Interleukin News and Research

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Short-term infection with intestinal worms may provide long-term protection against TID

Short-term infection with intestinal worms may provide long-term protection against type I diabetes (TID), suggests a study conducted by William Gause, PhD, and colleagues at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School.

20 Jul 2012

Limewater combination therapy can reduce root canal endotoxins

Treating root canals with a combination of chlorhexidine gel and calcium hydroxide results in significant reduction of endotoxins and neutralization of cytotoxic effects compared with the gel plus polymyxin B or saline, report Brazilian researchers.

17 Jul 2012

Identification of IL-9 antitumor activity in melanoma

High expression of interleukin -9 in immune cells inhibits growth of melanoma, show study findings suggesting a role for this T-cell cytokine in tumor suppression.

13 Jul 2012

Altered immune function in relatives of schizophrenia patients

Schizophrenia patients and their unaffected first-degree relatives exhibit immune system alterations compared with mentally healthy individuals, researchers report.

12 Jul 2012

OncoSec establishes UCSF as second enrolling site for OMS-I110 Phase II Merkel cell carcinoma trial

OncoSec Medical Inc., a company developing the advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumors, announces it has established the University of California San Francisco (UCSF) as the second enrolling site for its Phase II Merkel cell carcinoma clinical trial (OMS-I110).

11 Jul 2012

Researchers discover unknown mechanism that promotes growth and spread of cancer

Tiny vesicles released by tumors cells are taken up by healthy immune cells, causing the immune cells to discharge chemicals that foster cancer-cell growth and spread, according to a study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) and at Children's Hospital in Los Angeles.

11 Jul 2012

Biomarkers predict benefit of targeted therapy in metastatic renal-cell cancer

In metastatic renal-cell cancer, the level of cytokines and angiogenic factors identify those patients with an aggressive disease course who derive the greatest benefit from treatment with the molecular-targeted therapy pazopanib, a retrospective analysis of clinical trials shows.

10 Jul 2012

Altered immune function in relatives of schizophrenia patients

Schizophrenia patients and their unaffected first-degree relatives exhibit immune system alterations compared with mentally healthy individuals, researchers report.

10 Jul 2012

Ozone concerns aired over effect on cardiac biomarkers

Exposure to ozone for as little as 2 hours could induce physiologic changes associated with cardiovascular disease, say US researchers.

10 Jul 2012

Specific cytokine levels altered in BD patients

Levels of certain cytokines differ between bipolar disorder patients and mentally healthy individuals, as well as between manic and euthymic patients with the mood disorder, results from a systematic review and meta-analysis show.

10 Jul 2012

High expression of interleukin-9 in immune cells inhibits melanoma growth

Researchers from Brigham and Women's Hospital (BWH) have made a groundbreaking discovery that will shape the future of melanoma therapy. The team, led by Thomas S. Kupper, MD, chair of the BWH Department of Dermatology, and Rahul Purwar, PhD, found that high expression of a cell-signaling molecule, known as interleukin-9, in immune cells inhibits melanoma growth.

9 Jul 2012

Early childhood adversity linked with depression and inflammation

When a person injures their knee, it becomes inflamed. When a person has a cold, their throat becomes inflamed. This type of inflammation is the body's natural and protective response to injury. Interestingly, there is growing evidence that a similar process happens when a person experiences psychological trauma. Unfortunately, this type of inflammation can be destructive.

4 Jul 2012

Platelet activation linked to osteoporosis

Elderly, postmenopausal women with osteoporosis have elevated platelet volumes, report researchers.

2 Jul 2012

Ozone concerns aired over effect on cardiac biomarkers

Exposure to ozone for as little as 2 hours could induce physiologic changes associated with cardiovascular disease, say researchers.

28 Jun 2012

Gene transfer technique eliminates specific neural circuit linked to Parkinson's disease

In the brains of humans and non-human primates, over 100 billion nerve cells build up complicated neural circuits and produce higher brain functions. When an attempt is made to perform gene therapy for neurological diseases like Parkinson's disease, it is necessary to specify a responsible neural circuit out of many complicated circuits.

27 Jun 2012

Ozone exposure associated with cardiovascular ailments

Young, healthy adult volunteers exposed for two hours to ozone developed physiological changes associated with cardiovascular ailments, according to a small study reported in Circulation, an American Heart Association journal.

26 Jun 2012

REG3A molecule may lead to new treatments for psoriasis, wound-healing

Psoriasis is an autoimmune disorder in which skin cells proliferate out of control. For some hard-to-heal wounds, the problem is just the opposite: Restorative skin cells don't grow well or fast enough. In a paper published in the June 21, 2012 issue of Immunity, researchers at the University of California, San Diego School of Medicine describe a molecule that may lead to new treatments for both problems.

22 Jun 2012

Omega-3 fatty acid supplements can reduce inflammation in overweight older adults

New research shows that omega-3 fatty acid supplements can lower inflammation in healthy, but overweight, middle-aged and older adults, suggesting that regular use of these supplements could help protect against and treat certain illnesses.

21 Jun 2012

Western-style diets may increase risk of inflammatory bowel disease

Certain saturated fats that are common in the modern Western diet can initiate a chain of events leading to complex immune disorders such as inflammatory bowel diseases (IBD) in people with a genetic predisposition, according to a study to be published early online in the journal Nature.

14 Jun 2012

STELARA effectively reduces signs and symptoms of active psoriatic arthritis

Patients with active psoriatic arthritis receiving the interleukin (IL)-12/23 inhibitor STELARA (ustekinumab) experienced significant improvements in signs and symptoms of the disease, according to new findings presented today from a Janssen Research & Development, LLC, (Janssen)-sponsored investigational study.

6 Jun 2012