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First case of treating cystic fibrosis and Crohn's disease with infliximab

Cystic fibrosis (CF) is the most common life-threatening autosomal recessive disease in Caucasian children; it has an incidence of 1 case in every 2500 children born alive. CF involves an anomalous function of the exocrine glands, caused by a mutation of a gene (cystic fibrosis transmembrane conductance regulator, CFTR) located on chromosome 7, which codes for a protein involved in ion transport through the cell membrane.

20 Apr 2010

UAB researchers discover four miRNAs to assess survival rate of colorectal cancer patients

Researchers at the University of Alabama at Birmingham Department of Pathology have discovered a set of four biomarkers that will help predict which patients are more likely to develop aggressive colorectal cancer and which are not. The findings also shed light on the genetics that result in worse colorectal cancer-treatment outcomes for African-Americans, compared with Caucasians, the researchers said.

20 Apr 2010

Positive data from NewLink Genetics Phase1/2 study of HyperAcute-Lung cancer immunotherapy

NewLink Genetics Corporation announced today data from a Phase 1/2 study showing that patients with progressive advanced non-small cell lung cancer treated with its HyperAcute®-Lung cancer immunotherapy experienced favorable median survival. The data were presented at the 101st American Association for Cancer Research (AACR) Annual Meeting.

20 Apr 2010

Momenta Pharmaceuticals presents preclinical data of M402 at AACR 2010

Momenta Pharmaceuticals, Inc., a biotechnology company specializing in the characterization and engineering of complex mixture drugs, today announced presentation of results from a preclinical study of its novel oncology drug candidate, M402, in a murine pancreatic cancer model.

20 Apr 2010

FDA-approved metformin can prevent tobacco-carcinogen induced lung tumors: Study

Metformin, a mainstay of treatment for patients with type 2 diabetes, may soon play a role in lung cancer prevention if early laboratory research presented here at the AACR 101st Annual Meeting 2010 is confirmed in clinical trials.

20 Apr 2010

New research shows link between infection-related diseases and risk of cancer

New research is emerging that suggests a link between infection-related diseases and risk of cancer, according to findings presented here at the American Association for Cancer Research 101st Annual Meeting 2010.

20 Apr 2010

LSF gene plays important role in development and progression of HCC: VCU researchers

Virginia Commonwealth University researchers have identified a new tumor-promoting gene that may play a key role in the development of liver cancer. Levels of the gene's expression are significantly higher in more than 90 percent of patients with the disease compared to their healthy counterparts.

20 Apr 2010

Updated survival data from Phase I/II trial of nab-paclitaxel, gemcitabine combination for pancreatic cancer

Abraxis BioScience, Inc., a fully integrated biotechnology company, today announced updated overall survival findings from a phase I/II study of nab®-paclitaxel (ABRAXANE® for Injectable Suspension) (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) given in combination with gemcitabine, demonstrated increased survival of the first-line treatment of patients with advanced pancreatic cancer.

19 Apr 2010

"Brain Port" surgery helps remove colloid cyst in 15-week pregnant woman

A unique device developed to make brain surgery easier and less traumatic has been successfully used on a patient who was pregnant and suffering from a potentially life-threatening brain cyst. The device, called a "Brain Port," was pioneered by renowned neurosurgeon Amin Kassam, MD, Medical Director of the Neuroscience Institute at Saint John's Health Center.

19 Apr 2010

Biomarkers to help predict development of aggressive colorectal cancer discovered

Researchers at the University of Alabama at Birmingham (UAB) Department of Pathology have discovered a set of four biomarkers that will help predict which patients are more likely to develop aggressive colorectal cancer and which are not. The findings also shed light on the genetics that result in worse colorectal cancer-treatment outcomes for African-Americans, compared with Caucasians, the researchers said.

19 Apr 2010

Caliper Life Sciences introduces Quantum FX stand-alone microCT system for preclinical imaging

Caliper Life Sciences, Inc., a leading provider of tools and services for drug discovery, life sciences research and molecular diagnostics, today announced the Quantum FX, a stand-alone microCT system for preclinical imaging. Introduced at the American Association for Cancer Research Annual Meeting 2010, the Quantum FX is a low dose, microCT system that provides researchers with a 3-dimensional anatomical view of disease activity, tumor development and therapeutic response over multiple time points during the course of a study.

19 Apr 2010

Stanford researchers discover tissue-specific target in pathogen

A tumor-causing maize fungus with the unsavory-sounding name "corn smut" wields different weapons from its genetic arsenal depending on which part of the plant it infects. The discovery by Stanford researchers marks the first time tissue-specific targeting has been found in a pathogen.

19 Apr 2010

Radiolabeled hedgehog can differentiate stem-like cancer cells, identify aggressive tumors

At the American Association for Cancer Research 101st Annual Meeting 2010, scientists and clinicians will present more than 6,300 abstracts dealing with innovative aspects of biology, technology and emerging therapies.

19 Apr 2010

New p53 knockout rat model improves timelines for carcinogenicity screening

Sigma Life Science, the innovative biological products and services brand of Sigma-Aldrich, today introduced the world's first p53 'knockout' rat model, an important development that is expected to, due to the rat's closer physiological and metabolic similarity to humans, significantly improve timelines for carcinogenicity screening and reduce time to market for therapeutics.

19 Apr 2010

Amgen announces results from pivotal Phase 3 "408" trial of Vectibix

Amgen today announced detailed results from a new biomarker analysis of the pivotal Phase 3 "408" trial of Vectibix® (panitumumab) plus best supportive care compared to BSC alone. The analysis used massively parallel, next-generation sequencing technology to investigate whether mutations in nine genes known to be mutated in colorectal cancer, including the previously unanalyzed exon 3 mutation of the KRAS gene, are predictive of response to Vectibix in metastatic colorectal cancer.

19 Apr 2010

Results of BATTLE Trial presented at AACR 2010

Lung cancer is the number one cause of cancer death in men and women, but huge randomized trials of thousands of patients have either failed completely or shown negligible survival differences.

19 Apr 2010

Clues to molecular markers on breast tumors that may predict spread of lymph node cancer

Predicting breast cancer spread from a sentinel lymph node removed during surgery is a hit or miss affair, say researchers: there are still many false negatives, which means the node, when analyzed under a microscope, appears clean of cancer cells, but metastasis can still occur in the patient. The sentinel node is the first lymph node in the axilla that cancer spreads to.

19 Apr 2010

Role of lactate in breast cancer development to be showcased at AACR 2010

Does lactate play a role in the metabolic fate of cancer cells? Researchers from The Cancer Institute of New Jersey are in Washington, D.C., this week for the 101st Annual Meeting of the American Association for Cancer Research to share their findings on what role this common energy byproduct in the body plays in the development of breast cancer cells and surrounding connective tissue.

19 Apr 2010

Pre-clinical data on MM-121 and MM-111 to be presented at AACR 2010

Merrimack Pharmaceuticals, Inc. announced today that it will present pre-clinical data on MM-121 and MM-111, the two lead candidates in the company's pipeline of five novel cancer antibodies, at the 101st Annual Meeting of the American Association for Cancer Research (AACR) being held April 17 – 21, 2010, in Washington, D.C.

17 Apr 2010

Honey beneficial for treatment of fungating tumor wounds

Surviving cancer is physically and emotionally exhausting. But for many patients, beating the disease itself is just the first hurdle. A second ordeal comes from living with the fungating tumor wounds that accompany various cancers. Aside from the pain they inflict, these wounds often emit a strong and offensive odor. Not only does going into public become potentially embarrassing, but it also can be extremely depressing when even close family members are repulsed by the smell.

17 Apr 2010

Tumor News and Research

First case of treating cystic fibrosis and Crohn's disease with infliximab

UAB researchers discover four miRNAs to assess survival rate of colorectal cancer patients

Positive data from NewLink Genetics Phase1/2 study of HyperAcute-Lung cancer immunotherapy

Momenta Pharmaceuticals presents preclinical data of M402 at AACR 2010

FDA-approved metformin can prevent tobacco-carcinogen induced lung tumors: Study

New research shows link between infection-related diseases and risk of cancer

LSF gene plays important role in development and progression of HCC: VCU researchers

Updated survival data from Phase I/II trial of nab-paclitaxel, gemcitabine combination for pancreatic cancer

"Brain Port" surgery helps remove colloid cyst in 15-week pregnant woman

Biomarkers to help predict development of aggressive colorectal cancer discovered

Caliper Life Sciences introduces Quantum FX stand-alone microCT system for preclinical imaging

Stanford researchers discover tissue-specific target in pathogen

Radiolabeled hedgehog can differentiate stem-like cancer cells, identify aggressive tumors

New p53 knockout rat model improves timelines for carcinogenicity screening

Amgen announces results from pivotal Phase 3 "408" trial of Vectibix

Results of BATTLE Trial presented at AACR 2010

Clues to molecular markers on breast tumors that may predict spread of lymph node cancer

Role of lactate in breast cancer development to be showcased at AACR 2010

Pre-clinical data on MM-121 and MM-111 to be presented at AACR 2010

Honey beneficial for treatment of fungating tumor wounds

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