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Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial cell cycle progression.

8 Nov 2024

Spatial transcriptomics uncovers tissue niches in multiple sclerosis

Mapping cell types in MS lesions reveals unique tissue niches and interactions, offering insights into the molecular drivers of multiple sclerosis progression.

8 Nov 2024

Preeclampsia and COVID-19 share pathophysiological similarities in pregnant women

During the COVID-19 pandemic, above all before vaccines were available, an alarm was sounded regarding a possible correlation between severe cases of COVID-19 in pregnant women and preeclampsia, a condition characterized by high blood pressure (hypertension) in the expectant mother and high levels of protein in her urine (proteinuria). It can entail dangerous complications for mother and baby.

7 Nov 2024

Virtual screening yields small molecules to enhance cancer immunotherapy

The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers.

7 Nov 2024

Could vitamin D help COVID-19 patients? Meta-analysis highlights potential ICU reduction

Vitamin D may lower ICU and intubation rates in COVID-19 patients, with significant benefits observed in older and severe cases, according to recent research.

7 Nov 2024

Anti-inflammatory cytokine linked to capillary obstruction and cognitive decline in diabetes

Elevated IL-10 in diabetes causes capillary obstruction, linked to cognitive deficits. Blocking IL-10 receptors shows promise for improving brain function.

7 Nov 2024

Researchers uncover immune mechanism behind myocarditis from cancer immunotherapy

Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis.

6 Nov 2024

Werner syndrome gene plays key role in maintaining cellular organization and DNA stability

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 20 on October 17, 2024, entitled, "Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells."

5 Nov 2024

New technology for visualizing AMPA receptors offers insights into psychiatric disorders

Even though psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder (ASD) are quite common, their diagnosis and treatment are challenging.

5 Nov 2024

Modulating CD39 expression to enhance CAR-T cell therapy against hepatocellular carcinoma

In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a recent study has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells.

5 Nov 2024

New insights into early Huntington's disease mechanisms

Researchers uncover a link between impaired glutathione–ascorbate metabolism and early dopamine increases in Huntington's disease, suggesting GSTO2 as a potential therapeutic target to manage motor dysfunction.

4 Nov 2024

Weight loss drug semaglutide may offer relief for knee arthritis pain

Semaglutide shows promise in treating knee osteoarthritis by reducing pain and weight, offering a safe alternative to traditional pharmacological interventions.

4 Nov 2024

Combination therapy shows promising results in treating stage 3 melanoma

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

1 Nov 2024

Critical protein linked to spillover potential of animal viruses

Scientists investigating animal viruses with potential to infect humans have identified a critical protein that could enable spillover of a family of organisms called arteriviruses.

1 Nov 2024

New therapeutic target overcomes ovarian cancer immunotherapy resistance

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance.

1 Nov 2024

New technology streamlines drug discovery using single-molecule tracking

New drug discovery is a critical step for improving patients' lives. First, researchers must identify molecules in the body's cells that help drive disease, as these are potential targets for new drugs. The next step is to screen candidate drugs that can hit those targets.

1 Nov 2024

Receptor News and Research

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Spatial transcriptomics uncovers tissue niches in multiple sclerosis

Preeclampsia and COVID-19 share pathophysiological similarities in pregnant women

Virtual screening yields small molecules to enhance cancer immunotherapy

Could vitamin D help COVID-19 patients? Meta-analysis highlights potential ICU reduction

Anti-inflammatory cytokine linked to capillary obstruction and cognitive decline in diabetes

Researchers uncover immune mechanism behind myocarditis from cancer immunotherapy

Werner syndrome gene plays key role in maintaining cellular organization and DNA stability

New technology for visualizing AMPA receptors offers insights into psychiatric disorders

Modulating CD39 expression to enhance CAR-T cell therapy against hepatocellular carcinoma

New insights into early Huntington's disease mechanisms

Weight loss drug semaglutide may offer relief for knee arthritis pain

Combination therapy shows promising results in treating stage 3 melanoma

Critical protein linked to spillover potential of animal viruses

New therapeutic target overcomes ovarian cancer immunotherapy resistance

New technology streamlines drug discovery using single-molecule tracking

The crucial role of sleep in heart healing

Semaglutide reduces urine albumin-to-creatinine ratio in overweight chronic kidney disease patients

Weill Cornell Medicine teams receive funding from Starr Cancer Consortium

Understanding protein transport mechanisms could enhance crop yields

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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