Animal Model News and Research

RSS

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

US-Australian drug discovery company, Novogen Limited, today announced details of an in vivo proof of concept study that demonstrates their lead anti-tropomyosin drug candidate, Anisina, has the potential to improve the effectiveness of chemotherapy in children and reduce life-long side-effects.

14 Jul 2015

New research identifies potential treatment for primary effusion lymphoma

New research from the University of Southern California Norris Comprehensive Cancer Center has identified a potential treatment for a rare but previously incurable form of lymphoma that is observed primarily in patients with HIV/AIDS infection.

8 Jul 2015

Researchers pinpoint two biomarkers elevated in severe form of coronary disease

Insulin resistance affects tens of millions of Americans and is a big risk factor for heart disease. Yet, some people with the condition never develop heart disease, while some experience moderate coronary blockages. Others, though, get severe atherosclerosis - multiple blockages and deterioration of coronary arteries characterized by thick, hard, plaque-ridden arterial walls.

7 Jul 2015

New portable system can produce life-saving NO from air by means of electrical spark

Treatment with inhaled nitric oxide (NO) has proven to be life saving in newborns, children and adults with several dangerous conditions, but the availability of the treatment has been limited by the size, weight and complexity of equipment needed to administer the gas and the therapy's high price.

7 Jul 2015

Research finding could lead to first effective therapies, vaccines against dengue virus

Researchers at Vanderbilt University and the National University of Singapore have determined the structure of a human monoclonal antibody which, in an animal model, strongly neutralizes a type of the potentially lethal dengue virus.

3 Jul 2015

Wayne State University awarded grant to explore new MS pathology model

The National Multiple Sclerosis Society has provided a grant to a Wayne State University School of Medicine professor to explore a new model of MS pathology.

2 Jul 2015

Subcutaneous administration increases tolerability of multispecific antibody tumor treatment

Tumor treatment with multispecific antibodies is significantly more tolerable if administered subcutaneously rather than via the bloodstream, which was the standard procedure until now. This was the result of an animal model study undertaken by researchers at Helmholtz Zentrum München in cooperation with the Munich biotech company Trion Research.

1 Jul 2015

Nanoparticles packed with chemotherapy drug and coated with chitosan target cancer stem-like cells

Nanoparticles packed with a clinically used chemotherapy drug and coated with an oligosaccharide derived from the carapace of crustaceans might effectively target and kill cancer stem-like cells, according to a recent study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

1 Jul 2015

NIBIB-supported researchers create platelet-like particles to control excessive bleeding, augment clotting

NIBIB-supported researchers have created tiny gel particles that can perform the same essential functions as platelets. The particles could one day be used to control excessive bleeding following traumatic injury or in individuals with impaired clotting due to an inherited condition or as a result of certain medications or chemotherapy.

1 Jul 2015

TSRI scientists find five different miRNAs involved in memory formation

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that a type of genetic material called “microRNA” plays surprisingly different roles in the formation of memory in animal models. In some cases, these RNAs increase memory, while others decrease it.

30 Jun 2015

SLU's Center for Vaccine Development receives $2.9 million to study new vaccine to combat TB

Saint Louis University's Center for Vaccine Development has received a $2.9 million award from the Bill & Melinda Gates Foundation to study a new tuberculosis vaccine.

30 Jun 2015

Study could point the way to new treatments for people with severe asthma

The immune response that occurs in patients with severe asthma is markedly different than what occurs in milder forms of the lung condition, according to researchers from the University of Pittsburgh School of Medicine. Those unique features could point the way to new treatments, they said in an article published online today in the Journal of Clinical Investigation.

30 Jun 2015

Tiny aquatic flatworms could replace existing animal models used in neurotoxicity tests

Laboratories that test chemicals for neurological toxicity could reduce their use of laboratory mice and rats by replacing these animal models with tiny aquatic flatworms known as freshwater planarians.

29 Jun 2015

Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

Neuralstem, Inc., a biopharmaceutical company using neural stem cell technology to develop small molecule and cell therapy treatments for central nervous system diseases, announced that the poster "Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer's Disease" was presented yesterday at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Stockholm, Sweden.

27 Jun 2015

Animal study highlights major safety concern regarding use of MRI contrast agents in patients

New results in animals highlight a major safety concern regarding a class of magnetic resonance imaging (MRI) contrast agents used in millions of patients each year, according to a paper published online by the journal Investigative Radiology.

26 Jun 2015

Researchers use different approaches to test ways to manipulate nanoparticles in medicine

Nanoparticles are the smallest particles capable of reaching virtually all parts of the body. Researchers use various approaches to test ways in which nanoparticles could be used in medicine - for instance, to deliver substances to a specific site in the body such as a tumor.

22 Jun 2015

Experimental AIDS vaccine candidate stimulates immune system to block infection in animal model

New research led by scientists at The Scripps Research Institute, International AIDS Vaccine Initiative and The Rockefeller University shows that an experimental vaccine candidate can stimulate the immune system to block HIV infection in mice.

18 Jun 2015

MGH researchers develop new approach to skin rejuvenation

A new approach to skin rejuvenation developed at Massachusetts General Hospital (MGH) may be less likely to have unintended side effects such as scarring and altered pigmentation.

18 Jun 2015

Helmholtz Zentrum München scientists investigating molecular causes of COPD

At present, there is a lack of effective treatments that target the causes of chronic obstructive pulmonary disease (COPD). Scientists of the Comprehensive Pneumology Center at Helmholtz Zentrum München are therefore investigating the molecular causes of COPD in order to intervene specifically.

17 Jun 2015

Laurent reports positive topline results from LAU-7b Phase 1b trial in adult CF patients

Laurent Pharmaceuticals Inc. announced today positive topline results from a Phase 1b clinical trial with LAU-7b in adult CF patients. LAU-7b is a novel oral formulation of fenretinide, a synthetic retinoid investigated for its lipid modulating properties and potential to address the aberrant inflammatory response in CF.

15 Jun 2015

Animal Model News and Research

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

New research identifies potential treatment for primary effusion lymphoma

Researchers pinpoint two biomarkers elevated in severe form of coronary disease

New portable system can produce life-saving NO from air by means of electrical spark

Research finding could lead to first effective therapies, vaccines against dengue virus

Wayne State University awarded grant to explore new MS pathology model

Subcutaneous administration increases tolerability of multispecific antibody tumor treatment

Nanoparticles packed with chemotherapy drug and coated with chitosan target cancer stem-like cells

NIBIB-supported researchers create platelet-like particles to control excessive bleeding, augment clotting

TSRI scientists find five different miRNAs involved in memory formation

SLU's Center for Vaccine Development receives $2.9 million to study new vaccine to combat TB

Study could point the way to new treatments for people with severe asthma

Tiny aquatic flatworms could replace existing animal models used in neurotoxicity tests

Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

Animal study highlights major safety concern regarding use of MRI contrast agents in patients

Researchers use different approaches to test ways to manipulate nanoparticles in medicine

Experimental AIDS vaccine candidate stimulates immune system to block infection in animal model

MGH researchers develop new approach to skin rejuvenation

Helmholtz Zentrum München scientists investigating molecular causes of COPD

Laurent reports positive topline results from LAU-7b Phase 1b trial in adult CF patients

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

Latest News