Mutation News and Research

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Discovery of antibodies that may eliminate the need for COVID vaccines

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11 Sep 2022

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

9 Sep 2022

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers.

8 Sep 2022

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

Techniques used for SARS-CoV-2 detection in body fluids

In a recent review published in the journal Trends in Analytical Chemistry, researchers provided a comprehensive overview of the current techniques used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in bodily fluids.

7 Sep 2022

New method accurately analyzes genomics data in cancer archival biopsies

A new paper from University of Helsinki, published today on Nature Communications, suggests a method for accurately analyzing genomics data in cancer archival biopsies.

6 Sep 2022

Sensitivity of SARS-CoV-2 Omicron BA.2.75 to neutralization by monoclonal antibodies and sera

Researchers assessed the sensitivity of the SARS-CoV-2 Omicron subvariant BA.2.75 spike protein to neutralization by monoclonal antibodies and sera obtained from Swedish individuals.

5 Sep 2022

Bringing flexibility to Sanger sequencing and DNA-fragment analysis with the Spectrum Compact CE System

In this interview, News Med is talking to Gabriela Saldanha about DNA Fragmentation and Sanger Sequencing.

From Promega Corporation 5 Sep 2022

Study uncovers the evolutionary dynamics of SARS-CoV-2 at primary stage of massive vaccination

This study uncovers the evolutionary dynamics of SARS-CoV-2 and epidemiological characteristics of COVID-19 at the primary stage of massive vaccination

2 Sep 2022

What is currently known about immune responses to COVID-19 vaccines and cellular immune responses against SARS-CoV-2?

Researchers summarized existing data on the immunogenicity of COVID-19 vaccines and the humoral and cellular immune responses against SARS-CoV-2.

2 Sep 2022

The origins, breadth, and resolution of autoreactivity in severe COVID-19

Researchers assessed naïve B cells and autoreactivity in severe COVID-19.

2 Sep 2022

The effects of SARS-CoV-2 infection on antibody and B-cell responses to a third dose of mRNA vaccination

Researchers assessed the impact of COVID-19 infection on B-cell and antibody responses to COVID-19 booster vaccination.

2 Sep 2022

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

Researchers develop novel therapeutic strategy to treat Huntington's disease

Through an international joint research effort involving ProQR Therapeutics of the Netherlands, Université Grenoble Alpes of France, and KTH Royal Institute of Technology of Sweden, Professor Ji-Soon Song's research team in the Department of Biological Sciences and KAIST Institute for BioCentury of KAIST, established a noble strategy to treat Huntington's disease. The new works showed that the protein converted from disease form to its disease-free form maintains its original function, providing new roadblocks to approach Huntington's disease.

2 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

In a new study, researchers assessed the effects of N501Y mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein on binding to angiotensin-converting enzyme-2 (ACE-2).

1 Sep 2022

Detection of a novel bird flu virus with pandemic potential

A recent virological study published in the Emerging Infectious Diseases journal identified the novel influenza A virus (H3N8) in live poultry in Hong Kong, genetically similar to the zoonotic H3N8 viruses reported in mainland China with its origin akin to H5N1, H5N6, H10N8, and H7N9 viruses.

31 Aug 2022

The most recent evidence about phylogenesis, pathogenesis, prevention, and treatment for monkeypox

A new review sheds light on the origins of this virus and recently acquired knowledge about its disease mechanism and the preventive and therapeutic measures appropriate in this situation.

31 Aug 2022

Moffitt study uses computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations

All normal human tissues acquire mutations over time. Some of these mutations may be driver mutations that promote the development of cancer through increased proliferation and survival, while other mutations may be neutral passenger mutations that have no impact on cancer development.

30 Aug 2022

Study reinforces the potential of Huntington’s treatments that target glia cells

Huntington's disease – a hereditary and fatal genetic disorder – has long been considered a neuronal disease due to the permanent loss of medium spiny motor neurons, the death of which over time is responsible for the clinical hallmarks of the disease: involuntary movements, problems with coordination, cognitive decline, depression, and psychosis.

30 Aug 2022

Mutation News and Research

Discovery of antibodies that may eliminate the need for COVID vaccines

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

Techniques used for SARS-CoV-2 detection in body fluids

New method accurately analyzes genomics data in cancer archival biopsies

Sensitivity of SARS-CoV-2 Omicron BA.2.75 to neutralization by monoclonal antibodies and sera

Bringing flexibility to Sanger sequencing and DNA-fragment analysis with the Spectrum Compact CE System

Study uncovers the evolutionary dynamics of SARS-CoV-2 at primary stage of massive vaccination

What is currently known about immune responses to COVID-19 vaccines and cellular immune responses against SARS-CoV-2?

The origins, breadth, and resolution of autoreactivity in severe COVID-19

The effects of SARS-CoV-2 infection on antibody and B-cell responses to a third dose of mRNA vaccination

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

Researchers develop novel therapeutic strategy to treat Huntington's disease

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

Detection of a novel bird flu virus with pandemic potential

The most recent evidence about phylogenesis, pathogenesis, prevention, and treatment for monkeypox

Moffitt study uses computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations

Study reinforces the potential of Huntington’s treatments that target glia cells

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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