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Alpaca nanobodies effective against South African SARS-CoV-2 variant

Researchers in South Africa and the UK have identified alpaca-derived nanoantibodies that potently neutralize variants of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

13 Apr 2021

Syphilis cases in California drive a record-setting year for STDs nationwide

In certain circles of San Francisco, a case of syphilis can be as common and casual as the flu, to the point where Billy Lemon can't even remember how many times he's had it.

13 Apr 2021

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

A new test that measures the quantity and quality of inactive HIV viruses in the genes of people living with HIV may eventually give researchers a better idea of what drugs work best at curing the disease.

12 Apr 2021

Novel PF74 molecule effectively targets HIV capsid protein

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication.

9 Apr 2021

Effective response to HIV and COVID-19 pandemics requires accelerated research

The COVID-19 pandemic is affecting people with or at risk for HIV both indirectly, by interfering with HIV treatment and prevention services, and directly, by threatening individual health.

9 Apr 2021

Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research last week launched a Phase 2 clinical trial in Thailand to evaluate an interleukin-15 (IL-15) superagonist, ImmunityBio's Anktiva (also called N-803), administered during acute HIV infection as an experimental therapy to target establishment of the HIV reservoir at a very early stage.

8 Apr 2021

IRB Barcelona researchers find the Achilles heel of some lung tumors

In cancer, personalized medicine takes advantage of the unique genetic changes in an individual tumor to find its vulnerabilities and fight it.

8 Apr 2021

Eliminating racism and anti-LGBTQ policies can improve the health of black sexual minority men

Eliminating racist and anti-LGBTQ policies is essential to improving the health of Black gay, bisexual and other sexual minority men, according to a Rutgers-led research team.

8 Apr 2021

The interaction between blood clotting and SARS-CoV-2 infection

Coagulopathy - a condition in which the blood's ability to clot is impaired, is recognized as a significant aspect of morbidity in COVID-19 patients. In a recent study, Prof Lewis Cantley and a team of researchers explored the role of coagulation factors in the SARS-CoV-2 infection. Their recent study is posted on the bioRxiv server.

7 Apr 2021

The GovLab, AFD and Expertise France select 7 projects to address COVID-19 challenges in Africa

Out of a field of over 80 proposals by organizations in Africa -- many working in collaboration -- The Governance Lab (GovLab) at the NYU Tandon School of Engineering, L'Agence Francaise de Developpement (AFD), and Expertise France chose seven projects to receive the #Data4COVID19 Africa Challenge.

7 Apr 2021

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

A fascinating new preprint research paper posted to the bioRxiv* server discusses impressively high neutralizing responses elicited with a single dose of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine formulation, which could help turn the tide of the current pandemic if validated.

6 Apr 2021

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

While the U.S. has begun to vaccinate millions of Americans each day, COVID-19 vaccine supplies around the world remain scarce.

5 Apr 2021

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

The Foundation for Innovative New Diagnostics (FIND) announced today the launch of a request for proposals (RFP) to accelerate the development, manufacturing, and market availability of accurate, affordable, quality-assured and easy-to-use SARS-CoV-2 self-tests for use in low- and middle-income countries (LMICs).

5 Apr 2021

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.

3 Apr 2021

Africa's health systems are failing to meet the needs of vulnerable groups

Less than half the population of Africa are not receiving the health services they need, with vulnerable groups including gay and disabled people left behind, says a report.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

30 Mar 2021

Arginine methylation important in SARS-CoV-2 viral replication

Researchers show that methylation of arginine in the virus nucleocapsid protein controls the protein's functions and plays a role in the life cycle of the SARS-CoV-2 virus.

29 Mar 2021

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2 - the virus that causes COVID-19 – and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects. In their experiments in fruit flies and human cell lines, the team discovered the cell process that the virus hijacks, illuminating new potential candidate drugs that could be tested for treating severe COVID-19 disease patients.

29 Mar 2021

GlyNAC could improve many age-associated defects in older humans

A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC - a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione - could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging.

29 Mar 2021

HIV 1 News and Research

Alpaca nanobodies effective against South African SARS-CoV-2 variant

Syphilis cases in California drive a record-setting year for STDs nationwide

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

Novel PF74 molecule effectively targets HIV capsid protein

Effective response to HIV and COVID-19 pandemics requires accelerated research

Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

IRB Barcelona researchers find the Achilles heel of some lung tumors

Eliminating racism and anti-LGBTQ policies can improve the health of black sexual minority men

The interaction between blood clotting and SARS-CoV-2 infection

The GovLab, AFD and Expertise France select 7 projects to address COVID-19 challenges in Africa

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

Africa's health systems are failing to meet the needs of vulnerable groups

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

Arginine methylation important in SARS-CoV-2 viral replication

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

GlyNAC could improve many age-associated defects in older humans

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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