Leukocyte News and Research

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ISU receives U.S. patent for phytol-derived adjuvant

While conducting research on cancer, Swapan Ghosh and a team of graduate and doctoral students discovered a phytol-derived adjuvant. That adjuvant formula just became U.S. Patent No. 8,088,395.

13 Jan 2012

Study shows how Notch gene and PRC2 protein complex work together to cause T-ALL

A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) protein complex, work together to cause T- cell acute lymphoblastic leukemia.

13 Jan 2012

First details of genetic alterations that fuel early T-cell precursor ALL

Researchers have discovered that a subtype of leukemia characterized by a poor prognosis is fueled by mutations in pathways distinctly different from a seemingly similar leukemia associated with a much better outcome. The findings from the St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (PCGP) highlight a possible new strategy for treating patients with this more aggressive cancer.

12 Jan 2012

Findings on cell working could lead to test and therapy for kidney failure caused by E. coli

New findings by St. Michael's researchers about the way cells work could lead to a test and therapy for kidney failure caused by E. coli

11 Jan 2012

Infectious disease-fighting drugs could be designed to block pathogen's entry into cells

New research shows that infectious disease-fighting drugs could be designed to block a pathogen's entry into cells rather than to kill the bug itself.

11 Jan 2012

MAL3-101 appears to have potent anti-tumor effects on multiple myeloma

A new study from SUNY Downstate Medical Center in Brooklyn, New York, shows that MAL3-101, a recently developed inhibitor of the heat shock protein 70 (Hsp70), appears to have potent anti-tumor effects on multiple myeloma, a bone marrow cancer.

10 Jan 2012

RNF123 gene may play a role in major depression

Psychiatric disorders can be described on many levels, the most traditional of which are subjective descriptions of the experience of being depressed and the use of rating scales that quantify depressive symptoms. Over the past two decades, research has developed other strategies for describing the biological underpinnings of depression, including volumetric brain measurements using magnetic resonance imaging (MRI) and the patterns of gene expression in white blood cells.

4 Jan 2012

Woman's ovarian cycle plays an important role in her susceptibility to infection

A new research report in the Journal of Leukocyte Biology suggests that a woman's ovarian cycle plays an important role in her susceptibility to infection.

4 Jan 2012

CEL-SCI to expand Multikine Phase III trial in head and neck cancer

CEL-SCI Corporation is in the process of expanding its Phase III clinical trial of the investigational therapy Multikine (Leukocyte Interleukin, Injection) to 4 additional European countries - Spain, Czech Republic, Slovakia and Croatia.

27 Dec 2011

CEL-SCI reports net loss of $26.8M for fiscal year ended September 30, 2011

CEL-SCI Corporation reported financial results today for the fiscal year ended September 30, 2011.

26 Dec 2011

Researchers present results from 31 major studies of blood-related cancers at ASH 2011 meeting

Researchers from the John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 best hospitals for cancer, presented results from 31 major studies of blood-related cancers - leukemia, lymphoma and multiple myeloma -- during the American Society of Hematology (ASH) Annual Meeting, December 10-13, 2011 in San Diego.

23 Dec 2011

D12-PGJ3 compound can cure leukemia

A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers. The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences.

23 Dec 2011

Study examines relationship between malaria, salmonella infection

People with malaria are more prone to developing bacterial infections, particularly from salmonella, and "researchers at the London School of Hygiene & Tropical Medicine [LSHTM] have discovered that the increased vulnerability to salmonella infections is a side effect of the body's attempts to protect itself from the damaging effects of the malaria infection," according to an LSHTM press release.

20 Dec 2011

Link between malaria and salmonella infections

The link between malaria and salmonella infections has been explained for the first time, opening the way to more effective treatments.

19 Dec 2011

Scientists identify how cells reduce tissue damage from inflammation in ALI model

Researchers at the University of Illinois at Chicago College of Medicine have found in an animal model of acute lung injury a molecular mechanism that allows cells of the immune system to reduce tissue damage from inflammation.

16 Dec 2011

Study evaluates use of leukocyte and platelet-rich fibrin biomaterial in heart patients

Cardiac patients that take anticoagulant medications and need a tooth extraction face an increased risk of bleeding that must be addressed by the treating clinician. Therefore, a protocol for heart patients is needed that will avoid significant bleeding after dental extractions without suspending anticoagulant therapy.

15 Dec 2011

Lab results change in consistent ways during the course of Kawasaki disease

Children with Kawasaki disease show a pattern of changing laboratory test results as the disease runs its course, according to a study in the December issue of The Pediatric Infectious Disease Journal.

15 Dec 2011

Novel prognostic model for patients with treatment-related MDS

A large-scale analysis of patients whose myelodysplastic syndrome is related to earlier cancer treatment overturns the notion that all of them have a poor prognosis, researchers from The University of Texas MD Anderson Cancer Center report at the 53rd Annual Meeting of the American Society of Hematology.

15 Dec 2011

Vorinostat in addition to chemotherapy drugs improves remission rates in AML patients

Adding a drug that activates genes to frontline combination therapy for acute myeloid leukemia resulted in an 85 percent remission rate after initial treatment, researchers at The University of Texas MD Anderson Cancer Center reported at the 53rd Annual Meeting of the American Society of Hematology.

14 Dec 2011

Scientists identify gene mutation behind Waldenstrom's macroglobulinemia

Scientists at Dana-Farber Cancer Institute have identified a gene mutation that underlies the vast majority of cases of Waldenstrom's macroglobulinemia, a rare form of lymphoma that has eluded all previous efforts to find a genetic cause.

13 Dec 2011

Leukocyte News and Research

ISU receives U.S. patent for phytol-derived adjuvant

Study shows how Notch gene and PRC2 protein complex work together to cause T-ALL

First details of genetic alterations that fuel early T-cell precursor ALL

Findings on cell working could lead to test and therapy for kidney failure caused by E. coli

Infectious disease-fighting drugs could be designed to block pathogen's entry into cells

MAL3-101 appears to have potent anti-tumor effects on multiple myeloma

RNF123 gene may play a role in major depression

Woman's ovarian cycle plays an important role in her susceptibility to infection

CEL-SCI to expand Multikine Phase III trial in head and neck cancer

CEL-SCI reports net loss of $26.8M for fiscal year ended September 30, 2011

Researchers present results from 31 major studies of blood-related cancers at ASH 2011 meeting

D12-PGJ3 compound can cure leukemia

Study examines relationship between malaria, salmonella infection

Link between malaria and salmonella infections

Scientists identify how cells reduce tissue damage from inflammation in ALI model

Study evaluates use of leukocyte and platelet-rich fibrin biomaterial in heart patients

Lab results change in consistent ways during the course of Kawasaki disease

Novel prognostic model for patients with treatment-related MDS

Vorinostat in addition to chemotherapy drugs improves remission rates in AML patients

Scientists identify gene mutation behind Waldenstrom's macroglobulinemia

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