impact of omega-3 fatty acids. In two newly published articles for the well-known science magazine 'Proceedings of the National Academy of Sciences, USA' they describe how they analyzed the impact of omega-3 fatty acids on a systemic level and they also described the underlying molecular mechanisms for the first time.

6 Mar 2013

National Jewish Health receives U.S. patent for POPG and related compounds

Dennis Voelker, PhD, professor of medicine at National Jewish Health, has been awarded a U.S. patent (#8,367,643) for various lipids and related compounds that can inhibit inflammation and infection in the lungs, especially those caused by influenza and respiratory syncytial virus (RSV).

5 Mar 2013

Immune System News and Research

Investigational treatment for ulcerative colitis (UC) and Crohn’s disease (CD) has Marketing Authorisation Application submitted

New technology can turn off genes more precisely, say UCSF researchers

APIC offers tips to stay infection-free

'Science Speaks' blog reports from 20th Conference on Retroviruses and Opportunistic Infections

Study helps explain why viruses often spread through the brain in patchwork patterns

ADMA Biologics initiates enrollment in RI-002 Phase III study for PIDD

Weekend reading: Deciding if it's 'time to let mom die,' a cancer hospital's controversial admission procedures

RA patients who initiate anti-TNF therapies do not have higher risk of shingles: Study

Study reveals increased dietary salt intake may lead to autoimmune disorders

Insight into how Th17 cell growth influences development of immune responses

Study investigates how cancer cells 'hijack' platelets

Salt can induce and worsen pathogenic immune system responses in mice

Study combines induced pluripotent stem cell technology and genetic correction to treat DMD

Study shows how fish oils help lower blood pressure via vasodilation at ion channels

Chemotherapy-free stem cell transplant shows promise for sickle cell disease

Aerobic walking program alleviates lower back pain, says Tel Aviv University researcher

New research findings could lead to development of effective therapies for anxiety disorders

SIRT1 gene may be involved in development of type 1 diabetes

Scientists decode the antihypertensive impact of omega-3 fatty acids

National Jewish Health receives U.S. patent for POPG and related compounds

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