Anemia News and Research

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Anemia is a decrease in normal number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few.

Novartis receives EC approval for Jakavi to treat myelofibrosis

Incyte Corporation today announced that its strategic collaborator, Novartis, received approval from the European Commission for Jakavi (INC424, ruxolitinib), an oral JAK 1 and JAK 2 inhibitor discovered by Incyte, for the treatment of disease-related splenomegaly or symptoms in adult patients with primary myelofibrosis (also known as chronic idiopathic myelofibrosis), post-polycythemia vera myelofibrosis or post-essential thrombocythemia myelofibrosis.

28 Aug 2012

New results describe development of DC cancer vaccine with enhanced immunogenic potential

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, and collaborators at Radboud University Nijmegen Medical Centre in the Netherlands announced today that they have published new pre-clinical results in the journal Cancer Immunology Immunotherapy describing the development of a dendritic cell (DC) cancer vaccine with enhanced immunogenic potential.

23 Aug 2012

Study finds 'inconclusive' evidence to support use of WHO-backed drug to prevent hemorrhage during labor

"The World Health Organization [WHO] should review its approval of a drug used to prevent life-threatening bleeding in women in childbirth because there is not enough evidence that it is effective," according to a study published Monday in the Journal of the Royal Society of Medicine, Reuters reports.

22 Aug 2012

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage.

17 Aug 2012

Study tracks effects of heavy PAE on growth and body composition throughout childhood

Although studies of alcohol's effects on fetal growth have consistently demonstrated deficits that persist through infancy, the data on long-term postnatal growth from human studies have been inconsistent. A new study of the effects of heavy prenatal alcohol exposure (PAE) on growth and body composition throughout childhood has found growth restrictions that persist through to nine years of age, as well as a delay in weight gain during infancy, both of which were exacerbated by iron deficiency.

16 Aug 2012

Researchers discover why people with sickle cell disease get milder cases of malaria

Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells.

16 Aug 2012

HAS-BLED proves predictive ability

Researchers say that the HAS-BLED score is a significant predictor for intracranial hemorrhage when compared with the HEMORR2HAGES and ATRIA scores, supporting international guideline recommendations.

14 Aug 2012

‘Low’ toxicity for phase I cancer trials

Advanced cancer patients participating in phase I clinical trials at the University of Texas MD Anderson Cancer Center experienced a low rate of toxicity, researchers say.

13 Aug 2012

Endocrine Society revises clinical practice guideline for management of thyroid dysfunction

The Endocrine Society has made revisions to its 2007 Clinical Practice Guideline (CPG) for management of thyroid disease during pregnancy and postpartum. The CPG provides recommendations for diagnosis and treatment of patients with thyroid-related medical issues just before and during pregnancy and in the postpartum interval.

12 Aug 2012

Combination therapy does not change safety and efficacy relationship of TORISEL for advanced RCC

Pfizer Inc. announced that the Phase 3 INTORACT trial (B1771006), evaluating the combination of bevacizumab plus TORISEL (temsirolimus) compared with bevacizumab plus interferon-alfa-2a (IFN-α-2a) in the first-line treatment of patients with advanced renal cell carcinoma (RCC) across risk groups, did not meet its primary endpoint of superiority in extending progression free survival (PFS) in the study population.

12 Aug 2012

Medicare payments for anemia drug too high; Feds seek fix to glitch that denies some hospitalized beneficiaries coverage for follow-up nursing home care

The U.S. health-care system is vastly overspending for a single anemia drug because Medicare overestimates its use by hundreds of millions of dollars a year, according to an analysis of federal data. The overpayment to hospitals and clinics arises because Medicare reimburses them based on estimates rather than the actual use of the drug.

12 Aug 2012

First Edition: August 10, 2012

Reporting for Kaiser Health News, in collaboration with The Washington Post, Susan Jaffe writes: "Concerned that a growing number of seniors have been unexpectedly forced to pay thousands of dollars for nursing home care after a stay in a hospital, Medicare has launched a pilot project to test whether relaxing its hospital payment rules could help beneficiaries".

10 Aug 2012

Anemia prevention in pregnancy: an interview with Juan Pablo Peña-Rosas, WHO

Anaemia is a condition in which the number of red blood cells in the body is lower than normal or these have lower amounts of haemoglobin, a protein that is involved in the oxygen exchange of the body.

10 Aug 2012

Researchers identify how telomerase is recruited to chromosome ends

Stem cells are special. Nestled in muscle and skin, organ and bone, they bide their time over years or decades until called to replace damaged or lost tissue. One secret to their longevity is an enzyme called telomerase, which stills the relentless ticking of the molecular clock that limits the life span of other cells.

3 Aug 2012

FibroGen receives FDA Orphan Drug Designation for FG-3019 to treat IPF

FibroGen, Inc., today announced that FG-3019, the Company's human monoclonal antibody against connective tissue growth factor (CTGF), has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the treatment of idiopathic pulmonary fibrosis (IPF).

31 Jul 2012

Progress with GSK in advancing VaxiRNA technology earns Alnylam $3.2M milestone payment

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has earned a development milestone payment from GlaxoSmithKline, totaling $3.2 million. The milestone payment is related to progress in the companies' collaboration on the use of VaxiRNA technology for the production of GSK influenza vaccine.

30 Jul 2012

FDA grants priority review to GSK’s Promacta sNDA for treatment of thrombocytopenia

Ligand Pharmaceuticals Incorporated today announced that its partner GlaxoSmithKline has been granted priority review from the US Food and Drug Administration for the supplemental new drug application for Promacta to treat thrombocytopenia in adult patients with chronic hepatitis C virus (HCV) infection.

26 Jul 2012

HemoGlobe device can identify women with anemia

Could a low-cost screening device connected to a cell phone save thousands of women and children from anemia-related deaths and disabilities? That's the goal of Johns Hopkins biomedical engineering undergraduates who've developed a noninvasive way to identify women with this dangerous blood disorder in developing nations. The device, HemoGlobe, is designed to convert the existing cell phones of health workers into a "prick-free" system for detecting and reporting anemia at the community level.

25 Jul 2012

Bioniche receives U.S. and Canadian approval for first of two canine oncology products

Bioniche Life Sciences Inc., a research-based, technology-driven Canadian biopharmaceutical company, today announced that the first of two canine oncology products has received approval by regulators in both the U.S. and Canada.

24 Jul 2012

When checks and balances in the pharmaceutical marketplace fall short

The Washington Post explores how a trio of very expensive anemia drugs became "superstars" in the marketplace. Also, The Wall Street Journal tracks the process by which certain fake cancer drugs found their way into the United States.

21 Jul 2012

Anemia News and Research

Further Reading

Novartis receives EC approval for Jakavi to treat myelofibrosis

New results describe development of DC cancer vaccine with enhanced immunogenic potential

Study finds 'inconclusive' evidence to support use of WHO-backed drug to prevent hemorrhage during labor

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Study tracks effects of heavy PAE on growth and body composition throughout childhood

Researchers discover why people with sickle cell disease get milder cases of malaria

HAS-BLED proves predictive ability

‘Low’ toxicity for phase I cancer trials

Endocrine Society revises clinical practice guideline for management of thyroid dysfunction

Combination therapy does not change safety and efficacy relationship of TORISEL for advanced RCC

Medicare payments for anemia drug too high; Feds seek fix to glitch that denies some hospitalized beneficiaries coverage for follow-up nursing home care

First Edition: August 10, 2012

Anemia prevention in pregnancy: an interview with Juan Pablo Peña-Rosas, WHO

Researchers identify how telomerase is recruited to chromosome ends

FibroGen receives FDA Orphan Drug Designation for FG-3019 to treat IPF

Progress with GSK in advancing VaxiRNA technology earns Alnylam $3.2M milestone payment

FDA grants priority review to GSK’s Promacta sNDA for treatment of thrombocytopenia

HemoGlobe device can identify women with anemia

Bioniche receives U.S. and Canadian approval for first of two canine oncology products

When checks and balances in the pharmaceutical marketplace fall short

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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