Protein C News and Research

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New form of gene editing slows ALS progression in mice

With a new CRISPR gene-editing methodology, scientists from the University of Illinois at Urbana-Champaign inactivated one of the genes responsible for an inherited form of amyotrophic lateral sclerosis - a debilitating and fatal neurological disease for which there is no cure.

26 Feb 2020

Biomarkers in blood samples can predict clinical response to immunotherapy in metastatic NSCLC

Non-small cell lung cancer patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations.

26 Feb 2020

Blue light illuminates key ALS pathologies in zebrafish

A joint research group in Japan has succeeded in reproducing key ALS symptoms in a small tropical fish by remote controlling a disease-associated protein molecule using light illumination.

26 Feb 2020

Breakthrough research may lead to improved therapeutic options for people with asthma

Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma.

26 Feb 2020

Large non-protein coding gene regulates process vital to placental implantation in early pregnancy

Abnormal formation and growth of the placenta is considered an underlying cause of various pregnancy complications such as miscarriages, preeclampsia and fetal growth restriction.

25 Feb 2020

Researchers reveal new details about how joint inflammation evolves in rheumatoid arthritis

Walter and Eliza Hall Institute researchers have revealed new details about how joint inflammation evolves in rheumatoid arthritis, and the cells that prolong the inflammatory attack.

25 Feb 2020

Prolonged exposure to a pair of antioxidant proteins may fuel liver enlargement

All life is challenged by oxidants -- reactive molecules or compounds that remove electrons from other molecules -- often with adverse effect, commonly referred to as oxidative stress.

25 Feb 2020

Researchers uncover how cancer cells override environmental cues to consume energy

Using human lung cancer cells, UT Southwestern researchers have uncovered how cells in general modulate their energy consumption based on their surroundings and, furthermore, how cancer cells override those cues to maximize energy use.

24 Feb 2020

A promising new oral therapy to speed up healing of broken bones

People with diabetes are at a higher risk of fracturing a bone than the general population. And if they do break one it also takes longer than normal to heal.

24 Feb 2020

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy, an as-yet-uncured disease that results in devastating muscle weakening and loss.

24 Feb 2020

Clemson researchers discover protein function in parasites which afflict millions with diseases

In the quest to develop more effective treatments for parasitic diseases like African sleeping sickness, Chagas disease and Leishmaniasis, scientists look for weaknesses in the organisms' molecular machinery. These weaknesses can then be targeted with drug therapies designed to kill the parasites.

24 Feb 2020

Cryo-electron microscopy reveals how transport protein works very efficiently

The structure of a transport complex used by bacteria to import aspartate has been mapped in unique detail by University of Groningen scientists.

24 Feb 2020

Guiding nanoparticles directly to the tumor cells

Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue. An interdisciplinary team of researchers at Helmholtz-Zentrum Dresden-Rossendorf and FU Berlin has made important progress in this area: the scientists have produced tiny nanoparticles that are designed to specifically target cancer cells.

24 Feb 2020

A highly conserved protein contributes to sensing mechanical pain, study shows

Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new analgesic drugs.

24 Feb 2020

Simple blood test could be used by GPs to aid in earlier brain tumor diagnosis

A new simple blood test for brain tumors that could be used by GPs in primary care is being developed thanks to funding of nearly £500,000 by Cancer Research UK.

24 Feb 2020

Supplementing diet with amino acid delays signs of ALS in animal study

The addition of dietary L-serine, a naturally occurring amino acid necessary for formation of proteins and nerve cells, delayed signs of amyotrophic lateral sclerosis in an animal study.

24 Feb 2020

Inflammation caused by radiation can promote survival of triple-negative breast cancer cells

While radiation is successfully used to treat breast cancer by killing cancer cells, inflammation caused as a side-effect of radiation can have a contrary effect by promoting the survival of triple-negative breast cancer cells, according to research published online in the International Journal of Radiation Biology by Jennifer Sims-Mourtada, Ph.D., director of Translational Breast Cancer Research at ChristianaCare's Helen F. Graham Cancer Center & Research Institute.

24 Feb 2020

Researchers explore whether plaque identifying toothpaste could prevent heart attack, stroke

For decades, researchers have suggested a link between oral health and inflammatory diseases affecting the entire body -- in particular, heart attacks and strokes.

24 Feb 2020

Breast cancer cells hibernate in the lung before forming secondary tumors

Healthy lung cells support the survival of breast cancer cells, allowing them to hibernate in the lung before forming secondary tumors, according to new research from the Crick.

24 Feb 2020

Researchers discover glial cells that control stress response, extend lifespan in worms

While many of us worry about proteins aggregating in our brains as we age and potentially causing Alzheimer's disease or other types of neurodegeneration, we may not realize that some of the same proteins are aggregating in our muscles, setting us up for muscle atrophy in old age.

23 Feb 2020

Protein C News and Research

New form of gene editing slows ALS progression in mice

Biomarkers in blood samples can predict clinical response to immunotherapy in metastatic NSCLC

Blue light illuminates key ALS pathologies in zebrafish

Breakthrough research may lead to improved therapeutic options for people with asthma

Large non-protein coding gene regulates process vital to placental implantation in early pregnancy

Researchers reveal new details about how joint inflammation evolves in rheumatoid arthritis

Prolonged exposure to a pair of antioxidant proteins may fuel liver enlargement

Researchers uncover how cancer cells override environmental cues to consume energy

A promising new oral therapy to speed up healing of broken bones

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Clemson researchers discover protein function in parasites which afflict millions with diseases

Cryo-electron microscopy reveals how transport protein works very efficiently

Guiding nanoparticles directly to the tumor cells

A highly conserved protein contributes to sensing mechanical pain, study shows

Simple blood test could be used by GPs to aid in earlier brain tumor diagnosis

Supplementing diet with amino acid delays signs of ALS in animal study

Inflammation caused by radiation can promote survival of triple-negative breast cancer cells

Researchers explore whether plaque identifying toothpaste could prevent heart attack, stroke

Breast cancer cells hibernate in the lung before forming secondary tumors

Researchers discover glial cells that control stress response, extend lifespan in worms

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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