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Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

29 Mar 2021

Researchers identify new drug candidates for treating patients with severe COVID-19

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2--the virus that causes COVID-19 - and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects.

27 Mar 2021

‘Incredibly concerning’ lawsuit threatens no-charge preventive care for millions

With a challenge to the Affordable Care Act still pending at the Supreme Court, conservatives are continuing to launch legal attacks on the law, including a case in which a Texas federal judge seems open to ending the requirement that most Americans must receive preventive services like mammograms free of charge.

26 Mar 2021

Genomic sieve analysis can inform the development of SARS-Cov-2 vaccine

As concern has grown over COVID-19 variants and their implications for how well COVID-19 vaccines will protect against the virus, researchers have proposed a method to examine instances of SARS-COV-2 infections in people who have received a COVID-19 vaccine.

26 Mar 2021

New screening method detects cancer biomarkers more effectively

Early screening can mean the difference between life and death in a cancer and disease diagnosis. That's why University of Central Florida researchers are working to develop a new screening technique that's more than 300 times as effective at detecting a biomarker for diseases like cancer than current methods.

26 Mar 2021

First-of-its-kind project to disseminate bundled interventions for Black women with HIV

The University of Massachusetts Lowell, in collaboration with AIDS United, and the Center for Innovation in Social Work & Health at Boston University's School of Social Work (BUSSW), have been tapped to lead a national, first-of-its-kind project to evaluate and disseminate bundled evidence-informed and trauma-informed interventions for Black women with HIV.

25 Mar 2021

High throughput screening for COVID-19 with the VOYAGER pipette

The COVID-19 pandemic has slowed down research in many scientific areas, but for the Jain Lab in the Department of Chemical Engineering at the University of Florida, the pandemic has created an exciting opportunity to repurpose their work.

From INTEGRA Biosciences 24 Mar 2021

Researchers identify chemicals that keep HIV virus in dormant state

When the human immunodeficiency virus infects cells, it can either exploit the cells to start making more copies of itself or remain dormant--a phenomenon called latency.

24 Mar 2021

COVID-19 sets back TB progress by a decade, shows WHO report

More than half a million people may have died last year as a result of reductions in TB diagnosis and care, setting back progress towards ending the disease by a decade, the World Health Organization (WHO) estimates.

24 Mar 2021

New guidance can help identify communities at highest risk of tuberculosis

An estimated 1.4 million fewer people received care for tuberculosis (TB) in 2020 than in 2019, according to preliminary data compiled by the World Health Organization (WHO) from over 80 countries- a reduction of 21% from 2019.

24 Mar 2021

New guidelines outline key new actions to improve delivery of HIV testing, treatment and care

These guidelines provide new and updated recommendations on the use of point-of-care testing in children under 18 months of age and point-of-care tests to monitor treatment in people living with HIV; the treatment monitoring algorithm; and timing of antiretroviral therapy (ART) among people living with HIV who are being treated for tuberculosis.

23 Mar 2021

SARS-CoV-2 infection is circadian

An international team of researchers has found that angiotensin-converting enzyme 2 (ACE2) levels in lung cells vary over the day, affecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The virus entry and replication in the lung cells also have a rhythmic cycle, suggesting circadian processes can affect the virus's life cycle.

22 Mar 2021

ChAdOx1 nCoV-19 offers less protection against South African SARS-CoV-2 variant

The results of a double-blind, randomized, multisite placebo-controlled trial that was conducted in South Africa show that Oxford’s ChAdOx1 nCoV-19 (AZD1222) vaccine has no efficacy against the B.1.351 variant in preventing mild-to-moderate coronavirus disease 2019 (COVID-19), and shows reduced neutralization properties of developed antibodies. The findings are published in the New England Journal of Medicine.

21 Mar 2021

Developing a COVID-19 vaccine using inactivated E. coli

A team of researchers inactivated whole-cell E.coli with a reduced genome and utilized this to express coronavirus-specific fusion peptides, demonstrating a potent anamnestic response.

19 Mar 2021

Researchers explore nanotechnology’s potential to deliver synergistic therapeutics for COVID-19

A team of scientists reviewed the nanoencapsulation approaches of synergistic compounds (Lectins, Caffeine, Cocoa, Flavonoids, Quercetin) and the role of nanotechnology in addressing the COVID-19 pandemic.

19 Mar 2021

Engineering immunogens to focus immune response to SARS-CoV-2

Researchers have designed constructs by adding more glycans and adding the receptor-binding motif from related sarbecoviruses to focus the immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding motif. Such immunogens could potentially also neutralize other variants and coronaviruses.

18 Mar 2021

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Metformin, a drug used to treat type-2 diabetes, could help reduce chronic inflammation in people living with HIV (PLWH) who are being treated with antiretroviral therapy (ART), according to researchers at the University of Montreal Hospital Research Centre.

18 Mar 2021

HIV 1 News and Research

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

Researchers identify new drug candidates for treating patients with severe COVID-19

‘Incredibly concerning’ lawsuit threatens no-charge preventive care for millions

Genomic sieve analysis can inform the development of SARS-Cov-2 vaccine

New screening method detects cancer biomarkers more effectively

First-of-its-kind project to disseminate bundled interventions for Black women with HIV

High throughput screening for COVID-19 with the VOYAGER pipette

Researchers identify chemicals that keep HIV virus in dormant state

COVID-19 sets back TB progress by a decade, shows WHO report

New guidance can help identify communities at highest risk of tuberculosis

New guidelines outline key new actions to improve delivery of HIV testing, treatment and care

SARS-CoV-2 infection is circadian

ChAdOx1 nCoV-19 offers less protection against South African SARS-CoV-2 variant

Developing a COVID-19 vaccine using inactivated E. coli

Researchers explore nanotechnology’s potential to deliver synergistic therapeutics for COVID-19

Engineering immunogens to focus immune response to SARS-CoV-2

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Undocumented pregnant women in Finland receive inadequate prenatal care, study shows

Coronaviruses may be vulnerable to ultrasound vibrations, study suggests

Abbott Pandemic Defence Coalition aims to identify new viral threats and take quick action

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How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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