Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

Study shows ABL kinases have enhanced expression and activity in CML

Chronic Myelogenous Leukemia (CML) is a cancer of the white blood cells that is most commonly found in adults and in the elderly. Its incidence has been estimated to be 1 to 2 in 100,000 people. CML was the first cancer to be associated with a genetic abnormality, known as the Philadelphia Chromosome, which 95% of all CML patients carry in their cells.

28 Aug 2013

Study: Apoptosis triggers alternate replication pathway in HHV

Washington, DC-Researchers from Children's National Medical Center have found that an alternate, "escape" replication process triggered by apoptosis-the process of cell death or "cell suicide"-appears to be common in human herpesviruses (HHV).

28 Aug 2013

Bioactive compounds in coffee may prevent prostate cancer recurrence, delay progression

Coffee consumption is associated with a lower risk of prostate cancer recurrence and progression, according to a new study by Fred Hutchinson Cancer Research Center scientists that is online ahead of print in Cancer Causes & Control.

27 Aug 2013

BES procedure may prevent cell apoptosis in stem cell-based transplantation therapy

Researchers at the Beihang University School of Biological Science and Medical Engineering, led by Dr. Yubo Fan, have discovered that Biphasic Electrical stimulation (BES), a non-chemical procedure, may be used as a strategy for preventing cell apoptosis in stem cell-based transplantation therapy.

26 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

Chinese herbal medicine JSK protects against injury caused by damage to spinal cord blood vessels

A new study published in Restorative Neurology and Neuroscience demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control rats.

20 Aug 2013

GHI research aims to target breast cancer stem-like cells using immunotherapy

New hope is on its way for the fight against breast cancer as Griffith Health Institute research aims to target the disease with immune-based therapies.

16 Aug 2013

Study: Cell cycle-related genes play important role in formation of neural tube defects

In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube.

16 Aug 2013

Flavonoids in celery, artichokes induce apoptosis in human pancreatic cancer cells

Celery, artichokes, and herbs, especially Mexican oregano, all contain apigenin and luteolin, flavonoids that kill human pancreatic cancer cells in the lab by inhibiting an important enzyme, according to two new University of Illinois studies.

16 Aug 2013

Neural stem cells transplantation in tumor-bearing rats can hinder tumor cell growth

Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and prolife-ration; however, the mechanism remains unclear.

14 Aug 2013

X-linked methyl-CpG protein may be potential target for treatment of Parkinson's

X-linked methyl-CpG binding protein 2 plays important role in the regulation of neuronal development, proliferation and maturation, and synaptic regeneration and apoptosis.

13 Aug 2013

OGF-OGFr axis can be modulated in human triple-negative breast cancer cells to inhibit proliferation

Researchers at The Pennsylvania State University College of Medicine, led by Dr. Ian S. Zagon, have discovered that a novel biological pathway, the OGF-OGFr axis, can be modulated in human triple-negative breast cancer cells to inhibit proliferation. According to BreastCancer.org 1 in 8 women in the U.S. will develop invasive breast cancer and more than 39,000 deaths occur annually.

12 Aug 2013

L-3-n-butylphthalide is potentially beneficial drug for treatment of vascular dementia

3-N-butylphthalide, a green botanical medicine, is a successfully synthesized and stable chemical drug used for the treatment of ischemic stroke that has independent intellectual property rights in China.

12 Aug 2013

Sericin can decrease blood glucose levels and alleviate diabetic hippocampal damage

Preliminary studies by Dr. Zhihong Chen and colleagues from Chengde Medical College have shown that sericin might improve aberrant Akt signaling, decrease heme oxygenase-1 expression in the hippocampus and cerebral cortex, and reduce the apoptosis of hippocampal neurons in diabetic rats, thus protecting the nervous system.

9 Aug 2013

Research suggests blocking DNA repair complex helps fight therapy-resistant leukemia

New research posted online by the Nature journal Leukemia suggests blocking part of a DNA repair complex that helps some types of leukemia resist treatment can increase the effectiveness of chemotherapy and enhance survival.

9 Aug 2013

Brain tumor cells in arrested development contribute to cell variety that protects cancer

A program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor, scientists at The University of Texas MD Anderson Cancer Center report this week in the Early Edition of the Proceedings of the National Academy of Sciences.

8 Aug 2013

New studies in mice support toxic role of aluminum in neurodegenerative conditions

Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer's disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum's neurotoxic effects.

6 Aug 2013

Study observes that long-term use of antihypertensive drugs associated with breast cancer risk

Older women who take certain types of medication to combat high blood pressure may be putting themselves at greater risk for developing breast cancer, according to a new study by a team of Fred Hutchinson Cancer Research Center scientists led by Christopher Li, M.D., Ph.D.

6 Aug 2013

BioLineRx reports positive results from pre-clinical trials with RHB-104 for treatment of thrombocytopenia

BioLineRx, a biopharmaceutical development company, announced today that BL-8040 has been shown in pre-clinical trials to be effective for the treatment of thrombocytopenia, or reduced platelet production.

5 Aug 2013

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

New Studies in Mice Support Toxic Role of Aluminum in Neurodegenerative Conditions, According to Report in Restorative Neurology and Neuroscience

3 Aug 2013

Apoptosis News and Research

Study shows ABL kinases have enhanced expression and activity in CML

Study: Apoptosis triggers alternate replication pathway in HHV

Bioactive compounds in coffee may prevent prostate cancer recurrence, delay progression

BES procedure may prevent cell apoptosis in stem cell-based transplantation therapy

Medical investigators discover new aspect of gene-splicing process that produces mRNA

Chinese herbal medicine JSK protects against injury caused by damage to spinal cord blood vessels

GHI research aims to target breast cancer stem-like cells using immunotherapy

Study: Cell cycle-related genes play important role in formation of neural tube defects

Flavonoids in celery, artichokes induce apoptosis in human pancreatic cancer cells

Neural stem cells transplantation in tumor-bearing rats can hinder tumor cell growth

X-linked methyl-CpG protein may be potential target for treatment of Parkinson's

OGF-OGFr axis can be modulated in human triple-negative breast cancer cells to inhibit proliferation

L-3-n-butylphthalide is potentially beneficial drug for treatment of vascular dementia

Sericin can decrease blood glucose levels and alleviate diabetic hippocampal damage

Research suggests blocking DNA repair complex helps fight therapy-resistant leukemia

Brain tumor cells in arrested development contribute to cell variety that protects cancer

New studies in mice support toxic role of aluminum in neurodegenerative conditions

Study observes that long-term use of antihypertensive drugs associated with breast cancer risk

BioLineRx reports positive results from pre-clinical trials with RHB-104 for treatment of thrombocytopenia

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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