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Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third-generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm.

11 Dec 2023

UMSOM receives $29 million research award to improve health outcomes in people who inject opioid drugs

University of Maryland School of Medicine Dean Mark T. Gladwin, MD, announced today that the school will receive a $29 million research award over four years from the National Institutes of Health to lead a multicenter trial that aims to improve health outcomes in people who inject opioid drugs and are hospitalized with infectious complications of their drug use.

11 Dec 2023

Research uncovers potential treatment target for rare, genetic type of epilepsy

Researchers at the Francis Crick Institute, UCL and MSD have identified a potential treatment target for a genetic type of epilepsy.

11 Dec 2023

Highly bioavailable, pure form of astaxanthin safely fights inflammaging to improve lifespan

AX3 Life announced breakthrough life extension findings related to its longevity supplement, AX3® Bio-Pure Astaxanthin.

11 Dec 2023

Cryo-EM reveals TAF15 as potential treatment target for frontotemporal dementia

An international team of researchers including experts at the Indiana University School of Medicine has identified a protein found in the brains of people with frontotemporal dementia (FTD), discovering a new target for potential treatments for the disease.

7 Dec 2023

Liver trigger holds the key to boosting gene therapy success

Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

7 Dec 2023

Maternal inflammation risk factors linked to dysregulation in children

Maternal inflammation risk factors may be associated with dysregulation in children, according to a study funded by the Environmental influences on Child Health Outcomes (ECHO) Program at the National Institutes of Health.

7 Dec 2023

New early phase study evaluates “on-demand” HIV prevention method for women

A fast-dissolving vaginal insert that women would use at or around the time of sex as an "on-demand" HIV prevention method is being evaluated in a new early phase study being conducted by MATRIX, a United States Agency for International Development (USAID)-funded project focused on the early research and development of innovative HIV prevention products for women.

7 Dec 2023

Exercise may become part of standard treatment for metastatic breast cancer, study suggests

Among patients with metastatic breast cancer, those who took part in a nine-month structured exercise program reported less fatigue and an improved quality of life compared to those who did not undergo the exercise program, according to results from the PREFERABLE-EFFECT trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

7 Dec 2023

Ashwagandha extracts show promise in reducing stress hormones, study suggests

A systematic review reveals that Withania somnifera (Ashwagandha) extracts can effectively reduce cortisol levels in the short term, offering a natural alternative for stress management, though long-term effects remain unexplored.

6 Dec 2023

Design modifications offer promise for safer and more effective mRNA therapeutics

Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body.

6 Dec 2023

Scientists uncover key protein aggregation in frontotemporal dementia

Most neurodegenerative diseases, including dementias, involve proteins aggregating into filaments called amyloids.

6 Dec 2023

Military personnel repeatedly exposed to blasts show increased brain inflammation and structural changes

The brains of special warfare community personnel repeatedly exposed to blasts show increased inflammation and structural changes compared with a control group, potentially increasing the risk of long-term, brain-related disease, according to a new study.

6 Dec 2023

Trial addresses the effects of adenotonsillectomy on children with mild sleep-disordered breathing

Surgical removal of the tonsils and adenoids in children with snoring and mild breathing problems during sleep appears to improve their sleep, quality of life, and blood pressure a year after surgery, a clinical trial supported by the National Institutes of Health has found.

5 Dec 2023

Study may shed light on new ways to counteract the effects of high blood pressure on cognition

A study supported by the National Institutes of Health suggests that the response of immune system cells inside the protective covering surrounding the brain may contribute to the cognitive decline that can occur in a person with chronic high blood pressure.

5 Dec 2023

Common dietary supplement could protect against chronic Cryptosporidium infections

Researchers at the Francis Crick Institute have discovered that a common dietary supplement could protect against chronic Cryptosporidium infections which are particularly prevalent in children under two and in areas with poorer sanitation.

4 Dec 2023

Postpartum phagocytosis of pancreatic β-cells by macrophages regulates blood glucose levels

Pancreatic beta cells (β-cells) reside in a cluster of cells in the pancreas known as the islets of Langerhans.

4 Dec 2023

Pancreatic vagus nerve stimulation boosts insulin production in mice

Insulin is a hormone that decreases blood glucose levels. The only cells that produce insulin are pancreatic beta cells (β-cells), and a decrease in these cells is a major cause of diabetes.

4 Dec 2023

Neuroimaging and network modeling tools shed light on Alzheimer's disease in animal models

Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools - previously developed to analyze brains of patients in the clinic - to investigate Alzheimer's disease progression in preclinical animal models.

4 Dec 2023

Hispanic/Latina women with history of hypertensive disorders of pregnancy more likely to have heart abnormalities

Hispanic/Latina women with a history of hypertensive disorders of pregnancy (HDP) – conditions marked by high blood pressure during pregnancy – are more likely to have abnormalities in their heart structure and function decades later when compared with women without a history of HDP, according to a National Institutes of Health-supported study.

4 Dec 2023

Medical Research News and Research

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

UMSOM receives $29 million research award to improve health outcomes in people who inject opioid drugs

Research uncovers potential treatment target for rare, genetic type of epilepsy

Highly bioavailable, pure form of astaxanthin safely fights inflammaging to improve lifespan

Cryo-EM reveals TAF15 as potential treatment target for frontotemporal dementia

Liver trigger holds the key to boosting gene therapy success

Maternal inflammation risk factors linked to dysregulation in children

New early phase study evaluates “on-demand” HIV prevention method for women

Exercise may become part of standard treatment for metastatic breast cancer, study suggests

Ashwagandha extracts show promise in reducing stress hormones, study suggests

Design modifications offer promise for safer and more effective mRNA therapeutics

Scientists uncover key protein aggregation in frontotemporal dementia

Military personnel repeatedly exposed to blasts show increased brain inflammation and structural changes

Trial addresses the effects of adenotonsillectomy on children with mild sleep-disordered breathing

Study may shed light on new ways to counteract the effects of high blood pressure on cognition

Common dietary supplement could protect against chronic Cryptosporidium infections

Postpartum phagocytosis of pancreatic β-cells by macrophages regulates blood glucose levels

Pancreatic vagus nerve stimulation boosts insulin production in mice

Neuroimaging and network modeling tools shed light on Alzheimer's disease in animal models

Hispanic/Latina women with history of hypertensive disorders of pregnancy more likely to have heart abnormalities

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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