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“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Richard Eglen discusses the use of organoids in drug discovery, including the screening of candidate compounds for efficacy, toxicity, and pharmacokinetics.

From Corning Life Sciences 13 Mar 2019

Access to real-time genotype data influences prescriber behavior after PCI

Today, in a late-breaking featured clinical research session at the American College of Cardiology Scientific Sessions 2018, researchers from Penn Medicine present first-of-its-kind data on the impact of real-time CYP2C19 genotype results when prescribing antiplatelet drugs in the clinic.

13 Mar 2019

Scientists find highly promising therapeutic target for leukemia

Cancer cells consume sugar at a higher rate than healthy cells, but they're also hungry for amino acids, the building blocks of proteins and other biomolecules.

13 Mar 2019

Study unravels how cancer medication works in brains of Parkinson's patients

Laboratory analysis from the first arm of a phase II clinical trial testing the use of nilotinib in patients with Parkinson's disease demonstrates precisely how the agent increases levels of dopamine in the brains of study participants, says a research team at Georgetown University Medical Center. Symptoms of Parkinson's, such as motor dysfunction, are a result of a dopamine loss.

13 Mar 2019

Study explores whether Nordic countries could head towards opioid crisis like the U.S.

Addiction to prescription opioids has reached a crisis level in the United States. Now the drug is causing concern across the Atlantic. Researchers from Denmark, Norway and Sweden urge caution after discovering that prescriptions for the pain medication oxycodone have significantly increased during the last decade.

13 Mar 2019

Researchers develop new molecule that halts progression of heart failure

A group of researchers based in Brazil and the United States have developed a molecule that halts the progression of heart failure and improves the heart's capacity to pump blood.

13 Mar 2019

CT scan of the lumbar spine prior to surgery reveals undiagnosed osteoporosis in many patients

For patients contemplating spinal fusion surgery to alleviate pain, bone health is an important consideration. If a patient is found to have low bone density prior to surgery, it could affect the treatment plan before, during and after the procedure.

13 Mar 2019

New findings about efficient use of resources after orthopedic surgeries

Patients who live close to the hospital at which they have undergone total hip or total knee replacement are much more likely to visit the emergency room for follow-up care of pain, inflammation and other complaints than those who live farther away, according to a new study by researchers at Hospital for Special Surgery in New York City and The Ochsner Clinic in New Orleans.

13 Mar 2019

Novel biosensor can isolate and target leukemic stem cells

All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most malignant of all leukemic cells. Understanding how leukemic stem cells are regulated has become an important area of cancer research.

12 Mar 2019

New sensing tool could aid in early detection of Dengue virus

Dr Paulo Rocha from the University of Bath's Department of Electronic & Electrical Engineering is developing a low-cost integrative sensing tool for early detection of Dengue virus, using a novel platform containing electrical sensors to investigate the behavior of human cells infected with Dengue virus.

12 Mar 2019

Killer flu pandemic is inevitable and world is not prepared, says WHO

The World Health Organisation has said that the world is not prepared for a global flu pandemic and that resources are inadequate.

12 Mar 2019

UVA researchers discover potential contributor to age-related hearing loss

Researchers at the University of Virginia School of Medicine have discovered a new potential contributor to age-related hearing loss, a finding that could eventually help doctors identify people at risk.

12 Mar 2019

Forty percent of parents are not co-sleeping safely with their babies

According to a survey of 8551 people, 40 percent of parents are not following safe co-sleeping practices with their babies, and this is significantly increasing the risk of Sudden Infant Death Syndrome (SIDS).

12 Mar 2019

Experts issue new guidelines for use of genetic testing in psychiatric care

An expert committee of psychiatrists and geneticists has issued revised guidelines for the use of genetic testing in psychiatric care.

12 Mar 2019

Study provides new understanding about blood pressure control in older adults

Until recently, physicians had generally assumed that older adults benefit from keeping their blood pressure below 140/90 mmHg. However, researchers from Charité - Universitätsmedizin Berlin have now found that this assumption does not apply to all patients with high blood pressure.

12 Mar 2019