DNA Sequencing News and Research

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New technique could dramatically lower costs of DNA sequencing

Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip.

16 Jan 2008

Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease

A new study by researchers at Hasbro Children's Hospital, the pediatric division of Rhode Island Hospital, and Mount Sinai Hospital, New York, offers new insight into the role that the cystic fibrosis gene plays in the development of gastrointestinal disease.

14 Dec 2007

Male infertility - epigenetics may be the underlying cause

Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility.

13 Dec 2007

$1.7 million grant to advance understanding of genetic influences on diabetes

Scientists at Southwest Foundation for Biomedical Research (SFBR) expect to make big leaps in their understanding of genetic influences on diabetes, thanks to a new $1.7 million grant awarded to Dr. Joanne Curran, the grant's principal investigator.

13 Dec 2007

New quicker technique for sequencing DNA

13 Dec 2007

More regulatory DNA than previously thought

Surrounding the small islands of genes within the human genome is a vast sea of mysterious DNA. While most of this non-coding DNA is junk, some of it is used to help genes turn on and off.

13 Dec 2007

Losses of long-established genes contribute to human evolution

While it is well understood that the evolution of new genes leads to adaptations that help species survive, gene loss may also afford a selective advantage.

13 Dec 2007

New test for targeted therapy in acute myeloid leukemia

Oregon Health & Science University Cancer Institute researcher Jeff Tyner, Ph.D., has created a way to identify proteins that are candidates for targeted therapy in acute myeloid leukemia using an assay that yields results in just four days.

10 Dec 2007

DNA methylation shown to promote development of colon tumors

Damaged or defective genes have long been known to be the cause of some cancers.

2 Dec 2007

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration

Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.

14 Nov 2007

Newly completed genome sequence may provide new treatment options for dandruff

Scientists from P&G Beauty announced that they successfully sequenced the complete genome for Malassezia globosa (M. globosa) , a naturally occurring fungus responsible for the onset of dandruff and other skin conditions in humans.

6 Nov 2007

New view of lung cancer genome

An international team of scientists, supported in part by the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), have announced that its systematic effort to map the genomic changes underlying lung cancer has uncovered a critical gene alteration not previously linked to any form of cancer.

5 Nov 2007

Comprehensive view of the abnormal genetic landscape in lung cancer cells

An international team of scientists has announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world's leading cause of cancer deaths.

5 Nov 2007

Genetics of alcoholism

While both environmental and genetic factors contribute to the risk of developing alcohol dependence, it is believed to be a largely heritable – 52 to 64 percent – disease.

24 Oct 2007

New genetic and phenotypic data involved in autism released to researchers worldwide

The Autism Consortium, a group of researchers, clinicians and families dedicated to radically accelerating research and enhancing clinical care for autism, announced today that it has completed the first genome scan for Autism Spectrum Disorders (ASD) through its Autism Gene Discovery Project and has released the reference data set to a database that autism researchers around the world can use.

22 Oct 2007

Massive reanalysis of genome data solves case of the lethal genes

It is better to be looked over than overlooked, Mae West supposedly said. These are words of wisdom for genome data-miners of today.

19 Oct 2007

Discovery on human individuality and maternal and paternal DNA

Have you ever wondered why you inherited your mother's smile but not your father's height?

18 Oct 2007

Direct selection of human genomic loci by microarray hybridization

Researchers at Baylor College of Medicine and Roche NimbleGen Inc., a fully integrated part of Roche Applied Science, have published details of a highly efficient and cost-effective method for capturing targeted regions of the genome via NimbleChip microarrays in preparation for high-throughput 454 Sequencing.

16 Oct 2007

HiFi DNA Tech files lawsuit against FDA

A lawsuit was filed Oct. 12 in U.S. District Court against the U.S. Department of Health and Human Services (HHS) and the U.S. Food and Drug Administration (FDA) related to reclassification of HPV DNA tests from class III to class II devices. The inaction by both agencies hinders introduction of new and affordable HPV testing to improve women’s health care.

15 Oct 2007

Microarray-based genomic selection accelerates discovery of subtle DNA variations

A new technology developed by scientists at Emory University will allow researchers to more easily discover subtle and overlooked genetic variations that may have serious consequences for health and disease.

15 Oct 2007