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S-2-hydroxyglutarate keeps endothelial cells in a dormant state, reveals study

The inner surface of blood vessels is lined by a wafer-thin layer of cells known as the endothelium, which forms a crucial barrier between blood and the surrounding tissue.

16 Apr 2021

Trial results show leishmaniasis vaccine is safe and induces immune responses in patients

The results of the first clinical trial of a new vaccine for a neglected tropical disease have demonstrated that it is safe and induces immune responses in patients with the infection.

15 Apr 2021

Medical EdTech specialist, Continulus forms partnership with the Australian Sepsis Network

Continulus has formed a global partnership with the highly regarded Australian Sepsis Network (ASN).

From Continulus 15 Apr 2021

Biognosys announces strategic agreement with Siemens Healthineers

Biognosys announces today that it has established a strategic agreement with Siemens Healthineers through its clinical laboratory in Berkeley, California.

From Biognosys 14 Apr 2021

ACE2 homology in laboratory and wild animals

A new preprint research paper posted to the bioRxiv server describes the conservation of an important receptor gene for the virus among several animal species that live in close contact or proximity to humans.

13 Apr 2021

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion.

13 Apr 2021

Study shows how nitrate controls gene expression in legumes

Plants in the bean family (legumes) form nodules on their roots to take up nitrogen. Legumes will stop nodule production when nitrogen is plentiful, but precisely how nitrate presence controls nodule formation in these plants has been a mystery.

12 Apr 2021

Previously approved drugs starting points for COVID-19 therapeutics

Researchers in the United States have identified several clinically approved compounds that could be repurposed for the treatment and prevention of coronavirus disease 2019 (COVID-19).

11 Apr 2021

New consortium aims to accelerate development of stem cell-based therapies for Huntington’s disease

The Stem Cells for Huntington's Disease (SC4HD) is a new international consortium created to promote advanced therapy medicinal product (ATMP) through cell transplantation studies on Huntington's Disease.

9 Apr 2021

PNA-based gene editing technique can advance gene discovery

In an article published in the April 8 issue of Nature, the National Institutes of Health's Somatic Cell Gene Editing Consortium provided a detailed update on the progress of their nationwide effort to develop safer and more effective methods to edit the genomes of disease-relevant somatic cells and reduce the burden of disease caused by genetic changes.

8 Apr 2021

Phase II of Singapore's National Precision Medicine strategy to begin in April 2021

Precision medicine is part of Singapore's Research, Innovation and Enterprise (RIE) 2025 strategic goal to transform and protect the health of every Singaporean.

7 Apr 2021

'Brain glue' may aid in functional neural repair after severe TBI

At a cost of $38 billion a year, an estimated 5.3 million people are living with a permanent disability related to traumatic brain injury in the United States today, according to the Centers for Disease Control and Prevention.

6 Apr 2021

New solar-powered water filter could solve the problem of providing off-grid clean water

A new invention that uses sunlight to drive water purification could help solve the problem of providing clean water off the grid.

1 Apr 2021

New mRNA COVID-19 vaccine candidate shows promise in vivo

Researchers report that a new lipid nanoparticle mRNA coronavirus disease 2019 (COVID-19) vaccine candidate protected 70% of mice expressing the human angiotensin-converting enzyme 2 (ACE2), while all the non-vaccinated mice died.

31 Mar 2021

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Study identifies key features in SARS-CoV-2 genome essential for replication in respiratory cells

Researchers at the Institute of Medical Virology, the University of Zurich in Switzerland, have identified features in the SARS-CoV-2 genome that are important for human respiratory cell growth.

29 Mar 2021

IQWiG releases revised version of its General Methods

The Institute for Quality and Efficiency in Health Care (IQWiG) revised its methods paper and published the German original version "Allgemeine Methoden 6.0" (General Methods 6.0) on http://www.iqwig.de in November 2020.

26 Mar 2021

Study explores the implementation of TWH approach in Latin America

Researchers from the Center for Health, Work & Environment (CHWE) at the Colorado School of Public Health have published a paper in the International Journal of Environmental Research and Public Health studying the effectiveness of applying Total Worker Health (TWH) in an international context.

26 Mar 2021

ColoradoSPH wins NIH grant to study how air pollutants impact kidney health of sugarcane workers

Three groups from the Colorado School of Public Health have been awarded a $3 million 5-year grant from the National Institutes of Health to study the effects of air pollution and climate on the kidney health of sugarcane workers in Guatemala.

25 Mar 2021

Researchers examine SARS-CoV-2 RNA interactome

A new study focuses on the identification of RNA-binding protein by mass spectrometry (ChIRP-M/S) approach. This study develops a global map that contains the complete set of host proteins that involve the SARS-CoV-2 genome during infection. This study has successfully identified new SARS-CoV-2 host dependency factors by merging proteomics data with gene silencing experiments. Such a discovery has paved new roads to develop more antiviral therapies.

25 Mar 2021

Translation News and Research

S-2-hydroxyglutarate keeps endothelial cells in a dormant state, reveals study

Trial results show leishmaniasis vaccine is safe and induces immune responses in patients

Medical EdTech specialist, Continulus forms partnership with the Australian Sepsis Network

Biognosys announces strategic agreement with Siemens Healthineers

ACE2 homology in laboratory and wild animals

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Study shows how nitrate controls gene expression in legumes

Previously approved drugs starting points for COVID-19 therapeutics

New consortium aims to accelerate development of stem cell-based therapies for Huntington’s disease

PNA-based gene editing technique can advance gene discovery

Phase II of Singapore's National Precision Medicine strategy to begin in April 2021

'Brain glue' may aid in functional neural repair after severe TBI

New solar-powered water filter could solve the problem of providing off-grid clean water

New mRNA COVID-19 vaccine candidate shows promise in vivo

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Study identifies key features in SARS-CoV-2 genome essential for replication in respiratory cells

IQWiG releases revised version of its General Methods

Study explores the implementation of TWH approach in Latin America

ColoradoSPH wins NIH grant to study how air pollutants impact kidney health of sugarcane workers

Researchers examine SARS-CoV-2 RNA interactome

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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