Proliferation News and Research

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Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable and favorable disease prognosis respectively.

28 Jun 2021

Understanding new resting phase of stem cells could help put glioma tumors to sleep

Christopher Plaisier, an assistant professor of biomedical engineering in the Ira A. Fulton Schools of Engineering at Arizona State University, and Samantha O'Connor, a biomedical engineering doctoral student in the Plaisier Lab, are leading research into a new stage of the stem cell life cycle that could be the key to unlocking new methods of brain cancer treatment.

25 Jun 2021

TET enzymes play key role in keeping immune cells on a healthy track

Researchers at La Jolla Institute for Immunology (LJI) have shed light on a process in immune cells that may explain why some people develop cardiovascular diseases.

25 Jun 2021

New 3Cs multiplex technique based on CRISPR-Cas technology helps study cancer mutations

Cancer and many other diseases are based on genetic defects. The body can often compensate for the defect of one gene; it is only the combination of several genetic errors that leads to the clinical picture.

25 Jun 2021

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.

25 Jun 2021

New risk score system to accurately predict leukemia relapse

Leukemia is a group of blood cancers that affects thousands of people worldwide. However, with advances in medicine, several different types of leukemia can be effectively treated with donor stem cells through allogenic stem cell transplantation (allo-SCT).

24 Jun 2021

Researchers uncover new function of regulator protein in multiple myeloma development

A specific regulatory protein significantly influences the development of tumor-inducing blood vessels in the bone marrow of blood cancer patients.

24 Jun 2021

Albumin supplementation improves human fertility, fights infection

A new University of California, Irvine-led study reveals albumin (Alb), among the most abundant proteins in the body, activates a proton channel (hHv1), also widespread in the body, giving sperm the ability to penetrate and fertilize an egg, and allowing white blood cells to secrete large amounts of inflammatory mediators to fight infection.

22 Jun 2021

CSHL researchers discover how pancreatic cancer cells develop resistance to drug treatments

Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. Cold Spring Harbor Laboratory Cancer Center Director David Tuveson and his team investigated the basis of "adaptive resistance" common to pancreatic cancer.

22 Jun 2021

Researchers decode the mechanisms of cell renewal process

The human intestine is made up of more than 40 square meters of tissue, with a multitude of folds on its internal surface that resemble valleys and mountain peaks in order to increase the absorption of nutrients.

22 Jun 2021

Researchers unravel cellular mechanisms driving the initiation of mammary gland development

Helsinki University research group used live tissue imaging for the first time to visualize the emergence of the mammary gland.

21 Jun 2021

Researchers uncover the role of macrophages in liver growth after massive resections

RUDN University doctors found out what role macrophages play in the recovery of the liver after the removal of its significant part. The results are published in the journal Biomedicine & Pharmacotherapy.

21 Jun 2021

New technique can measure metabolic process at the single-cell level

Understanding cellular metabolism - how a cell uses energy- could be key to treating a wide array of diseases, including vascular diseases and cancer.

18 Jun 2021

Which vitamins and minerals help with COVID?

A study published in the journal Inflammopharmacology reviewed recent data related to the role of vitamins and minerals in treating COVID-19 patients. The primary goal of the review is to highlight the possible therapeutic role of vitamins A, B, C, D, E and K, and micronutrients as immunity boosters in COVID-19 patients.

18 Jun 2021

The role of natural killer cells in fight against viral infections including SARS-CoV-2

In an effort to further understand the role of NK cells in combatting COVID-19, a group of researchers explored NK cells in acute viral infections, citing flavivirus and influenza virus infections as examples.

17 Jun 2021

Change in diet and circadian clock can impact healthy fat tissue, finds study

Changing your eating habits or altering your circadian clock can impact healthy fat tissue throughout your lifespan, according to a preclinical study published today in Nature by researchers with The University of Texas Health Science Center at Houston.

15 Jun 2021

New wound gap closure mechanism may offer faster, better healing after injury or surgery

The observation of a previously undetected biological mechanism for closing gaps in living tissue improves basic understanding of the wound-healing process and may one day inform strategies to speed healing after surgery, according to a team of Penn State and Singapore researchers.

14 Jun 2021

Hair follicle stem cells play an outsize role in healing skin blisters

A team of scientists has shown that the healing of skin blisters is driven by hair follicle stem cells, which delay their own development in the process.

14 Jun 2021

What makes the elderly more susceptible to SARS-CoV-2 infection?

Why is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease 2019), biased towards infecting the aged population? A recently published study by Italian scientists linked aging, DNA damage, telomere shortening, and increased levels of angiotensin-converting enzyme 2 (ACE2) to this relationship.

13 Jun 2021

Proliferation News and Research

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Understanding new resting phase of stem cells could help put glioma tumors to sleep

TET enzymes play key role in keeping immune cells on a healthy track

New 3Cs multiplex technique based on CRISPR-Cas technology helps study cancer mutations

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

New risk score system to accurately predict leukemia relapse

Researchers uncover new function of regulator protein in multiple myeloma development

Albumin supplementation improves human fertility, fights infection

CSHL researchers discover how pancreatic cancer cells develop resistance to drug treatments

Researchers decode the mechanisms of cell renewal process

Researchers unravel cellular mechanisms driving the initiation of mammary gland development

Researchers uncover the role of macrophages in liver growth after massive resections

New technique can measure metabolic process at the single-cell level

Which vitamins and minerals help with COVID?

The role of natural killer cells in fight against viral infections including SARS-CoV-2

Change in diet and circadian clock can impact healthy fat tissue, finds study

New wound gap closure mechanism may offer faster, better healing after injury or surgery

Hair follicle stem cells play an outsize role in healing skin blisters

What makes the elderly more susceptible to SARS-CoV-2 infection?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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