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FDA accepts Salix and Progenics' sNDA filing for RELISTOR to treat opioid-induced constipation

Progenics Pharmaceuticals, Inc. and Salix Pharmaceuticals, Ltd. today announced that the U.S. Food and Drug Administration (FDA) has accepted for filing a supplemental New Drug Application (sNDA) for RELISTOR Subcutaneous Injection to treat opioid-induced constipation (OIC) in patients with non-cancer pain.

30 Aug 2011

Balloon pump use prior to PCI does not reduce infarct size in STEMI patients without shock

Intra-aortic balloon pump counterpulsation prior to PCI in patients with ST segment elevation MI does not reduce infarct size as measured by MRI, according to results from the Counterpulsation Reduces Infarct Size Acute Myocardial Infarction (CRISP AMI) trial.

30 Aug 2011

Xience V stent performs well in patients with primary PCI for ST elevation myocardial infarction

The second generation drug-eluting stent Xience V performs well in patients having primary PCI for ST elevation myocardial infarction, and has a better safety profile than that of bare metal stents, according to results of the EXAMINATION trial.

30 Aug 2011

Results of darexaban phase II trial in recent acute coronary syndrome presented at ESC Congress

A phase II dose-finding study has found that the new oral Factor Xa inhibitor darexaban was associated with a two to four-fold increase in bleeding when added to dual antiplatelet therapy in patients following an acute coronary syndrome.

30 Aug 2011

Remote follow-up of ICD patients seems to be a safe alternative to conventional in-office methods

Results from the EVATEL trial are the first in Europe to demonstrate potential safety and efficacy benefits from the remote follow-up of ICD patients.

30 Aug 2011

Researchers investigate potential of vesicular stomatitis virus against soft tissue sarcomas

Researchers from Yale University are looking to a virus from the same family as the rabies virus to fight a form of cancer primarily found in children and young adults.

30 Aug 2011

Magnetic resonance imaging may predict survival in patients with advanced rectal cancer

A new study has shown that magnetic resonance imaging (MRI) used to evaluate responses to pre-surgery (neo-adjuvant) chemotherapy or radiation may predict survival among patients with advanced rectal cancer.

30 Aug 2011

U-M's minimally invasive revascularization procedure can treat peripheral arterial disease

Henry Gibbs, 58, is a ballroom dance instructor, but he was forced to hang up his dancing shoes when a circulation condition, common among older adults, caused severe leg pain and cramping.

29 Aug 2011

Health Canada approves Bayer's STAXYN for treatment of erectile dysfunction

Today, Bayer Inc. announced the Health Canada approval of STAXYN, the first orally disintegrating tablet for the treatment of erectile dysfunction (ED) that lasts up to eight hours.

29 Aug 2011

Philips to launch first sleep apnea mobile app at ESC 2011 congress

Royal Philips Electronics will provide clinicians from across the globe with a glimpse of future innovations designed to advance cardiac care, including the current management of cardiovascular disease (CVD) and associated cardiac conditions, during the 2011 Congress of the European Society of Cardiology (ESC), which opens today in Paris.

From Philips Healthcare 29 Aug 2011

Boehringer Ingelheim initiates two afatinib phase II studies in HER2-positive breast cancer

Boehringer Ingelheim today announced the initiation of two phase II studies, 1200.89 and LUX-Breast 2, evaluating afatinib in patients with metastatic breast cancer, who have an overexpression of the erbB2 (HER2) protein, so called HER2-positive patients. Afatinib is an irreversible ErbB Family Blocker, which binds to all erbB-family kinases including erbB2.

29 Aug 2011

Dabigatran etexilate superior to warfarin for stroke prevention in AF patients

New data from two RE-LY trial sub-group analyses show that dabigatran etexilate provides consistent benefits in stroke in atrial fibrillation (AF) compared to well-controlled warfarin, irrespective of whether patients use antiplatelet or other concomitant therapies, such as the anti-arrhythmics amiodarone or verapamil.

29 Aug 2011

Everolimus-eluting stent and SES are equally effective for PCI patients

The second generation drug-eluting stent, everolimus-eluting stent (EES), has consistently demonstrated superior clinical outcomes in randomised controlled trials over the first generation drug-eluting stent, paclitaxel-eluting stent.

29 Aug 2011

EAS/ESC develops new dyslipidaemias guidelines

Clinicians should aim for comprehensive lipid control using lifestyle as a first step and tailoring treatment to patients. Lifestyle interventions, including stopping smoking, improving diet, exercising sufficiently and moderate alcohol consumption, should be the crucial first step for managing lipids in all patients.

29 Aug 2011

Sutureless method for reconnecting blood vessels

Reconnecting severed blood vessels is mostly done the same way today - with sutures - as it was 100 years ago, when the French surgeon Alexis Carrel won a Nobel Prize for advancing the technique.

29 Aug 2011

AAO-HNSF's 2011 Annual Meeting & OTO EXPO to convene in San Francisco

The 2011 Annual Meeting & OTO EXPO of the American Academy of Otolaryngology - Head and Neck Surgery Foundation (AAO-HNSF), the largest meeting of ear, nose, and throat doctors in the world, will convene September 11-14, 2011, in San Francisco, CA.

29 Aug 2011

MitraClip treatment could benefit heart failure patients who are unresponsive to CRT

Results of an observational study presented at the European Society of Cardiology (ESC) meeting today in Paris demonstrate that the percutaneous catheter-based MitraClip treatment improves symptoms and promotes reverse left ventricular (LV) remodeling in patients with mitral regurgitation (MR), who do not respond to cardiac resynchronization therapy.

29 Aug 2011

Colchicine more effective than placebo for recurrent pericarditis

Colchicine, when given in addition to conventional therapy, was more effective than placebo in reducing the incidence of recurrence and the persistence of symptoms of pericarditis in a randomised controlled trial.

29 Aug 2011

Pfizer receives FDA approval for XALKORI capsules to treat ALK-positive NSCLC

Pfizer Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved XALKORI (crizotinib) capsules, the first-ever therapy targeting anaplastic lymphoma kinase (ALK), for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) that is ALK-positive as detected by an FDA-approved test.

29 Aug 2011

Severe combined immunodeficiency treated successfully with gene therapy

Gene therapy can offer a cure for a rare condition that causes children’s immune systems to fail. In this rare condition, known as Severe Combined Immunodeficiency (SCID), inherited genetic mutations mean that babies are unable to fight off infection, severely limiting their chances of surviving more than a few years. Severe combined immunodeficiency (SCID) is a rare genetic disorder estimated to affect between 1 in 200,000 and 1 in 1,000,000 live births

26 Aug 2011

Efficacy News and Research

FDA accepts Salix and Progenics' sNDA filing for RELISTOR to treat opioid-induced constipation

Balloon pump use prior to PCI does not reduce infarct size in STEMI patients without shock

Xience V stent performs well in patients with primary PCI for ST elevation myocardial infarction

Results of darexaban phase II trial in recent acute coronary syndrome presented at ESC Congress

Remote follow-up of ICD patients seems to be a safe alternative to conventional in-office methods

Researchers investigate potential of vesicular stomatitis virus against soft tissue sarcomas

Magnetic resonance imaging may predict survival in patients with advanced rectal cancer

U-M's minimally invasive revascularization procedure can treat peripheral arterial disease

Health Canada approves Bayer's STAXYN for treatment of erectile dysfunction

Philips to launch first sleep apnea mobile app at ESC 2011 congress

Boehringer Ingelheim initiates two afatinib phase II studies in HER2-positive breast cancer

Dabigatran etexilate superior to warfarin for stroke prevention in AF patients

Everolimus-eluting stent and SES are equally effective for PCI patients

EAS/ESC develops new dyslipidaemias guidelines

Sutureless method for reconnecting blood vessels

AAO-HNSF's 2011 Annual Meeting & OTO EXPO to convene in San Francisco

MitraClip treatment could benefit heart failure patients who are unresponsive to CRT

Colchicine more effective than placebo for recurrent pericarditis

Pfizer receives FDA approval for XALKORI capsules to treat ALK-positive NSCLC

Severe combined immunodeficiency treated successfully with gene therapy

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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