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High-quality human clinical trials needed to determine the benefits of CBD for heart disease patients

As cannabidiol (CBD) use rises, high quality randomized clinical trials are needed to determine if anti-inflammatory benefits of CBD for heart disease seen in preclinical data will work in a real-world setting, according to research presented at ACC Latin America 2022 Together with CardioAcademic.

5 Sep 2022

Targeting Gαq/11 may be an efficient therapeutic strategy against uveal melanoma

Announcing a new article publication from Acta Pharmaceutica Sinica B. Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies.

5 Sep 2022

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Synexa is an industry-leading biomarker and large molecule bio analytic research service provider. In this interview, NewsMedical speaks with Natalie Strickland, a principal scientist at Synexa, about alternative approaches to flow cytometry.

From Synexa Life Sciences 5 Sep 2022

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

A new study determines the antiviral efficacy of favipiravir against ZIKV and SARS-CoV-2 infections.

4 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

The current study focused on the ability of this nmAb to neutralize Delta, Omicron, and other VOCs, as well as its efficacy when given by the intranasal route in an animal model.

1 Sep 2022

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

α-synuclein is a neuronal protein involved in functions like vesicle trafficking and neurotransmitter release. It is typically found in abundance in a healthy brain.

30 Aug 2022

Study finds strong evidence for the ability of SARS-CoV-2 to infect human sperm in vitro

Researchers explored the molecular and cellular mechanisms of SARS-CoV-2 infection.

30 Aug 2022

A leather-based in vitro model for determining the effect of cosmetics on skin microbes

A recent study discusses the development of a leather-based in vitro model due to its close resemblance to human skin.

28 Aug 2022

Chinese researchers identify a new molecular mechanism of NASH pathogenesis

Nonalcoholic steatohepatitis (NASH), characterized by liver steatosis, inflammation and injury, has emerged as one of major causes for end-stage liver disease like hepatocellular carcinoma. However, what drives its progression?

25 Aug 2022

Targeting Na+/K+ ATPase alpha 1 proteins could help identify novel therapies for blood clots, thrombosis

Targeting Na+/K+ ATPase alpha 1 (ATP1A1) subunit proteins could help identify novel therapies for addressing blood clots and thrombosis, according to a new study by Marshall University researchers.

24 Aug 2022

The role of SARS-CoV-2-specific T cells induced by infection, vaccination, or their combination in disease protection

Researchers evaluated how SARS-CoV-2-specific-T lymphocytes induced by infection, vaccination, or both conferred protection against severe COVID-19.

24 Aug 2022

Biological effects of nanoplastics in paints

A recent study analyzed paint composition and its biological properties, as paints release polymers and particles into the environment.

24 Aug 2022

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

A new study examines the potential benefit of the glucokinase activator molecule AZD1656 in the ARCADIA trial.

23 Aug 2022

DNA origami as an alternative platform to display the RBD of SARS-CoV-2

Researchers demonstrated DNA origami as a potential platform to display the SARS-CoV-2 receptor-binding domain.

23 Aug 2022

What risk factors are associated with post-acute sequelae of SARS-CoV-2?

Researchers explored the risk factors correlated with post-acute sequelae of SARS-CoV-2.

23 Aug 2022

Flipping the switch on retrons to combat antimicrobial resistance

In this interview, we speak to Dr. Jacob Bobonis about his new discovery regarding retrons and how they could be used to tackle antimicrobial resistance.

23 Aug 2022

Single dose of aged mouse blood in young mice causes senescence

Scientists performed heterochronic blood exchange in male mice and observe that aged mouse blood triggered cell and tissue senescence in younger mice.

18 Aug 2022

Circuits of touch and sight are intermingled in the embryo, study shows

In embryonic stages, tactile stimuli simultaneously activate tactile and visual neural pathways. Shortly after birth, both pathways reorganize to allow separate processing of touch and vision.

18 Aug 2022

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

Researchers investigated the role of the CD98 glycoprotein in inducing an inflammatory response to SARS-CoV-2 in patients of progressive fibrosis interstitial lung diseases, including the archetypal PFILD, idiopathic pulmonary fibrosis.

18 Aug 2022

in vivo News and Research

High-quality human clinical trials needed to determine the benefits of CBD for heart disease patients

Targeting Gαq/11 may be an efficient therapeutic strategy against uveal melanoma

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

Study finds strong evidence for the ability of SARS-CoV-2 to infect human sperm in vitro

A leather-based in vitro model for determining the effect of cosmetics on skin microbes

Chinese researchers identify a new molecular mechanism of NASH pathogenesis

Targeting Na+/K+ ATPase alpha 1 proteins could help identify novel therapies for blood clots, thrombosis

The role of SARS-CoV-2-specific T cells induced by infection, vaccination, or their combination in disease protection

Biological effects of nanoplastics in paints

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

DNA origami as an alternative platform to display the RBD of SARS-CoV-2

What risk factors are associated with post-acute sequelae of SARS-CoV-2?

Flipping the switch on retrons to combat antimicrobial resistance

Single dose of aged mouse blood in young mice causes senescence

Circuits of touch and sight are intermingled in the embryo, study shows

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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