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Male and female rats show different patterns of kidney gene expression throughout their lives

Male and female rats show different patterns of kidney gene expression throughout their lives, a study in the open access journal Biology of Sex Differences reveals. The finding could help explain some of the gender differences observed in human renal disease, and lead to improved biomarkers of kidney function.

31 Jul 2013

Perfluoroalkyl substances are crossing blood brain barrier of polar bears

PerFluoroAlkyl Substances (PFASs) and precursor compounds have been used in a wide variety of commercial and industrial products over the past six decades. Applications include water and oil repellent coatings, e.g. for textiles, paper products, carpets and food packaging, pharmaceuticals and surfactants in cleaning products and fire-fighting foams.

25 Jul 2013

Melatonin pre-treatment greatly increases cell survival, say researchers

When melatonin, a hormone secreted by the pineal gland, was used as a pre-treatment for mesenchymal stem cells prior to their transplantation into the brains of laboratory animals to repair damage from stroke, researchers in China found that the stem cells survived longer after transplantation. Previous studies had shown that 80 percent of transplanted MSCs died within 72 hours of transplantation.

23 Jul 2013

Jersey Shore to present free educational conference focusing on thyroid cancer patients, survivors

On Friday, August 2, 2013, Jersey Shore, in partnership with Meridian Cancer Care and the Light of Life Foundation, will present a free educational conference featuring Meridian Health specialists.

22 Jul 2013

Metabolomics tools predict who can benefit from treatment with certain antidepressants

Duke Medicine researchers have identified biochemical changes in people taking antidepressants - but only in those whose depression improves. These changes occur in a neurotransmitter pathway that is connected to the pineal gland, the part of the endocrine system that controls the sleep cycle, suggesting an added link between sleep, depression and treatment outcomes.

19 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

The study is reported on July 17, 2013, in an advance online edition of the journal Nature, alongside a British laboratory's structural study of another member of the same class of receptors-known as "class B" G protein-coupled receptors (GPCRs).

18 Jul 2013

Seafood provides essential nutrients but consumers still keep watchful eye on safety

Seafood continues to be a proven strong nutrient-rich food providing essential vitamins, minerals and omega-3 fatty acids, but consumers and some toxicologists still keep a watchful eye on safety, according to a July 16 panel discussion at the 2013 Institute of Food Technologists (IFT) Annual Meeting & Food Expo- held at McCormick Place.

18 Jul 2013

Vitamin D-deficient older individuals are more likely to struggle with everyday tasks

Chevy Chase, MD-Vitamin D-deficient older individuals are more likely to struggle with everyday tasks such as dressing or climbing stairs, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

18 Jul 2013

Exposure to PFC may increase risk of mild hypothyroidism in women

Exposure to perfluorinated chemicals is linked to changes in thyroid function and may raise the risk of mild hypothyroidism in women, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

18 Jul 2013

Modified forms of bisphenol A found to alter hormone signaling in new, disturbing ways

For years, scientists have been worried about bisphenol A. The chemical is known as an "endocrine disruptor," a substance that interferes with the body's hormone signaling system, and it's found in everything from plastic drink bottles to the linings of food and drink cans to the thermal paper used for cash register receipts - not to mention the urine of 92.6 percent of Americans over the age of six.

18 Jul 2013

Study shows flavonoid-based nutritional supplements can affect endocrine system

Plant-based diets are healthy. Plants are high in flavonoids. So flavonoids are healthy. At least that's the reasoning of many manufacturers of flavonoid-based nutritional supplements.

16 Jul 2013

Adverse fetal growth, exposure to maternal smoking correlated with lower measures of sperm quality

Studies over the past 20 years have suggested (though not unequivocally confirmed) that semen quality is in decline, reflected most evidently in falling sperm counts and reduced sperm motility.

8 Jul 2013

Risk of implantation failure, lower yield of oocytes linked to higher levels of urinary phthalates

Phthalates are among a group of industrial chemicals shown in some studies to have adverse effects on reproductive health and development, particularly in the male. As such, they have been collectively defined as "endocrine disruptors", and proposed as one of several possible environmental exposures responsible for a decline in fertility.

8 Jul 2013

Prosigna Breast Cancer Prognostic Gene Signature Assay study published in JCO

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced that the TransATAC clinical validation study for its Prosigna Breast Cancer Prognostic Gene Signature Assay, which is based on the PAM50 gene signature, was published in the Journal of Clinical Oncology.

From NanoString Technologies 2 Jul 2013

Research shows food contaminants are responsible for metabolic changes in obese mice

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

28 Jun 2013

Use of antibacterial soaps containing chemical triclocarban may harm nursing babies

A mother's prolonged use of antibacterial soaps containing the chemical triclocarban may harm nursing babies, according to a recent study from the University of Tennessee, Knoxville.

28 Jun 2013

Mary Ann Liebert, ATA announce major plans for expansion of Thyroid journal

Mary Ann Liebert, Inc., publishers and the American Thyroid Association announced major plans for the expansion of the flagship journal Thyroid to include two additional important components to better serve the thyroid community and to foster optimal patient care.

28 Jun 2013

Sentinel lymph node biopsy for early breast cancer: an interview with Prof. Gordon Wishart, Anglia Ruskin University

Our current method, which is recommended by the Association of Breast Surgeons in the UK, involves the use of injections of blue dye and radioisotope to identify the first node(s) under the arm (axilla) called the sentinel nodes.

25 Jun 2013

Study finds that triple therapy corrects two core defects in type 2 diabetes

Patients with type 2 diabetes fare significantly better if they are started on three medications at the time of diagnosis than if they are prescribed a single drug and have other therapies added later, a San Antonio researcher said June 22 at the 73rd Scientific Sessions of the American Diabetes Association in Chicago.

25 Jun 2013

Endocrine News and Research

Male and female rats show different patterns of kidney gene expression throughout their lives

Perfluoroalkyl substances are crossing blood brain barrier of polar bears

Melatonin pre-treatment greatly increases cell survival, say researchers

Jersey Shore to present free educational conference focusing on thyroid cancer patients, survivors

Metabolomics tools predict who can benefit from treatment with certain antidepressants

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

Seafood provides essential nutrients but consumers still keep watchful eye on safety

Vitamin D-deficient older individuals are more likely to struggle with everyday tasks

Exposure to PFC may increase risk of mild hypothyroidism in women

Modified forms of bisphenol A found to alter hormone signaling in new, disturbing ways

Study shows flavonoid-based nutritional supplements can affect endocrine system

Adverse fetal growth, exposure to maternal smoking correlated with lower measures of sperm quality

Risk of implantation failure, lower yield of oocytes linked to higher levels of urinary phthalates

Prosigna Breast Cancer Prognostic Gene Signature Assay study published in JCO

Research shows food contaminants are responsible for metabolic changes in obese mice

Use of antibacterial soaps containing chemical triclocarban may harm nursing babies

Mary Ann Liebert, ATA announce major plans for expansion of Thyroid journal

Sentinel lymph node biopsy for early breast cancer: an interview with Prof. Gordon Wishart, Anglia Ruskin University

Study finds that triple therapy corrects two core defects in type 2 diabetes

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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