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Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair achieved significant tumor regression in mouse models of small cell lung cancer, suggesting a promising new approach for treating patients with this aggressive cancer.

18 Feb 2019

Activating gene that helps excite neurons reverses depression in male mice

Directly activating a gene important to exciting our excitatory neurons and associated with major depression may help turn around classic symptoms like social isolation and loss of interest, at least for males, scientists report.

18 Feb 2019

Drug combinations could become first-line treatment for metastatic kidney cancer

A combination of two drugs - one of them an immunotherapy agent - could become a new standard, first-line treatment for patients with metastatic kidney cancer, says an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

18 Feb 2019

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Columbia researchers have learned why some glioblastomas--the most common type of brain cancer--respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.

17 Feb 2019

Patented IU discovery to treat ARDS has been optioned to Theratome Bio

A patented Indiana University School of Medicine discovery that uses proteins, lipids and nucleic acids secreted by adult stem cells to treat Acute Respiratory Distress Syndrome, or ARDS, has been optioned to Theratome Bio, an Indianapolis-based life sciences company.

17 Feb 2019

H-RT should be the standard of care for men with low risk prostate cancer, study shows

Results from the NRG Oncology clinical study NRG-RTOG 0415 determined that a hypofractionated radiotherapy schedule, a treatment schedule that delivers a total dose of radiotherapy over a shorter period of time, is not worse than the conventional radiotherapy schedule in terms of bowel, bladder, sexual, and general quality of life as well as anxiety and depression for men with low risk prostate cancer.

15 Feb 2019

New technique using patients' own modified cells could help treat Crohn's disease

A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.

15 Feb 2019

Castration-resistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

Some patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco.

15 Feb 2019

Therapeutic endoscopy has an expanding role in the treatment of IBD

According to a new statement from a panel of national and international experts in gastroenterology, inflammatory bowel disease (IBD) and other areas, interventional (or therapeutic) IBD endoscopy has an expanding role in the treatment of disease and of adverse events from surgery.

15 Feb 2019

Newly developed stem cell technologies show promise for treating PD patients

Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

15 Feb 2019

Large-scale clinical trial begins to study liver transplantation between people with HIV

The first large-scale clinical trial to study liver transplantation between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Liver Study will determine the safety of this practice by evaluating liver recipients for potential transplant-related and HIV-related complications following surgery.

15 Feb 2019

Moffitt researchers shed light on how CAR T cells function mechanistically

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells.

15 Feb 2019

FDA authorizes new interoperable insulin pump for children, adults with diabetes

The U.S. Food and Drug Administration today permitted marketing of the Tandem Diabetes Care t:Slim X2 insulin pump with interoperable technology (interoperable t:Slim X2) for delivering insulin under the skin for children and adults with diabetes.

15 Feb 2019

Bio-Rad launches new digital PCR system and kit for monitoring treatment response in CML patients

Bio-Rad Laboratories, Inc., a global leader of life science research and clinical diagnostic products, today announced that its QXDx AutoDG ddPCR System, which uses Bio-Rad's Droplet Digital PCR technology, and the QXDx BCR-ABL %IS Kit are the industry's first digital PCR products to receive U.S. Food and Drug Administration clearance.

15 Feb 2019

Depression prevention for pregnant women and new mothers – new recommendations

At present all new mothers are screened for symptoms of depression and help is provided to those who need care. The U.S. Preventive Services Task Force now has urged doctors to screen pregnant women for risks of depression and provide adequate counselling and support to prevent the onset of depression after delivery. The report was published in the Journal of the American Medical Association this week.

14 Feb 2019

Human cells can change their original function to battle against diabetes

For the first time, researchers have shown that ordinary human cells can change their original function. This may give new hope for diabetes patients.

14 Feb 2019

Blood-based liquid biopsies can accurately track cancer treatment responses

Results of two clinical studies have added to evidence that blood-based liquid biopsies can accurately track lung cancer treatment responses by measuring circulating tumor DNA (ctDNA) during immunotherapy and related treatments.

14 Feb 2019

New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis

A new reversible, drug-free antiplatelet therapy could reduce the risk of blood clots and potentially prevent cancer metastasis, according to a study published today in Science Translational Medicine.

14 Feb 2019

Mount Sinai awarded $12.5 million NIH grant for research program in aging biology

Researchers from the Icahn School of Medicine at Mount Sinai have been awarded a $12.5 million grant from the National Institute on Aging, part of the National Institutes of Health, for a five-year program called the U19 that consists of four multidisciplinary projects in aging biology.

14 Feb 2019

Discovery of a 'master switch' within the immune system

Researchers Professor Graham Lord, from The University of Manchester and colleagues have found that a specific part of the immune system could have the tools that may help in the therapy of some major diseases such as diabetes, cancer, multiple sclerosis, Crohn’s disease and other autoimmune diseases.

14 Feb 2019

Therapy News and Research

Combination of PARP inhibitor and immunotherapy results in tumor regression in SCLC mouse models

Activating gene that helps excite neurons reverses depression in male mice

Drug combinations could become first-line treatment for metastatic kidney cancer

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Patented IU discovery to treat ARDS has been optioned to Theratome Bio

H-RT should be the standard of care for men with low risk prostate cancer, study shows

New technique using patients' own modified cells could help treat Crohn's disease

Castration-resistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

Therapeutic endoscopy has an expanding role in the treatment of IBD

Newly developed stem cell technologies show promise for treating PD patients

Large-scale clinical trial begins to study liver transplantation between people with HIV

Moffitt researchers shed light on how CAR T cells function mechanistically

FDA authorizes new interoperable insulin pump for children, adults with diabetes

Bio-Rad launches new digital PCR system and kit for monitoring treatment response in CML patients

Depression prevention for pregnant women and new mothers – new recommendations

Human cells can change their original function to battle against diabetes

Blood-based liquid biopsies can accurately track cancer treatment responses

New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis

Mount Sinai awarded $12.5 million NIH grant for research program in aging biology

Discovery of a 'master switch' within the immune system

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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