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Understanding the novel coronavirus genome

The novel coronavirus emerged in December 2019 in Wuhan City, Hubei Province, in China, and since then, it has rapidly spread to over 170 countries across the globe. Our knowledge of the virus, now officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still in the early stages. However, scientists around the world are racing to better understand the virus, in the hope of shedding light on potential vaccines and therapies.

31 Mar 2020

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder

The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol to near-normal levels among patients with a rare cholesterol disorder, meeting the primary endpoint in the first randomized placebo-controlled trial of the drug, which is being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

31 Mar 2020

Researchers develop chemically modified phage capsid that “stifles” influenza viruses

A new approach brings the hope of new therapeutic options for suppressing seasonal influenza and avian flu: On the basis of an empty - and therefore non-infectious - shell of a phage virus, researchers from Berlin have developed a chemically modified phage capsid that "stifles" influenza viruses.

31 Mar 2020

Temple researchers reverse muscle fibrosis associated with overuse injury in animals

Overuse injuries - think muscle strains, tennis elbow, and rotator cuff tears - are a considerable problem in the United States, especially among young athletes.

30 Mar 2020

Origins of SARS-CoV-2 – natural or man-made?

With over 780,000 individuals across the world infected and over 37,000 dead, the world is gripped by the pandemic caused by the novel strain of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

30 Mar 2020

Direct oral anticoagulant more effective in lowering risk of VTE after common orthopedic surgeries

The direct oral anticoagulant rivaroxaban dramatically cut the likelihood of serious venous thromboembolism (VTE) in people recovering from lower limb orthopedic surgery requiring immobilization in comparison with enoxaparin, another anticoagulant agent, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

'Living drug factories' could be used to achieve long-term treatment of chronic diseases

One promising way to treat diabetes is with transplanted islet cells that produce insulin when blood sugar levels get too low.

30 Mar 2020

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

The cholesterol drug alirocumab reduced low-density lipoprotein (LDL) cholesterol by 35.6% compared to placebo in adult patients with homozygous familial hypercholesterolemia (HoFH), according to a phase three clinical trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

AI tool could accurately predict which COVID-19 patients will develop respiratory disease

An artificial intelligence tool accurately predicted which patients newly infected with the COVID-19 virus would go on to develop severe respiratory disease, a new study found.

30 Mar 2020

Study reveals new mechanism underlying organelle communication in brown fat cells

In recent years, brown fat has garnered increasing attention as the so-called good fat that can protect against obesity and associated health risks, like cardiovascular disease and diabetes.

30 Mar 2020

Moffitt scientists identify potential therapeutic targets for cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cuSCC) is the second most common diagnosed malignancy in the United States, with approximately 700,000 new cases each year.

30 Mar 2020

Revita DMR therapy has potential to transform lives of patients with poorly controlled type 2 diabetes

Patients with poorly controlled type 2 diabetes who underwent a novel, minimally invasive, endoscopic procedure called Revita duodenal mucosal resurfacing had significantly improved blood glucose (sugar) levels, liver insulin sensitivity, and other metabolic measures three months later, according to new data from the REVITA-2 study.

30 Mar 2020

Weakness in lung and kidney cancer cells could serve as therapeutic target

An important discovery about how some cancers rely on glucose to survive could lead to development of tumor-specific treatments.

30 Mar 2020

How long to a coronavirus vaccine?

The whole world is waiting for one. A vaccine is the only thing that could conceivably save the world from a horrifying cascade of deaths, other than a miracle, it seems.

29 Mar 2020

Gene that could affect the progress of ALS discovered

Researchers from the Zuckerman Institute at Columbia University have successfully found a gene that could work towards accelerating the progression of ALS or amyotrophic lateral sclerosis. The study titled, "The loss of TBK1 kinase activity in motor neurons or in all cell types differentially impacts ALS disease progression in SOD1 mice," was published in the latest issue of the journal Neuron.

29 Mar 2020

COVID-19 and its effects on the cardiovascular system

Researcher have reviewed the evidence showing the effects of the SARS-CoV-2 or novel coronavirus infection (COVID-19) on the cardiovascular system. Their study titled, “Potential Effects of Coronaviruses on the Cardiovascular System: A Review,” was published in the latest issue of JAMA Cardiology.

29 Mar 2020

New in vivo priming strategy can be an effective means to enhance cardiac repair

Human stem cells have been regarded as one of the promising cell sources for cardiac regeneration therapy.

27 Mar 2020

Genetic mutation found to improve cognitive flexibility in mice

Researchers at the National Institutes of Health have discovered in mice what they believe is the first known genetic mutation to improve cognitive flexibility--the ability to adapt to changing situations.

27 Mar 2020

Heart and kidney patients should keep taking their medicines during COVID-19 pandemic

As the COVID-19 pandemic unfolds, inaccurate medical information has flooded social media and other channels.

27 Mar 2020

Researchers enlist the help of citizen scientists to design new drugs against coronavirus

The best thing most of us can do to fight COVID-19 is stay home, to curb the respiratory disease's spread. But anyone with a computer can pitch in more actively too: by helping scientists design drugs to combat the virus now responsible for hundreds of thousands of infections worldwide.

27 Mar 2020

Protein C News and Research

Understanding the novel coronavirus genome

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder

Researchers develop chemically modified phage capsid that “stifles” influenza viruses

Temple researchers reverse muscle fibrosis associated with overuse injury in animals

Origins of SARS-CoV-2 – natural or man-made?

Direct oral anticoagulant more effective in lowering risk of VTE after common orthopedic surgeries

'Living drug factories' could be used to achieve long-term treatment of chronic diseases

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

AI tool could accurately predict which COVID-19 patients will develop respiratory disease

Study reveals new mechanism underlying organelle communication in brown fat cells

Moffitt scientists identify potential therapeutic targets for cutaneous squamous cell carcinoma

Revita DMR therapy has potential to transform lives of patients with poorly controlled type 2 diabetes

Weakness in lung and kidney cancer cells could serve as therapeutic target

How long to a coronavirus vaccine?

Gene that could affect the progress of ALS discovered

COVID-19 and its effects on the cardiovascular system

New in vivo priming strategy can be an effective means to enhance cardiac repair

Genetic mutation found to improve cognitive flexibility in mice

Heart and kidney patients should keep taking their medicines during COVID-19 pandemic

Researchers enlist the help of citizen scientists to design new drugs against coronavirus

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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