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How early interferon curbs SARS-CoV-2 infection

A new study available in the Journal of Experimental Medicine focuses on the importance of interferon in SARS-CoV-2 infection.

30 Aug 2021

More than 80% of hypertension cases now found in poorer countries

More than half a billion people worldwide live with undetected, untreated hypertension, even as the disease burden shifts from rich nations to poor countries with limited resources to detect and manage the condition.

30 Aug 2021

Researchers study the role of low-density granulocytes in COVID-19

Information on granulocytes helps to understand mechanisms associated with covid-19 and other infectious diseases. Such information also promotes the development of better diagnostic methods and therapies.

30 Aug 2021

UH associate professor receives $2.5 million to explore how arterial hardening starts within cells

In diseases such as hypertension, aging, atherosclerosis, diabetes and chronic kidney disease, arterial calcification and stiffening of the elastic layer of the arterial wall are almost always present.

30 Aug 2021

Intensive blood-pressure control benefits older hypertensive patients

Aggressive blood pressure treatment in older hypertensive patients lowers the incidence of cardiovascular events compared to standard therapy, without increasing adverse outcomes. That's the finding of late breaking research presented in a Hot Line session today at ESC Congress 2021.

30 Aug 2021

‘My time to live’: Through novel program, kidney patients get palliative care, dialysis ’til the end

After a decade of living with chronic kidney disease, Vonita McGee knows her body is wearing out.

30 Aug 2021

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Although epilepsy is a relatively common condition, affecting approximately 1% of individuals worldwide, it is often difficult to diagnose in clinical practice, and it is estimated that up to a quarter of all cases may be misdiagnosed initially.

30 Aug 2021

Combination therapy given in fixed doses can cut risk of cardiovascular disease by more than half

A combination therapy of aspirin, statins and at least two blood pressure medications given in fixed doses can slash the risk of fatal cardiovascular disease (CVD) by more than half, says an international study led by Hamilton researchers.

30 Aug 2021

Screening for atrial fibrillation in the elderly could help avoid stroke and death

Screening for atrial fibrillation in 75- and 76-year-olds could reduce the risk of stroke, severe bleeding and death, according to a study at Karolinska Institutet in Sweden that has been published in the journal The Lancet.

30 Aug 2021

Daily walnut consumption lowers LDL cholesterol levels and may promote cardiovascular health

Eating about ½ cup of walnuts every day for two years modestly lowered levels of low-density lipoprotein (LDL) cholesterol, known as "bad cholesterol," and reduced the number of total LDL particles and small LDL particles in healthy, older adults, according to new research published today in the American Heart Association's flagship journal Circulation.

30 Aug 2021

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

The underlying cause of sudden cardiac death (SCD) in a young person is often difficult to identify. A genetic analysis could provide more information in many cases, but blood samples are not collected routinely at the time of death, and DNA extracted from the tissues collected at autopsy is damaged because of the way they are fixed in formalin and paraffin-embedded.

30 Aug 2021

New study analyzes altered gene expression in severe COVID-19

In a paper recently uploaded to the bioRxiv* preprint server, the genetic link between COVID-19 severity and gene expression is investigated, hoping to allow early identification of otherwise healthy individuals that will likely require hospitalization if infected.

30 Aug 2021

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Recently, a new study published on the pre-print server bioRxiv* examined the effect that maternal asymptomatic COVID-19 had on decidual and peripheral immune cells during the later stage of pregnancy.

30 Aug 2021

$Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction$

Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction

Until now, patients with heart failure with preserved ejection fraction – the most common type of heart failure in the elderly – have had no access to evidenced-based treatments. For the first time, a large clinical trial led by Prof. Dr. Stefan Anker from Charité – Universitätsmedizin Berlin has identified a drug which has a distinctly positive effect on prognosis. In patients affected by this type of heart failure, the drug – empagliflozin – reduces the risk of hospitalization or cardiovascular death by 21 percent. The results of this research have been published in the New England Journal of Medicine.

28 Aug 2021

New ESC/EACTS guidelines for the management of valvular heart disease published

The European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery Guidelines for the management of valvular heart disease are published online today in European Heart Journal.

28 Aug 2021

Moderate-vigorous physical activity found to be the most efficient at improving fitness

In the largest study performed to date to understand the relationship between habitual physical activity and physical fitness, researchers from Boston University School of Medicine (BUSM) have found that higher amount of time spent performing exercise (moderate-vigorous physical activity) and low-moderate level activity (steps) and less time spent sedentary, translated to greater physical fitness.

28 Aug 2021

Cognitive function of older adults could be improved through multidomain lifestyle interventions

Aging-US published "Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial" which reported that in an outcome assessor-blinded, randomized controlled trial, participants without dementia and with one or more modifiable dementia risk factors, aged 60-79 years, were randomly assigned to the facility-based MI, the home-based MI, or the control group receiving general health advice.

28 Aug 2021

Study may pave way for new treatment strategies to limit the progression of solid tumors

Researchers at the University of British Columbia's faculty of medicine and BC Cancer Research Institute have uncovered a weakness in a key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low.

28 Aug 2021

Study opens up a new approach to incorporating MRI into multisite pancreatic clinical trials

Researchers with the Vanderbilt Diabetes Research and Training Center (DRTC) at Vanderbilt University Medical Center led a multisite study which has demonstrated that, when controlled and standardized, quantitative magnetic resonance imaging (MRI) of the pancreas is highly reproducible when using different MRI hardware and software at different geographic locations.

28 Aug 2021

Pfizer COVID-19 jab side effects likely to be mild to moderate in extremely vulnerable 12-15 year olds

The side effects of the Pfizer-BioNTech jab against COVID-19 are likely to be mild to moderate and clear up quickly in 12-15 year olds at high risk of complications from the infection because of certain coexisting conditions, reveals a small study accepted for publication in the Archives of Disease in Childhood.

28 Aug 2021

Blood News and Research

How early interferon curbs SARS-CoV-2 infection

More than 80% of hypertension cases now found in poorer countries

Researchers study the role of low-density granulocytes in COVID-19

UH associate professor receives $2.5 million to explore how arterial hardening starts within cells

Intensive blood-pressure control benefits older hypertensive patients

‘My time to live’: Through novel program, kidney patients get palliative care, dialysis ’til the end

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Combination therapy given in fixed doses can cut risk of cardiovascular disease by more than half

Screening for atrial fibrillation in the elderly could help avoid stroke and death

Daily walnut consumption lowers LDL cholesterol levels and may promote cardiovascular health

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

New study analyzes altered gene expression in severe COVID-19

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction

New ESC/EACTS guidelines for the management of valvular heart disease published

Moderate-vigorous physical activity found to be the most efficient at improving fitness

Cognitive function of older adults could be improved through multidomain lifestyle interventions

Study may pave way for new treatment strategies to limit the progression of solid tumors

Study opens up a new approach to incorporating MRI into multisite pancreatic clinical trials

Pfizer COVID-19 jab side effects likely to be mild to moderate in extremely vulnerable 12-15 year olds

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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