Preclinical News and Research

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Novel PET tracer accurately detects common cancer mutation for tailored treatment

A novel PET imaging tracer has been proven to safely and effectively detect a common cancer gene mutation that is an important molecular marker for tumor-targeted therapy.

2 Jan 2024

Brain receptor discovery opens door to new therapies for addiction and mental health

Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic medication asenapine, a possible therapeutic target for substance use and neuropsychiatric disorders.

2 Jan 2024

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

28 Dec 2023

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Very early in the COVID-19 pandemic clinical trials in patients hospitalized with COVID-19 confirmed that corticosteroids like dexamethasone reduced mortality, but they were harmful when applied at the first COVID-19 symptoms, due to the weakening of innate antiviral immunity, leading to delayed viral clearance and adverse outcomes in severe viral pneumonias.

28 Dec 2023

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Monkey stem cells made easy: New method unveils xeno-free, efficient culture system

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

22 Dec 2023

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer's disease.

20 Dec 2023

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

Researchers identified 5-hydroxytryptamine 2A (5-HT2A) receptor (5-HT2AR) signaling pathways associated with psychedelic potential.

19 Dec 2023

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Amidst a backdrop of industry-wide hurdles like inflation, talent scarcities, and stringent regulatory landscapes, Nona Biosciences is showing great promise as an emerging global leader in biotechnology.

From Nona BioSciences 19 Dec 2023

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models, they tested the effectiveness of an antibody to human signal regulatory protein alpha (SIRPα) for cancer immunotherapy.

19 Dec 2023

Study reveals altered time perception in early Alzheimer's stages, offering potential early diagnostic marker

Study investigates time perception in Alzheimer's disease and its preclinical stage, subjective cognitive decline (SCD), revealing specific alterations in temporal processing that could be early markers of cognitive decline.

18 Dec 2023

€7.4M EU grant boosts development of vaccines against Marburg viruses

International research consortium receives highly endowed Horizon Europe funding for the development of vaccines against Marburg viruses.

18 Dec 2023

Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine.

18 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

Novel drug combinations could protect snakebite victims from devastating injuries

New drug combinations could protect snakebite victims from the devastating, life-changing injuries caused by toxic venom, promising new research led by Liverpool School of Tropical Medicine suggests.

14 Dec 2023

Researchers develop humanized mouse model for macrophage-targeted cancer immunotherapy

Mice with human immune cells are a new way of testing anti-cancer drugs targeting the immune system in pre-clinical studies.

14 Dec 2023

Simple trick supercharges T cells to fight stubborn solid tumors

Wistar researchers successfully tested a simple intervention that could unlock greater anti-tumor power in therapies that use T cells - an approach known as "cell-based therapy," which uses specially designed T cells to fight cancer.

13 Dec 2023

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

13 Dec 2023

UK Aid awards funding to Oxford Vaccine Group for research into prevention of five epidemic threats

Oxford Vaccine Group (OVG), which led the rapid clinical development of the Oxford vaccine in COVID-19 in the pandemic, has been awarded a total of £7,788,783 by UK Aid for research into the prevention of five dangerous diseases with epidemic or pandemic potential.

13 Dec 2023

Preclinical News and Research

Novel PET tracer accurately detects common cancer mutation for tailored treatment

Brain receptor discovery opens door to new therapies for addiction and mental health

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Monkey stem cells made easy: New method unveils xeno-free, efficient culture system

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

Scientists design non-hallucinogenic psychedelic treatments potentially accelerating research on mental health benefits

Bridging ideas to IND: Nona Biosciences' year of impact in biotechnology

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Study reveals altered time perception in early Alzheimer's stages, offering potential early diagnostic marker

€7.4M EU grant boosts development of vaccines against Marburg viruses

Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors

Researchers unveil new way to sensitize resistant tumors to treatment

Novel drug combinations could protect snakebite victims from devastating injuries

Researchers develop humanized mouse model for macrophage-targeted cancer immunotherapy

Simple trick supercharges T cells to fight stubborn solid tumors

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

UK Aid awards funding to Oxford Vaccine Group for research into prevention of five epidemic threats

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