Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Study reveals link between circulating tumor cells and relapse in late-stage melanoma patients

A study revealing a connection between circulating tumor cells (CTCs) and relapse in stage IV melanoma patients points to liquid biopsy as a potential predictor of patients at high risk for disease progression. CTCs, tumor cells shed into the bloodstream or lymphatic system, can lead to additional tumor growth and/or metastasis to distant sites.

7 Nov 2017

Preclinical studies show effectiveness of targeted therapy for glioblastoma

The targeted therapy onalespib has shown effectiveness in preclinical studies of glioblastoma by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

2 Nov 2017

Cleveland Clinic researcher awarded $2.6 million grant to create innovative models of colorectal cancer

Cleveland Clinic researcher Emina Huang, M.D., a colorectal surgeon in the Digestive Disease and Surgery Institute and a staff member in the Lerner Research Institute's Department of Stem Cell Biology and Regenerative Medicine, has been awarded a collaborative five-year, $2.6 million grant from the National Cancer Institute to create innovative models of colorectal cancer that will enhance understanding of how the disease develops and spreads.

31 Oct 2017

Mechanical memory of cells could hold new clues to tumor invasion

In the body, cells move around to form organs during development; to heal wounds; and when they metastasize from cancerous tumors.

28 Oct 2017

New findings offer promising druggable target to root out metastatic pancreatic cancer

Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer's insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.

28 Oct 2017

Newly identified microRNA impedes malignancy of tumor cells and metastasis

Cancer cells can reactivate a cellular process that is an essential part of embryonic development. This allows them to leave the primary tumor, penetrate the surrounding tissue and form metastases in peripheral organs.

27 Oct 2017

Regional anesthesia for breast cancer surgery patients associated with better outcomes

Physicians believe that the use of regional anesthesia is associated with lower levels of inflammation and a better immune response in breast cancer surgery patients.

26 Oct 2017

Study elucidates how obesity makes breast cancer more aggressive

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technische Universität München, and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.

23 Oct 2017

Researchers reveal how certain nerves sustain prostate cancer growth

In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels to proliferate.

20 Oct 2017

Investigating new cancer therapy candidates with live-cell imaging

There are two main things that we've worked on in the lab as regards to drug studies. One is identifying new combinations of drugs, and working on why a combination of drugs should work better than each alone.

From Sartorius 16 Oct 2017

New study describes unique role of androgens in kidney cancer

A new study is believed to be the first to describe the unique role of androgens in kidney cancer, and it suggests that a new approach to treatment, targeting the androgen receptor (AR), is worth further investigation.

13 Oct 2017

Cholesterol byproduct acts on specific immune cells to facilitate breast cancer spread

High cholesterol levels have been associated with breast cancer spreading to other sites in the body, but doctors and researchers don't know the cause for the link.

12 Oct 2017

New computer program identifies different cell types based on gene expression patterns

"How many different cell types are there in a human body? And how do these differences develop? Nobody really knows," says Professor Stein Aerts from KU Leuven and VIB, Belgium. But thanks to a new method developed by his team, that may be about to change.

10 Oct 2017

University of Akron researcher awarded NSF grant to study bone remodeling

Osteoporosis is a disease categorized by brittle bones and increased risk of fracture. Individuals with osteoporosis, and diseases like it, have access to a number of treatments but no permanent solution.

9 Oct 2017

Genetic signature within prostate cancer cells can predict metastatic tumors

Many prostate cancers, which generally are diagnosed in older men, are "indolent," slow-growing tumors that aren't destined to be fatal. But some tumors are prone to becoming aggressive and spreading beyond the prostate, making them difficult to treat and life-threatening.

6 Oct 2017

FDA approves Verzenio for advanced metastatic breast cancer

The U.S. Food and Drug Administration (FDA) has approved a new drug Verzenio (abemaciclib) for the treatment of advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.

2 Oct 2017

First-ever treatment for Merkel cell carcinoma receives approval in Japan

Merck KGaA, Darmstadt, Germany, and Pfizer Inc. today announced that the Japanese Ministry of Health, Labor, and Welfare (MHLW) has approved BAVENCIO (avelumab, genetically recombinant Injection 200mg/mL for intravenous use) as the first and only treatment indicated for curatively unresectable Merkel cell carcinoma (MCC), a rare and aggressive cancer, in Japan.

27 Sep 2017