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Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

3 Apr 2022

Experimental drug for hypertrophic cardiomyopathy reduces the need for invasive procedures, trial shows

Findings from a Cleveland Clinic-led clinical trial showed that the use of an experimental drug in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures.

2 Apr 2022

Convalescent plasma treatment for newly diagnosed COVID-19 patients may reduce hospitalization risk

Early treatment of newly diagnosed COVID-19 patients with plasma extracted from individuals who have recovered from the disease reduces the need for hospitalization by more than 50%, according to a new nationwide clinical trial.

31 Mar 2022

Results of Phase 3 Nanocovax SARS-CoV-2 vaccine trial suggest robust effectiveness

A new study presented the findings of the Phase 3 trial of the Nanocovax coronavirus disease 2019 (COVID-19) vaccine.

29 Mar 2022

Novel drug combination can boost chemoimmunotherapy response in bladder cancer patients

Adding an anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumor growth, according to a proof-of-concept study led by Cedars-Sinai Cancer investigators.

28 Mar 2022

Depression occurs independently of inflammation for many older people, study suggests

Multiple prior studies have found higher levels of inflammation in older individuals with depression. Now, a new Penn Medicine study has found that clinically depressed older individuals, on average, don't have elevated levels of inflammation if they don't already have other inflammatory conditions such as arthritis.

28 Mar 2022

Study evaluates efficacy of sarilumab in severe/critical COVID-19 patients

Researchers discuss the results of a clinical trial to assess the efficacy and safety of IV sarilumab for the treatment of hospitalized COVID-19 patients.

27 Mar 2022

New trial examines the effectiveness of a two-pronged immunotherapy for glioblastomas

A new clinical trial at the University of Cincinnati is studying the effectiveness of a new two-pronged immunotherapy treatment procedure to treat the most aggressive and deadly type of brain tumors, called glioblastomas. Originating from healthy brain cells, glioblastomas can form in any area of the brain.

25 Mar 2022

Tablet containing cannabidiol effectively reduces pain after shoulder surgery

An orally absorbed tablet containing cannabidiol (CBD) effectively reduces pain after shoulder surgery with no safety concerns, a new study finds.

25 Mar 2022

Study shows third dose of Pfizer-BioNTech vaccine against COVID-19 is both safe and effective

A research paper published in the New England Journal of Medicine has demonstrated how a third dose of Pfizer-BioNTech (BNT162b2) vaccine administered in a median period of 10.8 months after the second one bestowed 95.3% efficacy against coronavirus disease 2019 (COVID-19), in comparison with two doses of the same vaccine during a median follow-up of 2.5 months.

24 Mar 2022

Can melatonin gummies solve family bedtime struggles? Experts advise caution

For three exhausting years, Lauren Lockwood tried to get her son Rex to sleep through the night. As an infant, he couldn't sleep without a blanket over his carrier to drown out the world around him.

24 Mar 2022

Hydrocortisone does not prevent bronchopulmonary dysplasia in preterm infants

Hydrocortisone is no more effective than placebo at preventing damage that can result from oxygen and ventilator therapy necessary to keep preterm infants alive, according to research funded by the National Institutes of Health.

23 Mar 2022

Daily consumption of cranberries for one month improves cardiovascular function

A new clinical trial found daily consumption of cranberries for one month improved cardiovascular function in healthy men.

22 Mar 2022

A psychedelic drug plus psychotherapy could help improve PTSD symptoms

Post-traumatic stress disorder (PTSD) affects millions of people each year, mostly survivors and witnesses of terrifying or shocking events, such as warfare, assaults or disasters. Because existing treatments don't work for everyone, new therapies are urgently needed.

22 Mar 2022

Study evaluates the effectiveness of lactobacilli throat sprays against COVID-19

A recent study evaluated the effectiveness of lactobacilli throat sprays against COVID-19.

22 Mar 2022

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

A team of clinical investigators at the Icahn School of Medicine at Mount Sinai has announced the launch of a Phase 1, open-label, placebo-controlled study to evaluate the safety and immunogenicity of an egg-based COVID-19 vaccine in healthy, vaccinated adults who have never been infected with COVID-19.

21 Mar 2022

Phase 2 trial evaluates the safety and immunogenicity of two doses of the SARS-CoV-2 vaccine MVC-COV1901 in adolescents

A recent study evaluated the safety and immunogenicity of a COVID-19 vaccine in a phase II trial.

21 Mar 2022

University of Kentucky begins world’s first clinical trial for LATE

The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.

17 Mar 2022

Clinical utility of Roche assays determined utilizing samples from participants enrolled in a phase 2 trial of the mRNA-1273 vaccine

Researchers quantified the humoral immune response against the mRNA-1273 COVID-19 vaccine using commercially available high throughput assays.

17 Mar 2022

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Researchers reported the association of a single nucleotide polymorphism rs9984273 in the interferon-alpha/beta receptor gene with outcomes of acute respiratory distress syndrome and COVID-19.

17 Mar 2022

Placebo News and Research

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Experimental drug for hypertrophic cardiomyopathy reduces the need for invasive procedures, trial shows

Convalescent plasma treatment for newly diagnosed COVID-19 patients may reduce hospitalization risk

Results of Phase 3 Nanocovax SARS-CoV-2 vaccine trial suggest robust effectiveness

Novel drug combination can boost chemoimmunotherapy response in bladder cancer patients

Depression occurs independently of inflammation for many older people, study suggests

Study evaluates efficacy of sarilumab in severe/critical COVID-19 patients

New trial examines the effectiveness of a two-pronged immunotherapy for glioblastomas

Tablet containing cannabidiol effectively reduces pain after shoulder surgery

Study shows third dose of Pfizer-BioNTech vaccine against COVID-19 is both safe and effective

Can melatonin gummies solve family bedtime struggles? Experts advise caution

Hydrocortisone does not prevent bronchopulmonary dysplasia in preterm infants

Daily consumption of cranberries for one month improves cardiovascular function

A psychedelic drug plus psychotherapy could help improve PTSD symptoms

Study evaluates the effectiveness of lactobacilli throat sprays against COVID-19

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

Phase 2 trial evaluates the safety and immunogenicity of two doses of the SARS-CoV-2 vaccine MVC-COV1901 in adolescents

University of Kentucky begins world’s first clinical trial for LATE

Clinical utility of Roche assays determined utilizing samples from participants enrolled in a phase 2 trial of the mRNA-1273 vaccine

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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