Transcription News and Research

RSS

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

A recent study under review at Nature Portfolio and posted to the Research Square* preprint server depicted how cellular nucleic acid-binding protein (CNBP) inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Researchers demonstrated that plasma levels of leucine-rich repeat-containing 15 are a strong indicator of the severity of COVID-19 in patients with end-stage kidney disease.

3 May 2022

Epidemiologic and genomic investigation of SARS-CoV-2 infections associated with two repatriation flights from India to Australia

Researchers conducted epidemiologic and genomic studies to investigate in-flight SARS-CoV-2 infection associated with repatriation flights from India to Australia in April 2021.

3 May 2022

Prior SARS-CoV-2 infection provides substantial and sustained protection from Omicron hospitalization

A population-level study conducted on residents of the Quebec province, Canada, has demonstrated that prior infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces robust and long-lasting protection against omicron re-infection and hospitalization. The level of protection further increases with coronavirus disease 2019 (COVID-19) vaccination.

3 May 2022

Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development.

2 May 2022

Tracking BA.2.12.1 🦠 by partial ORF1ab gene 🧬 target failure (pOGTF)

Scientists from the United States have recently identified a novel approach to rapidly and accurately detect the omicron BA.2.12.1 sub-lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples.

2 May 2022

Neutralizing antibodies produced following COVID-19 BNT162b2 vaccine found to activate complement cascade

Researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) produced following COVID-19 vaccination.

2 May 2022

Epigenetic abnormalities in hematopoietic cells during fetal development cause idiopathic autism

An international research group led by Professor Toru Takumi (Senior Visiting Scientist, RIKEN Center for Biosystems Dynamics Research) and Researcher Chia-wen Lin at Kobe University Graduate School of Medicine has shown that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells during fetal development, which results in immune dysregulation in the brain and gut.

2 May 2022

SARS-CoV-2 viral shedding varies widely in asymptomatic and mildly ill patients

In a recent study published in the Nature Microbiology journal, researchers assessed the longitudinal viral dynamics in asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

1 May 2022

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.

29 Apr 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Artificial circular RNAs found to bypass cellular antiviral responses

Researchers produced artificial circular ribonucleic acid sponges in a permuted intron-exon system and showed that these did not activate innate immunity.

29 Apr 2022

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

A recent study published in the journal Immunology analyzed whether sex mattered in the immune response to SARS-CoV-2.

29 Apr 2022

New insights into how NANOG protein facilitates the activation of human cell pluripotency

There are cells in the body known as pluripotent stem cells that are yet to specialize in a particular biological function.

28 Apr 2022

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

In a recent study published in Biomedicines, researchers explored the utility of natural killer (NK) cells in coronavirus disease 2019 (COVID-19).

28 Apr 2022

A cigarette smoke compound affects cartilage homeostasis

Cigarette smoke has been shown to deleteriously affect human health. For example, degenerative disc diseases are increasingly linked to cigarette smoking.

28 Apr 2022

Misexpression of non-cardiac genes may lead to congenital heart disease

Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.

27 Apr 2022

Findings of the HITCH randomized clinical trial show lack of improvement in COVID-19 on temporary androgen suppression

Researchers investigated whether temporary androgen suppression by degarelix improved the clinical outcomes among male patients hospitalized with COVID-19.

27 Apr 2022

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

Researchers revealed that native FokI relaxation might be induced, resulting in FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids.

27 Apr 2022

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Mount Sinai researchers have discovered a previously unknown mechanism in which not-yet-malignant cells from early breast cancer tumors travel to other organs and, eventually, "turn on" and become metastatic breast cancer.

26 Apr 2022

Transcription News and Research

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

Multi-omics identify COVID-19 severity predictors and prothrombotic signatures in patients with end-stage kidney disease

Epidemiologic and genomic investigation of SARS-CoV-2 infections associated with two repatriation flights from India to Australia

Prior SARS-CoV-2 infection provides substantial and sustained protection from Omicron hospitalization

Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

Tracking BA.2.12.1 🦠 by partial ORF1ab gene 🧬 target failure (pOGTF)

Neutralizing antibodies produced following COVID-19 BNT162b2 vaccine found to activate complement cascade

Epigenetic abnormalities in hematopoietic cells during fetal development cause idiopathic autism

SARS-CoV-2 viral shedding varies widely in asymptomatic and mildly ill patients

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Artificial circular RNAs found to bypass cellular antiviral responses

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

New insights into how NANOG protein facilitates the activation of human cell pluripotency

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

A cigarette smoke compound affects cartilage homeostasis

Misexpression of non-cardiac genes may lead to congenital heart disease

Findings of the HITCH randomized clinical trial show lack of improvement in COVID-19 on temporary androgen suppression

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News