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Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers evaluated the comparative pathogenicity of SARS-CoV-2 Omicron sub-variants BA.1, BA.2, and BA.5, in vitro and in vivo.

9 Aug 2022

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Scientists review current literature associated with the role of the gut-brain axis in AD pathogenesis.

9 Aug 2022

Researchers unravel a novel molecular target of eicosapentaenoic acid

Eicosapentaenoic acid (EPA) is an essential nutrient belonging to the omega-3 group of polyunsaturated fatty acids (PUFAs). As the human body cannot synthesize PUFAs, dietary supplements containing EPA are required for normal physiological functions. Found abundantly in natural sources like fish, hemp oil, and linseed oil, EPA is known to exhibit anti-inflammatory, neuroprotective, and cardiovascular protective activities.

9 Aug 2022

New insights into the understanding of how ApoE variants contribute to Tau pathology in Alzheimer’s disease

Researchers examined the impact of tau neuropathology of APOE3 Christchurch (APOE3ch) homozygote against Alzheimer’s disease.

8 Aug 2022

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers demonstrated that vaccine frameworks containing deoxyribonucleic acid (DNA) origami possessing SARS-CoV-2 receptor-binding domain induce strong protective immunity.

8 Aug 2022

Researchers create a physical wiring diagram of the human immune system

In a new study, researchers systematically mapped the surface proteins on human leukocytes to examine interactions between their cell-surface proteomes and develop a physical wiring diagram encapsulating the diversity of surface protein architectures found across all major subsets of leukocytes.

8 Aug 2022

New dual-plasmid editing system for DNA-based information rewriting in vivo

DNA-based information is a new interdisciplinary field linking information technology and biotechnology.

5 Aug 2022

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Researchers develop a genetically modified airway organoid system, which overcomes challenges related to natural variations in ACE2 levels

4 Aug 2022

New hydrogel treatment disrupts cavity-forming biofilms and whitens teeth

The first thing people notice when they meet you is your smile. To be more confident when giving wide-mouthed, eye-crinkling smiles, people want healthy, pearly white teeth.

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN Bio 3 Aug 2022

Hemopurifier containing Galanthus nivalis resin removes SARS-CoV-2 variants

Scientists hypothesize that the GNA affinity resin would remain effective against SARS-CoV-2 variants.

2 Aug 2022

Miniature surgical robot gets ready for a 2024 test mission aboard the ISS

A miniaturized robot invented by Nebraska’s Shane Farritor is on scheduled to blast off into space to showcase its skills.

2 Aug 2022

The efficacy of honokiol in inhibiting SARS-CoV-2 replication in cell culture

Researchers evaluated the efficacy of honokiol in inhibiting SARS-CoV-2 replication in cell cultures.

2 Aug 2022

How does COVID-19 affect sexual and bladder functions in men?

Researchers discuss the impact of COVID-19 on the urogenital health of males.

1 Aug 2022

Study: SARS-CoV-2 variants of concern and biological sex of patients affect molnupiravir efficacy

SARS-CoV-2 variants of concern and the biological sex of patients affect the efficacy of molnupiravir, the first orally available drug approved for outpatient use against COVID-19, according to a new study led by researchers in the Center for Translational Antiviral Research in the Institute for Biomedical Sciences at Georgia State University.

1 Aug 2022

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Researchers assessed the potential of nanosponges against SARS-CoV-2.

1 Aug 2022

Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic

Researchers assessed the pre-existing cross-protective immune responses against SARS-CoV-2 nucleocapsid protein and spike protein before the COVID-19 pandemic in individuals residing in North and South America, Europe and Africa in vitro and in vivo.

1 Aug 2022

Nanoparticles' toxic effects on macrophages

Researchers summarize the toxic effects of nanoparticles on macrophages in vitro.

31 Jul 2022

Is cannabidiol effective against COVID-19?

A new study discusses the utility of CBD in treating the inflammatory symptoms of COVID-19

31 Jul 2022

Researchers use a tumor organoid system to examine bacterial effects on immunotherapy

Wake Forest Institute for Regenerative Medicine researchers are using a tumor organoid system to examine the effects of metabolites secreted by bacteria on a specialized immunotherapy – immune checkpoint blockage, a promising cancer treatment development – to determine why some patients don't respond or develop a resistance to the treatment over time.

29 Jul 2022

in vivo News and Research

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Researchers unravel a novel molecular target of eicosapentaenoic acid

New insights into the understanding of how ApoE variants contribute to Tau pathology in Alzheimer’s disease

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers create a physical wiring diagram of the human immune system

New dual-plasmid editing system for DNA-based information rewriting in vivo

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

New hydrogel treatment disrupts cavity-forming biofilms and whitens teeth

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Hemopurifier containing Galanthus nivalis resin removes SARS-CoV-2 variants

Miniature surgical robot gets ready for a 2024 test mission aboard the ISS

The efficacy of honokiol in inhibiting SARS-CoV-2 replication in cell culture

How does COVID-19 affect sexual and bladder functions in men?

Study: SARS-CoV-2 variants of concern and biological sex of patients affect molnupiravir efficacy

The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2

Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic

Nanoparticles' toxic effects on macrophages

Is cannabidiol effective against COVID-19?

Researchers use a tumor organoid system to examine bacterial effects on immunotherapy

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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