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Study opens the door to new possibilities targeting telomeres to help treat cancer

The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre continues to make progress in unraveling the role that telomeres -the ends of chromosomes that are responsible for cellular aging as they shorten- play in cancer.

10 Mar 2021

Study describes the infection of human cells by intestinal pathogen during spaceflight

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

9 Mar 2021

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

Scientists from the United States has recently evaluated the safety and efficacy profiles of ultraviolet-A (UVA) light applied via an endotracheal tube to critically ill COVID-19 patients.

9 Mar 2021

New biosensor measures extracellular hydrogen peroxide levels with nanometer-resolution

Several processes in the human body are regulated by biochemical reactions involving hydrogen peroxide (H2O2).

8 Mar 2021

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP—the standard treatment regimen.

8 Mar 2021

A sneak peek of the current state and future use of artificial intelligence in pathology

Artificial intelligence can already scan images of the eye to assess patients for diabetic retinopathy, a leading cause of vision loss, and find evidence of strokes on brain CT scans.

8 Mar 2021

SARS-CoV-2-derived mutant peptides hamper T cells' ability to recognize and destroy infected cells

A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells.

4 Mar 2021

A region within GLI1 gene could potentially be targeted as cancer treatment

Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene's expression.

1 Mar 2021

A backbone free energy study of SARS-CoV-2 variants of concern

A recent study by scientist Robert Penner at the Institut des Hautes Études Scientifiques in France utilizes free energy calculations to predict effective antiviral targets that are highly conserved, surface-accessible for interaction, and resistant to mutation.

1 Mar 2021

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties.

27 Feb 2021

Retroviruses invading the koala germline contribute to high cancer rates

Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year’s devastating bush fires – domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer.

26 Feb 2021

Scientists receive grant to investigate tumor development within a natural environment

Unlike many of us during the COVID-19 pandemic, biological cells are not isolated from the outside world. Chemical variations, intercellular activity, and other microenvironmental factors impact cell survival.

25 Feb 2021

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s

Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimer's disease (AD) and appears in approximately 90% of all patients.

25 Feb 2021

SNX-5422 could make an effective COVID-19 prophylactic, says study

SNX-5422 is a heat shock protein 90 (Hsp90) inhibitor currently undergoing clinical trials as a cancer therapeutic. A recent study examines the applicability of repurposing the drug towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication inhibition.

25 Feb 2021

KTH researchers identify 300 proteins that regulate cell division process

With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins.

24 Feb 2021

Tumors use unique mechanism to switch on regulatory T cells for protection

Immunologists at St. Jude Children's Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system.

24 Feb 2021

Risk models for West Nile Fever may predict areas of future outbreaks a year in advance

Knowing the environmental and human-related variables that characterize the favorable areas for the incidence of the West Nile virus, a flavivirus that is transmitted from birds to humans by mosquitoes, is essential to identify those places in Europe at high risk of experiencing outbreaks, even before these are registered, thus enabling preventive measures to be taken.

24 Feb 2021

Live attenuated SARS-CoV-2 vaccine candidate shows protective efficacy in vivo

A new preprint on the bioRxiv* server describes the development of a live attenuated vaccine candidate to counter the growing threat of the COVID-19 pandemic.

19 Feb 2021

COVID-19 and lung cancer have a common pathway, say researchers

A new preprint on the bioRxiv* server describes the common features COVID-19 shares with lung cancer.

19 Feb 2021

Proliferation News and Research

Study opens the door to new possibilities targeting telomeres to help treat cancer

Study describes the infection of human cells by intestinal pathogen during spaceflight

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

New biosensor measures extracellular hydrogen peroxide levels with nanometer-resolution

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

A sneak peek of the current state and future use of artificial intelligence in pathology

SARS-CoV-2-derived mutant peptides hamper T cells' ability to recognize and destroy infected cells

A region within GLI1 gene could potentially be targeted as cancer treatment

A backbone free energy study of SARS-CoV-2 variants of concern

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Retroviruses invading the koala germline contribute to high cancer rates

Scientists receive grant to investigate tumor development within a natural environment

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s

SNX-5422 could make an effective COVID-19 prophylactic, says study

KTH researchers identify 300 proteins that regulate cell division process

Tumors use unique mechanism to switch on regulatory T cells for protection

Risk models for West Nile Fever may predict areas of future outbreaks a year in advance

Live attenuated SARS-CoV-2 vaccine candidate shows protective efficacy in vivo

COVID-19 and lung cancer have a common pathway, say researchers

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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