Immune System News and Research

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Death risk for marathon runners remains low during or soon after race

Even though hundreds of thousands more people finished grueling 26.2 mile marathons in the United States in 2009 compared to a decade earlier, a runner’s risk of dying during or soon after the race has remained very low — about .75 per 100,000, new Johns Hopkins research suggests. Men, however, were twice as likely to die as women.

16 May 2012

AAD reiterates safety and effectiveness of sunscreens against UV radiation

The American Academy of Dermatology (Academy) today reiterated the safety and effectiveness of sunscreens to protect against the damaging effects from exposure to ultraviolet (UV) radiation.

16 May 2012

Combination of vaccine and letrozole effectively improves survival from breast cancer

A vaccine that targets cancer cells in combination with the drug letrozole, a standard hormonal therapy against breast cancer, significantly increased survival when tested in mice, a team of UC Davis investigators has found.

16 May 2012

Two new mouse models can help treat food allergies

Food allergies pose a serious and growing problem in the West. Many foods can lead to allergic reactions and this situation is further complicated by so-called cross-reactions, whereby an allergy to one particular food can trigger allergic reactions to another food. There are no treatments available for food allergies, but the establishment of two mouse models can be used to develop and test new forms of treatment, for example vaccines.

16 May 2012

Galectin Therapeutics commences Phase 1/2 trial of new treatment combination for advanced MM

Galectin Therapeutics, the leader in developing carbohydrate-based therapeutic compounds to inhibit galectin proteins for the therapy of liver fibrosis and cancer, today announced that the first patient has been dosed in a Phase 1/2 trial evaluating the safety and efficacy of a novel treatment combination for the treatment of advanced metastatic melanoma.

16 May 2012

Cyclophosphamide drug makes the bone marrow more tumor-friendly

Researchers found that administering a common chemotherapy drug before bone tumors took root actually fertilized the bone marrow, enabling cancer cells, once introduced, to seed and grow more easily.

15 May 2012

HMO critically important in understanding how breastfeeding protects babies

A new University of Illinois study shows that human milk oligosaccharides, or HMO, produce short-chain fatty acids that feed a beneficial microbial population in the infant gut. Not only that, the bacterial composition adjusts as the baby grows older and its needs change.

15 May 2012

Human embryonic stem cells can be used to grow bone tissue grafts

Dr. Darja Marolt, an Investigator at The New York Stem Cell Foundation (NYSCF) Laboratory, is lead author on a study showing that human embryonic stem cells can be used to grow bone tissue grafts for use in research and potential therapeutic application. Dr. Marolt conducted this research as a post-doctoral NYSCF - Druckenmiller Fellow at Columbia University in the laboratory of Dr. Gordana Vunjak-Novakovic.

15 May 2012

Biovest plans to file BiovaxID MAA with EMA for treatment of follicular NHL

Biovest International, Inc., a majority-owned subsidiary of Accentia Biopharmaceuticals, Inc., today announced that Biovest plans to file for marketing approval in the European Union (EU) for BiovaxID, its personalized cancer vaccine for the treatment of follicular non-Hodgkin's lymphoma, an incurable cancer of the immune system.

14 May 2012

Researchers uncover new way to stimulate activity of immune cell opiate receptors

Researchers at Rutgers University have uncovered a new way to stimulate activity of immune cell opiate receptors, leading to efficient tumor cell clearance.

14 May 2012

Naked mole rat's proteasome assemblies differ in composition from other short-lived rodents

The naked mole rat, a curiously strange, hairless rodent, lives many years longer than any other mouse or rat. Scientists at The University of Texas Health Science Center San Antonio's Barshop Institute of Longevity and Aging Studies continue to explore this mystery.

14 May 2012

Study describes new compounds that inhibit PRMT1 enzyme

Scientists at The Scripps Research Institute have found the first chemical compounds that act to block an enzyme that has been linked to inflammatory conditions such as asthma and arthritis, as well as some inflammation-promoted cancers.

11 May 2012

New insights into how body's innate immunity is triggered to create effective immune response

Singapore scientists from Bioprocessing Technology Institute (BTI) under the Agency of Science, Technology and Research (A*STAR) have for the first time, identified the molecular 'switch' that directly triggers the body's first line of defence against pathogens, more accurately known as the body's "innate immunity".

11 May 2012

Study reveals sex-specific fitness benefit of variability of MHC genes

Females of mammals (including humans) tend to outlive males, a circumstance that is usually attributed to males- more aggressive and hence energy-depleting behaviour, especially when they compete for females. This might also explain why males of many species usually show a higher parasite burden than females.

11 May 2012

FDA warns about 'liberation therapy' for multiple sclerosis

The U.S. Food and Drug Administration is alerting health care professionals and patients about injuries and death associated with the use of an experimental procedure sometimes called "liberation therapy" or the "liberation procedure" to treat chronic cerebrospinal venous insufficiency (CCSVI).

11 May 2012

Bacteria in digestive tracts compete against invading bacteria

From tiny villages in developing nations to suburban kitchens in the United States, dangerous strains of E. coli bacteria sicken millions of people each year - and kill untold numbers of children.

11 May 2012

New combination therapy offers potential lifetime cure for advanced type 1 diabetes

City of Hope researchers developed a combination therapy to treat late-stage type 1 diabetes that appears to offer a potential lifetime cure for the disease without toxic side effects. The laboratory study is published in the May 9 edition of Science Translational Medicine.

11 May 2012

African-Americans with scleroderma have more antibodies linked to severe complications

A new analysis finds that compared to Caucasians, African-Americans with systemic scleroderma have more antibodies in the blood that are linked to severe complications and an increased likelihood of death. They say this finding, published today in Arthritis & Rheumatism, suggests physicians can use these disease markers to screen and treat scleroderma patients proactively.

11 May 2012

Ixmyelocel-T shows promise against progressive heart failure

An investigational therapy derived from a patient's own bone marrow stem cells improves heart function in some patients with progressive heart failure due to dilated cardiomyopathy (DCM), according to the results of a Phase 2a study presented today as a late-breaking clinical trial at the SCAI 2012 Scientific Sessions.

11 May 2012

Maternal gluten sensitivity may increase risk of schizophrenia in children

Babies born to women with sensitivity to gluten appear to be at increased risk for certain psychiatric disorders later in life, according to research by scientists at Karolinska Institutet in Sweden and Johns Hopkins Children's Center in Baltimore.

11 May 2012

Immune System News and Research

Death risk for marathon runners remains low during or soon after race

AAD reiterates safety and effectiveness of sunscreens against UV radiation

Combination of vaccine and letrozole effectively improves survival from breast cancer

Two new mouse models can help treat food allergies

Galectin Therapeutics commences Phase 1/2 trial of new treatment combination for advanced MM

Cyclophosphamide drug makes the bone marrow more tumor-friendly

HMO critically important in understanding how breastfeeding protects babies

Human embryonic stem cells can be used to grow bone tissue grafts

Biovest plans to file BiovaxID MAA with EMA for treatment of follicular NHL

Researchers uncover new way to stimulate activity of immune cell opiate receptors

Naked mole rat's proteasome assemblies differ in composition from other short-lived rodents

Study describes new compounds that inhibit PRMT1 enzyme

New insights into how body's innate immunity is triggered to create effective immune response

Study reveals sex-specific fitness benefit of variability of MHC genes

FDA warns about 'liberation therapy' for multiple sclerosis

Bacteria in digestive tracts compete against invading bacteria

New combination therapy offers potential lifetime cure for advanced type 1 diabetes

African-Americans with scleroderma have more antibodies linked to severe complications

Ixmyelocel-T shows promise against progressive heart failure

Maternal gluten sensitivity may increase risk of schizophrenia in children

Understanding the DNA Damage Response in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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