Immune System News and Research

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Pergamum initiates LL-37 Phase I/II trial in hard-to-heal venous leg ulcers

Pergamum AB announced today that dosing has begun in a randomized Phase I/II trial of LL-37 for the treatment of patients with hard-to-heal venous leg ulcers.

11 Sep 2012

Researchers discover small DNA sequence that drives GATA2 protein

The protein GATA2 is known as a "master regulator" of blood cell development. When a mutation occurs in the gene that makes GATA2, serious blood diseases such as acute myeloid leukemia can result.

11 Sep 2012

Data from Sangamo BioSciences’ SB-728-T Phase 1 clinical programs on HIV/AIDS

Sangamo BioSciences, Inc. announced that data from its Phase 1 clinical programs to develop SB-728-T, a novel therapeutic approach designed to generate a "functional cure" for HIV/AIDS, were presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

11 Sep 2012

Combining two drugs may offer new and potent punch against cancer and other diseases

A new study by researchers at Weill Cornell Medical College shows combining two already-FDA approved drugs may offer a new and potent punch against diseases in which blood vessel growth is abnormal -- such as cancer, diabetic retinopathy, macular degeneration and rheumatoid arthritis.

11 Sep 2012

Oxyphenbutazone can kill drug resistant TB

An off-patent anti-inflammatory drug that costs around two cents for a daily dose in developing countries has been found by researchers at Weill Cornell Medical College to kill both replicating and non-replicating drug resistant tuberculosis in the laboratory -- a feat few currently approved TB drugs can do, and resistance to those is spreading.

11 Sep 2012

HIV viruses with two genetic 'footprints' associated with greater vaccine efficacy

Scientists used genetic sequencing to discover new evidence that the first vaccine shown to prevent HIV infection in people also affected the viruses in those who did become infected. Viruses with two genetic "footprints" were associated with greater vaccine efficacy. The results were published today in the online edition of the journal Nature.

10 Sep 2012

Automated system for mapping protein-DNA interactions

Since the sequencing of the human genome in 2001, all our genes - around 20,000 in total - have been identified. But much is still unknown - for instance where and when each is active. Next to each gene sits a short DNA segment, and the activity of this regulatory segment determines whether the gene will be turned on, where and how strongly.

10 Sep 2012

Atox Bio AB103 for Necrotizing Soft Tissue Infections granted FDA Fast Track designation

Atox Bio, a clinical stage biotechnology company engaged in the development of novel immunemodulators for severe infections in critically ill patients, announced today that the U.S. Food and Drug Administration has granted Fast Track designation to AB103, its lead product, currently in development for the treatment of Necrotizing Soft Tissue Infections (NSTI).

10 Sep 2012

Data from BioLineRx’s BL-7010 pre-clinical studies on celiac disease

BioLineRx, a biopharmaceutical development company, announced today that BL-7010, an orally available treatment for celiac disease, was found to be safe and well tolerated in pre-clinical studies conducted to date.

10 Sep 2012

Researchers identify many potential therapeutic targets for squamous cell lung cancers

A new paper published online in Nature holds out hope that people with the second most common type of lung cancer may one day benefit from targeted therapies that have transformed treatments for other lung cancer patients.

10 Sep 2012

Surprising new roles for angiotensin converting enzyme

At the 1st ECRC "Franz-Volhard" Symposium on September 7, 2012 at the Max Delbr-ck Center for Molecular Medicine (MDC) in Berlin-Buch, Professor Ken Bernstein reported that in mice an excess of ACE led to a much stronger immune response than usual.

10 Sep 2012

Researchers identify genetic variations linked with onset of Barrett's oesophagus

Genetic variations that are linked with the onset of Barrett's oesophagus (BE), a pre-cancerous condition of the lower end of the gullet, have been identified for the first time. The discovery of variations in regions on two chromosomes makes it possible to develop screening tests for people at high risk of developing the disease.

10 Sep 2012

New oral antiseptic spray effective in killing 99.9% of infectious airborne germs

University Hospitals Case Medical Center clinical researchers will present findings about a one-two punch to prevent colds and flu in San Francisco at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) on Sept. 9.

10 Sep 2012

Researchers identify three genetic regions associated with primary biliary cirrhosis

Researchers have newly identified three genetic regions associated with primary biliary cirrhosis (PBC), the most common autoimmune liver disease, increasing the number of known regions associated with the disorder to 25.

10 Sep 2012

Skin, immune system play an important role in regulating sodium balance and hypertension

High blood pressure is responsible for many cardiovascular diseases that are the leading cause of death in industrialized countries. High salt intake has long been considered a risk factor, but not every type of high blood pressure is associated with high salt intake. This has puzzled scientists for a long time. However, new findings by Professor Jens Titze (Vanderbilt University, Nashville, Tennessee, USA and the University of Erlangen) now point to previously unknown mechanisms.

10 Sep 2012

UK public oppose cancer drugs fund but support new pricing system for branded medicines

The public oppose the cancer drugs fund but support the new pricing system for branded medicines, according to a new study.

10 Sep 2012

Outbreak of autoimmune disease with AIDS-like symptoms in Southeast Asia

There has been an outbreak of an adult-onset immunodeficiency syndrome in Southeast Asia. The autoimmune disease causes AIDS-like symptoms but is not associated with HIV and is not contagious.

7 Sep 2012

Therapeutic targets for pemphigus vulgaris discovered

Researchers have identified the primary target of the autoantibodies found in the serum of patients with the blistering skin disorder pemphigus vulgaris.

7 Sep 2012

Children and young patients with chronic HBV infection do have a protective immune response

Scientists from A*STAR's Singapore Institute for Clinical Sciences (SICS), together with clinical collaborators from London , discovered for the first time that children and young patients with chronic Hepatitis B Virus infection (HBV carriers) do have a protective immune response, contrary to current belief, and hence can be more suitable treatment candidates than previously considered.

7 Sep 2012

Biopsies may misdiagnose eosinophilic esophagitis

University of Utah engineers mapped white blood cells called eonsinophils and showed an existing diagnostic method may overlook an elusive digestive disorder that causes swelling in the esophagus and painful swallowing.

7 Sep 2012

Immune System News and Research

Pergamum initiates LL-37 Phase I/II trial in hard-to-heal venous leg ulcers

Researchers discover small DNA sequence that drives GATA2 protein

Data from Sangamo BioSciences’ SB-728-T Phase 1 clinical programs on HIV/AIDS

Combining two drugs may offer new and potent punch against cancer and other diseases

Oxyphenbutazone can kill drug resistant TB

HIV viruses with two genetic 'footprints' associated with greater vaccine efficacy

Automated system for mapping protein-DNA interactions

Atox Bio AB103 for Necrotizing Soft Tissue Infections granted FDA Fast Track designation

Data from BioLineRx’s BL-7010 pre-clinical studies on celiac disease

Researchers identify many potential therapeutic targets for squamous cell lung cancers

Surprising new roles for angiotensin converting enzyme

Researchers identify genetic variations linked with onset of Barrett's oesophagus

New oral antiseptic spray effective in killing 99.9% of infectious airborne germs

Researchers identify three genetic regions associated with primary biliary cirrhosis

Skin, immune system play an important role in regulating sodium balance and hypertension

UK public oppose cancer drugs fund but support new pricing system for branded medicines

Outbreak of autoimmune disease with AIDS-like symptoms in Southeast Asia

Therapeutic targets for pemphigus vulgaris discovered

Children and young patients with chronic HBV infection do have a protective immune response

Biopsies may misdiagnose eosinophilic esophagitis

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