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JAX wins $30 million contract to create computational "digital twins" of the human heart

Developing new drugs is one of the riskiest and most expensive endeavors in science. Today, The Jackson Laboratory (JAX) announced a bold initiative to improve that trajectory, powered by an up to $30 million contract from the Advanced Research Projects Agency for Health (ARPA-H) Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST) program.

8 Dec 2025

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

It's not often that a pathologist gets to make a diagnosis that works for the patient by preventing treatment from occurring.

8 Dec 2025

Social media affects children's ability to concentrate, study reveals

Children who spend a significant amount of time on social media tend to experience a gradual decline in their ability to concentrate.

8 Dec 2025

Chemotherapy-free combination treatment outperforms traditional regimens in patients with Ph+ ALL

A chemotherapy-free combination treatment outperformed a combination of targeted therapy and chemotherapy among patients with Ph+ acute lymphoblastic leukemia (ALL) in a new study.

7 Dec 2025

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

7 Dec 2025

Black patients with AML experience earlier onset and poorer outcomes

Compared with white patients, Black patients with acute myeloid leukemia (AML) were on average more than five years younger at diagnosis, more than 30% more likely to die of their disease, and more than 20% more likely to die of any cause, according to an analysis of data conducted over a 34-year period and supported by the National Cancer Institute (NCI) is a component of the U.S. National Institutes of Health.

7 Dec 2025

Exa-cel shows complete success in early pediatric trials for sickle cell disease and beta-thalassemia

Preliminary results from two trials of the gene therapy exagamglogene autotemcel (exa-cel) suggest the therapy offers an effective cure for beta-thalassemia and sickle cell disease in children younger than 12.

6 Dec 2025

WHO Member States push forward toward a unified Pathogen Access and Benefit Sharing system

WHO Member States today ended their latest round of intensive negotiations on the world's first Pathogen Access and Benefit Sharing (PABS) system.

6 Dec 2025

New Lancet series blends social science with medicine to tackle global health inequities

Can doctors in California learn from a patient who was bounced from one specialist to another in Japan? Can clinicians in London take lessons from a patient seeking asylum while suffering a medical emergency at the U.S.-Mexico border? Can doctors treating refugees in Africa inform health policy around the world?

5 Dec 2025

Genetic variant linked to higher heart failure risk in children with myocarditis

A genetic variant is likely putting some children suffering with myocarditis - inflammation of the heart muscle - at higher risk of developing heart failure, which can be fatal, according to a study published today in Circulation Heart Failure.

5 Dec 2025

Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common present-day chemicals could explain why some women are more likely to develop endometriosis.

5 Dec 2025

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis.

4 Dec 2025

Bacterial enzyme linked to heart complications in pneumonia

Pneumonia is a disease that burdens the healthcare system with more that 1.2 million emergency room visits each year and more than 41,000 adult deaths in the United States.

4 Dec 2025

Scientists uncover why SETX-deficient cancer cells rely on error-prone DNA repair

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break-when both sides of the DNA helix are cut at once.

4 Dec 2025

New drug combination shows promise for overcoming resistance in ovarian cancer

Researchers at the University of Colorado Cancer Center have discovered a novel therapy combination that could offer new hope to ovarian cancer patients who do not respond to existing treatments.

4 Dec 2025

Common childhood virus linked to bladder cancer later in life

Tackling a common childhood virus could open the door to preventing bladder cancer, according to new research funded by Kidney Research UK and York Against Cancer.

4 Dec 2025

Wind-borne mosquitoes carry infectious pathogens for hundreds of miles

High-flying mosquitoes in West Africa are carriers of multiple pathogens, including West Nile virus, highlighting risks in vector-borne disease management.

4 Dec 2025

Retinal organoids provide a powerful tool to diagnose and study Leber congenital amaurosis

Leber Congenital Amaurosis (LCA) is an inherited retinal disease leading to severe vision impairment from early infancy, affecting 2-3 out of every 100,000 newborns. LCA is caused by variants in certain genes from which proteins essential for retinal cell function and survival are made.

3 Dec 2025

Poor kidney function associated with elevated Alzheimer’s markers in the blood

People with impaired kidney function have higher levels of Alzheimer's biomarkers in their blood, but not an increased risk of dementia, according to a study published December 3, 2025, in Neurology®, the medical journal of the American Academy of Neurology.

3 Dec 2025

New rapid test distinguishes real HIV infections from vaccine-related false positives

Since the human immunodeficiency virus (HIV) was identified in 1983, roughly 91.4 million people around the world have contracted the virus and an additional 44.1 million have died from related causes.

3 Dec 2025

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Genetic News and Research

JAX wins $30 million contract to create computational "digital twins" of the human heart

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

Social media affects children's ability to concentrate, study reveals

Chemotherapy-free combination treatment outperforms traditional regimens in patients with Ph+ ALL

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

Black patients with AML experience earlier onset and poorer outcomes

Exa-cel shows complete success in early pediatric trials for sickle cell disease and beta-thalassemia

WHO Member States push forward toward a unified Pathogen Access and Benefit Sharing system

New Lancet series blends social science with medicine to tackle global health inequities

Genetic variant linked to higher heart failure risk in children with myocarditis

Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Bacterial enzyme linked to heart complications in pneumonia

Scientists uncover why SETX-deficient cancer cells rely on error-prone DNA repair

New drug combination shows promise for overcoming resistance in ovarian cancer

Common childhood virus linked to bladder cancer later in life

Wind-borne mosquitoes carry infectious pathogens for hundreds of miles

Retinal organoids provide a powerful tool to diagnose and study Leber congenital amaurosis

Poor kidney function associated with elevated Alzheimer’s markers in the blood

New rapid test distinguishes real HIV infections from vaccine-related false positives

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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