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Early use of heart failure drugs slows cardiac damage in boys, young men with DMD

Early use of available heart failure drugs slows the progressive decline in heart function before symptoms are apparent in boys and young men with Duchenne muscular dystrophy (DMD), according to a new study published online by The Lancet Neurology.

30 Dec 2014

Kinex Pharmaceuticals doses first patient with KX2-361 in ‘A Phase 1’ clinical trial

Kinex Pharmaceuticals announced today that the first patient has been dosed with KX2-361 at Roswell Park Cancer Institute.

25 Dec 2014

Penn researchers find effective way to inhibit inflammatory response during kidney dialysis

Frequent kidney dialysis is essential for the approximately 350,000 end-stage renal disease (ESRD) patients in the United States. But it can also cause systemic inflammation, leading to complications such as cardiovascular disease and anemia, and patients who rely on the therapy have a five-year survival rate of only 35 percent. Such inflammation can be triggered when the complement cascade, part of the body's innate immune system, is inadvertently activated by modern polymer-based dialysis blood filters.

14 Dec 2014

Scientists to explore biology of human asthma by using slime mould

Scientists from Royal Holloway, University of London, will research the biology of human asthma by using a slime mould, an organism which has no lungs but could hold the key to new treatments.

12 Dec 2014

UB researchers explore link between behavioral symptoms and chronic traumatic encephalopathy

Aggression, violence, depression, suicide. Media reports routinely link these behavioral symptoms with chronic traumatic encephalopathy (CTE), the neurodegenerative brain disease, in former football players.

5 Dec 2014

Study: PET scanning strategy could help predict effectiveness of TB drugs

Sophisticated lung imaging can show whether or not a treatment drug is able to clear tuberculosis (TB) lung infection in human and macaque studies, according to researchers at the University of Pittsburgh School of Medicine and their international collaborators.

5 Dec 2014

UAB research suggests potential therapeutic target for patients with frontotemporal dementia

Drugs that boost the function of a specific type of neurotransmitter receptor may provide benefit to patients with the second most common type of dementia, according to research by scientists at the University of Alabama at Birmingham published today in the Journal of Neuroscience.

4 Dec 2014

Study reports effective treatment approach to inhibit herpes virus infection

A multi-institutional study reports an effective treatment approach to inhibit and keep latent viruses like herpes simplex from reactivating and causing disease. The work, whose lead author is the late James Hill, PhD, LSU Health New Orleans Professor and Director of Pharmacology and Infectious Disease at the LSU Eye Center, is published in the December 3, 2014, issue of Science Translational Medicine.

4 Dec 2014

Study provides proof of concept for developing antibodies against human pathogens

Scientists investigating the potentially deadly hantavirus have used a novel approach to developing protective antibodies against it. Their work, published in today's online edition of Science Translational Medicine, provides proof of concept for producing antibodies against a broad range of human pathogens.

28 Nov 2014

Leeds researchers identify gene associated with autism symptoms

Researchers at the University of Leeds have shed light on a gene mutation linked to autistic traits. The team already knew that some people with autism were deficient in a gene called neurexin-II.

26 Nov 2014

Research sheds light on gene mutation linked to autistic traits

Researchers at the University of Leeds have shed light on a gene mutation linked to autistic traits.

25 Nov 2014

Abnormal connections between neurons cause motor coordination issues in autism

Abnormal connections between neurons are the likely cause of motor coordination issues seen in autism spectrum disorder. Using a mouse model of autism, scientists from the University of Chicago identified a malfunctioning neural circuit associated with reduced capacity for motor learning. This appears to arise from an inability to eliminate unneeded neural connections in the brain.

24 Nov 2014

Surgical membrane delivers healing action of vitamin A

When blood vessels are damaged through surgery, it can trigger an endless cycle of scarring and repair.

21 Nov 2014

New treatment for Marfan syndrome works as well as beta blockers

A new treatment for Marfan syndrome, a rare genetic disease that can lead to heart problems, works as well as the currently recommended medical therapy, beta blockers, according to an article in the New England Journal of Medicine.

21 Nov 2014

Infections due to Staphylococcus aureus bacterium aggravate neurodermatitis

Because the skin and its function as a barrier are severely compromised in neurodermatitis patients, a large number of bacterial species are able to multiply - including the bacterium Staphylococcus aureus.

21 Nov 2014

TSRI study examines body’s own response against chronic protein misfolding

“Protein misfolding” diseases such as cystic fibrosis and Alzheimer’s may be seriously exacerbated by the body’s own response against that misfolding, according to a new study led by scientists at The Scripps Research Institute.

20 Nov 2014

Chemotherapy drug combined with cancer-killing virus may treat recurrent ovarian cancer

In six out of 10 cases, ovarian cancer is diagnosed when the disease is advanced and five-year survival is only 27 percent.

14 Nov 2014

U of G research may lead to novel treatment approaches for late-stage ovarian cancer

In a potential breakthrough against ovarian cancer, University of Guelph researchers have discovered how to both shrink tumours and improve drug delivery, allowing for lower doses of chemotherapy and reducing side effects.

13 Nov 2014

Scientists receive NARSAD Distinguished Investigator Grants for mental health research

The Brain & Behavior Research Foundation today announced the award of NARSAD Distinguished Investigator Grants valued at $1.5 million to 15 scientists, who are full professors or the equivalent, conducting innovative projects in diverse areas of neurobiological and behavioral research.

13 Nov 2014

Endothelin gene expression linked to vision loss in premature babies

A gene known to play a major role in constricting blood vessels also appears to be a major player in the aberrant blood vessel growth that can destroy the vision of premature babies.

11 Nov 2014

Animal Model News and Research

Early use of heart failure drugs slows cardiac damage in boys, young men with DMD

Kinex Pharmaceuticals doses first patient with KX2-361 in ‘A Phase 1’ clinical trial

Penn researchers find effective way to inhibit inflammatory response during kidney dialysis

Scientists to explore biology of human asthma by using slime mould

UB researchers explore link between behavioral symptoms and chronic traumatic encephalopathy

Study: PET scanning strategy could help predict effectiveness of TB drugs

UAB research suggests potential therapeutic target for patients with frontotemporal dementia

Study reports effective treatment approach to inhibit herpes virus infection

Study provides proof of concept for developing antibodies against human pathogens

Leeds researchers identify gene associated with autism symptoms

Research sheds light on gene mutation linked to autistic traits

Abnormal connections between neurons cause motor coordination issues in autism

Surgical membrane delivers healing action of vitamin A

New treatment for Marfan syndrome works as well as beta blockers

Infections due to Staphylococcus aureus bacterium aggravate neurodermatitis

TSRI study examines body’s own response against chronic protein misfolding

Chemotherapy drug combined with cancer-killing virus may treat recurrent ovarian cancer

U of G research may lead to novel treatment approaches for late-stage ovarian cancer

Scientists receive NARSAD Distinguished Investigator Grants for mental health research

Endothelin gene expression linked to vision loss in premature babies

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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