Respiratory News and Research

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Non-injectable vaccine may provide long-term protection against deadly Ebola virus

A potentially breathable, respiratory vaccine in development has been shown to provide long-term protection for non-human primates against the deadly Ebola virus, as reported this week in the online edition of the journal Molecular Pharmaceutics.

5 Nov 2014

Study: Tonsil removal for children with sleep apnea decreases asthma severity

Surgical removal of the tonsils and adenoids in children suffering from sleep apnea is associated with decreased asthma severity, according to the first large study of the connection, published in the journal PLOS Medicine.

4 Nov 2014

AstraZeneca, Pharmacyclics partner to evaluate efficacy of IMBRUVICA for solid tumors

AstraZeneca and Pharmacyclics, Inc. today announced that they have entered into a clinical trial collaboration to evaluate a novel combination therapy targeting solid tumors.

4 Nov 2014

New policy targeting hospital readmissions for COPD may hurt vulnerable patients, say experts

Last week, the federal government revealed that it will fine more than 2,600 hospitals in the coming year, because too many Medicare patients treated at these hospitals are ending up back in the hospital within 30 days of going home. Two new conditions have been added in this round of penalties: elective hip and knee replacement and chronic lung disease.

3 Nov 2014

FDA approves Fluzone High-Dose vaccine sBLA to include efficacy data in Prescribing Information

Sanofi Pasteur, the vaccines division of Sanofi, today announced that the U.S. Food and Drug Administration has approved the supplemental biologics license application (sBLA) for Fluzone High-Dose (Influenza Vaccine) to include efficacy data in the Prescribing Information.

3 Nov 2014

Epicure project: an interview with Frédéric Cren

Epicure is a project led by Inventiva and Institut Curie that aims to deliver pre-clinical candidates on two novel epigenetic targets that have been selected due to their potential to activate immune responses against cancer cells. In addition one of these two targets has potential in respiratory indications such as asthma or COPD.

3 Nov 2014

Study compares five-year DFS and OS rates for patients with AIS and MIA

Lung cancer patients with minimally invasive adenocarcinoma (MIA) have similar, positive five-year disease-free survival (DFS) and overall survival (OS) rates as patients with adenocarcinoma in-situ (AIS), according to research presented today at the 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology.

31 Oct 2014

LAMA/LABA combination better than monotherapy for severe COPD

Combination treatment with umeclidinium bromide and vilanterol offers clinically meaningful improvements over tiotropium monotherapy for patients with moderate-to-very severe chronic obstructive pulmonary disease, study data show.

31 Oct 2014

Study estimates Medicare costs of lung cancer diagnostic workup in patients

Biopsies were found to be the most costly tool prescribed in lung cancer diagnosis, according to research presented today at the 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology.

31 Oct 2014

WUSM researchers sequence genome of enterovirus D68 samples from patients

Researchers at Washington University School of Medicine in St. Louis have sequenced the genome of enterovirus D68 sampled from patients treated at St. Louis Children's Hospital. Nationwide, the virus has spread rapidly in recent months and caused severe respiratory illness in young children, with some patients requiring hospitalization.

30 Oct 2014

Drug-loaded plaster delivers active agent to premature babies via membrane

The development of minimally and even non-invasive technologies is increasing in the medical field. It is now possible, for instance, to carry out a range of operative procedures using keyhole surgery with minimal use of the scalpel, leaving only tiny scars as a result. Similar opportunities are now becoming available when providing doses of active agents to patients – instead of using injections or probes to deliver drugs, it will in future be possible to supply them via a plaster which continuously, gently and painlessly delivers the required dosage through the skin.

30 Oct 2014

Pulmocide uses INTEGRA's VIAFLO Assist pipetting assistant to improve screening of novel compounds

INTEGRA reports on how respiratory drug discovery and development specialists - Pulmocide Ltd. (London, UK) are using a VIAFLO Assist pipetting assistant to enhance the productivity and reproducibility of their screening of novel compounds in a range of biological assays.

From INTEGRA Biosciences 28 Oct 2014

Study shows that obese children may mistake asthma symptoms, overuse rescue medications

New research shows obese children with asthma may mistake symptoms of breathlessness for loss of asthma control leading to high and unnecessary use of rescue medications. The study was published online in the Journal of Allergy and Clinical Immunology, the official scientific journal of the American Association of Allergy, Asthma and Immunology.

27 Oct 2014

Researchers to explore new treatment strategies using blood plasma from Ebola survivors

The University of Liverpool is part of an international research team that will assess whether the blood or plasma of Ebola survivors can be used to treat Ebola patients in West Africa.

27 Oct 2014

Enhanced dental care reduces respiratory tract infection risk in ICU patients

New research shows vulnerable patients in the Intensive Care Unit (ICU) who received enhanced oral care from a dentist were at significantly less risk for developing a lower respiratory tract infection (LRTI), like ventilator-associated pneumonia, during their stay.

25 Oct 2014

Aseptika selected for Discovery Start-Ups 2014 award

Aseptika Limited was selected as one of five winners out of the eighteen strong field of UK start-up companies pitching for the winning prizes at the Discovery Start-Ups 2014 event held on Wednesday, 22nd October at Deloitte’s in London.

24 Oct 2014

Scientists use innovative exome sequencing strategy to identify new gene associated with ALS

Using an innovative exome sequencing strategy, a team of international scientists led by John Landers, PhD, at the University of Massachusetts Medical School has shown that TUBA4A, the gene encoding the Tubulin Alpha 4A protein, is associated with familial amyotrophic lateral sclerosis (ALS), a fatal neurological disorder also known as Lou Gehrig's Disease.

23 Oct 2014

Vascular receptor autoantibodies implicated in SSc-PAH

medwireNews: Autoantibodies to endothelin receptor type A and angiotensin receptor type-1 predict the development of, and mortality from, systemic sclerosis-associated pulmonary arterial hypertension, research suggests.

22 Oct 2014

Innovative treatment option for children with plastic bronchitis

A case study published recently in the journal Pediatrics describes an innovative, minimally invasive procedure that treated plastic bronchitis, a potentially life-threatening disease, in a six-year-old boy with a heart condition. Using new lymphatic imaging tools and catheterization techniques, physician-researchers eliminated bronchial casts, which are an accumulation of lymphatic material that clogged the child's airway.

22 Oct 2014

Janssen announces submission of IMBRUVICA sNDA to FDA for WM treatment

Janssen Research & Development, LLC today announced the submission of a supplemental New Drug Application (sNDA) for IMBRUVICA (ibrutinib) to the U.S. Food and Drug Administration by its strategic partner Pharmacyclics, Inc.

20 Oct 2014

Respiratory News and Research

Non-injectable vaccine may provide long-term protection against deadly Ebola virus

Study: Tonsil removal for children with sleep apnea decreases asthma severity

AstraZeneca, Pharmacyclics partner to evaluate efficacy of IMBRUVICA for solid tumors

New policy targeting hospital readmissions for COPD may hurt vulnerable patients, say experts

FDA approves Fluzone High-Dose vaccine sBLA to include efficacy data in Prescribing Information

Epicure project: an interview with Frédéric Cren

Study compares five-year DFS and OS rates for patients with AIS and MIA

LAMA/LABA combination better than monotherapy for severe COPD

Study estimates Medicare costs of lung cancer diagnostic workup in patients

WUSM researchers sequence genome of enterovirus D68 samples from patients

Drug-loaded plaster delivers active agent to premature babies via membrane

Pulmocide uses INTEGRA's VIAFLO Assist pipetting assistant to improve screening of novel compounds

Study shows that obese children may mistake asthma symptoms, overuse rescue medications

Researchers to explore new treatment strategies using blood plasma from Ebola survivors

Enhanced dental care reduces respiratory tract infection risk in ICU patients

Aseptika selected for Discovery Start-Ups 2014 award

Scientists use innovative exome sequencing strategy to identify new gene associated with ALS

Vascular receptor autoantibodies implicated in SSc-PAH

Innovative treatment option for children with plastic bronchitis

Janssen announces submission of IMBRUVICA sNDA to FDA for WM treatment

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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