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Radiolabeled protein lights up tumor to reveal where cancer drugs are working

Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of a cancer remain unaffected.

28 Mar 2019

Study: Lack of physician guidance and fear of side effects are reasons for refusing statins

Despite national guidelines indicating that statins can lower risk of heart attack and stroke, many patients who could benefit do not take them.

28 Mar 2019

FDA approves new oral treatment for men with certain forms of hypogonadism

The U.S. Food and Drug Administration today approved Jatenzo (testosterone undecanoate), an oral testosterone capsule to treat men with certain forms of hypogonadism.

27 Mar 2019

Exercise helps prevent cartilage degradation caused by osteoarthritis, study shows

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London.

27 Mar 2019

C-Path and Japan's PMDA join forces on first-of-its-kind biomarker project

Critical Path Institute announced today that a formal consultation between its Predictive Safety Testing Consortium and Japan's Pharmaceuticals and Medical Devices Agency has resulted in an agreement on a first-of-its-kind approach to compare the levels of eight novel urinary kidney safety biomarkers in healthy Japanese volunteers to data collected on these same biomarkers in healthy Western volunteers in a bridging study.

27 Mar 2019

Study explores how a hallucinogenic drug impacts the brains of mice

While there is increasing interest in using hallucinogenic drugs to treat conditions like depression and post-traumatic stress disorder, scientists are just beginning to understand what these drugs actually do in the brain—and how they cause hallucinations.

27 Mar 2019

Probing Submicron Protein Aggregation using Asymmetrical Flow Field-Flow Fractionation, AF4, and Light Scattering

The most recent developments by Wyatt in their instrumentation and software have made the full potential of FFF accessible to a wider user base. In this interview, Kim R. Williams and Christoph Johann talk to News-Medical and Life Sciences about the technologies and their research.

From Waters | Wyatt Technology 27 Mar 2019

Study finds novel opportunity for treating subgroup of cancer patients with MSI-H tumors

Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife.

27 Mar 2019

Encapsulating human beta cells with immune-repelling protein restores glucose metabolism in diabetic mice

Encapsulating human stem-cell-derived beta cells in microcapsules made with a protein that repels key immune cells restored glucose metabolism in diabetic mice and protected the cells from immune system attack, preventing the buildup of inflammatory fibrotic tissue that has plagued previous trials of encapsulated beta cells.

27 Mar 2019

Contraceptive jewelry may be new approach to family planning for women

Family planning for women might one day be as simple as putting on an earring.

27 Mar 2019

Male contraceptive pill crosses the human clinical trial hurdle

Birth control pills have been around for the past six decades but have been for use of women only. A team of researchers this week have announced the success of the first male birth control pill that could safely prevent pregnancy.

27 Mar 2019

FDA approves new drug to treat adults with relapsing forms of MS

The U.S. Food and Drug Administration today approved Mayzent (siponimod) tablets to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

27 Mar 2019

Discovery could lead to new drugs for pain conditions

If a particular protein is missing during the fetal stage, no neurons develop that convey pain, temperature and itch, a study from Karolinska Institutet in Sweden published in the journal Cell Reports shows. The discovery can eventually lead to new drugs for pain conditions.

27 Mar 2019

New short-pulse ultrasound technique enhances drug delivery to brains of mice

Scientists currently use long-wave pulses of ultrasound to deliver drugs, which can cause side effects. These new findings from Imperial on shorter-wave pulses could have implications for how drugs are used to help patients of Alzheimer's and other neurological diseases.

26 Mar 2019

Impact of legalizing cannabis on the opioid crisis

Legislators believe that the passage of cannabis access laws will play a significant role in addressing the ongoing opioid crisis.

26 Mar 2019

Symptomatic pharmacotherapy of elderly people should be regularly monitored

The prevalence of using antidepressants and proton pump inhibitors increases after the diagnosis of Alzheimer’s disease, according to a doctoral dissertation from the University of Eastern Finland.

26 Mar 2019

Enamine and Lundbeck announce expansion of drug discovery collaboration

Enamine and H. Lundbeck today announced the expansion of their research collaboration.

From Enamine Ltd 26 Mar 2019

LNC Therapeutics announces grant of Cornell University patent relating to christensenella bacteria

LNC Therapeutics, a French biotech company specializing in gut microbiome-based drug discovery, announced today the grant of the Cornell University (Ithaca, New-York, USA) patent relating to christensenella bacteria.

26 Mar 2019

Improved TB Diagnostic Assay for Better Multiplexing from Bruker

In time for the World Tuberculosis (TB) Day 2019 on Sunday, March 24th, Bruker today announced the launch of an important further innovation in the field of tuberculosis diagnostics.

From Bruker BioSpin Group 26 Mar 2019

Causes of diabetes decline or disappear when ‘zombie cells’ are removed, shows study

Mayo Clinic researchers and their collaborators have shown that when senescent cells -- also known as "zombie cells" -- are removed from fat tissue in obese mice, severity of diabetes and a range of its causes or consequences decline or disappear. The findings appear in Aging Cell.

26 Mar 2019