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Could the mTOR pathway be used to protect against cancer?

The mTOR pathway is probably the main pathway in humans and other animals that drives growth. That is, the accumulation of mass and adding mass to make an organism bigger by both making more cells, and making cells grow and become bigger.

22 Jun 2017

Researchers show effective oral treatment option for patients with rheumatoid arthritis

Patients suffering from rheumatoid arthritis are treated for around six months with the standard anti-rheumatic agent methotrexate, to which many patients respond very well.

19 Jun 2017

Research details how lymphoma cells acquire resistance to targeted therapy

Today some patients suffering with mantle cell lymphoma, a type of blood cancer, can be treated with a pill called Ibrutinib, forgoing conventional chemotherapy. However, many are developing a resistance to this treatment.

15 Jun 2017

Researchers discover how mutations in protein network drive high-risk leukemias

Researchers have uncovered how mutations in a protein network drive several high-risk leukemias, offering new prospects for novel therapies.

14 Jun 2017

Researchers find molecule that darkens skin without UV exposure and may protect against skin cancer

A study published in the journal Cell on June 13 has found that a class of small molecules can successfully penetrate and darken human skin samples. The drug developed in the laboratory by researchers in Boston also generates protective tans in red-haired mice.

14 Jun 2017

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Researchers from the Institute of Neurosciences of the UB and from IDIBAPS together with a team from the University Pierre and Marie Curie and the Institute du Fer à Moulin, published a study in Nature Communications, which demonstrates that the regulation in Pyk2, a protein-tyrosine kinase, causes alterations of the synaptic plasticity involved in memory tasks, associated with the hippocampus in mouse models of neurodegenerative diseases, such as Huntington's.

13 Jun 2017

Findings point to potential new treatment for people with newly diagnosed EGFR-positive NSCLC

Findings from a phase III clinical trial point to a potential new treatment for patients newly diagnosed with advanced, epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC).

5 Jun 2017

Novartis, Bristol-Myers Squibb collaborate to examine combination therapies for metastatic colorectal cancer

Novartis today announced it has entered into a clinical research collaboration in which Bristol-Myers Squibb will investigate the safety, tolerability, and efficacy of Mekinist (trametinib) in combination with Opdivo (nivolumab) and Opdivo + Yervoy (ipilimumab) regimen as a potential treatment option for metastatic colorectal cancer in patients with microsatellite stable tumors where the tumors are proficient in mismatch repair (MSS mCRC pMMR).

5 Jun 2017

New targeted oral therapy results in durable responses across many kinds of cancer

Scientists may have developed the first targeted, oral, tumor-type agnostic therapy - a cancer medicine that works comparably well across many kinds of cancer, regardless of patient age. In clinical trials of adults and children with 17 different types of advanced cancer, larotrectinib treatment resulted in responses in 76% of patients.

5 Jun 2017

Combination therapy shows potential for effective treatment of RAS-mutant cancers

A study at The University of Texas MD Anderson Cancer Center has shown promise for effective treatment of therapy-resistant cancers caused by a mutation of the RAS gene found in many cancers.

2 Jun 2017

Scientists locate crucial off-switch for central cell control

As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes array.

2 Jun 2017

Collaborative effort to develop rare disease patient registries

The Orphan Disease Center in the Perelman School of Medicine at the University of Pennsylvania will collaborate with Pulse Infoframe Inc., a medical informatics company, to develop rare disease patient registries aimed at enabling international collaboration to better understand these diseases, as well as accelerate and improve clinical studies to develop new therapies.

31 May 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

FDA approves expanded use of Zykadia for first-line treatment of ALK-positive metastatic NSCLC

Novartis today announced the US Food and Drug Administration approved the expanded use of Zykadia (ceritinib) to include the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive, as detected by an FDA-approved test.

27 May 2017

Innate genetic advantage contributes to better outcomes in newborn infant girls than boys, research shows

Newborn infant girls have better outcomes than their male counterparts due to an innate genetic advantage in responding to acute infections, according to new research from RCSI.

26 May 2017

Georgia State researchers renew $2.3 million federal grant for diabetic vascular disease research

Dr. Ming-Hui Zou, director of the Center for Molecular & Translational Medicine and a Georgia Research Alliance Eminent Scholar in Molecular Medicine, has renewed a four-year, $2.3 million federal grant to study the role of an enzyme in causing diabetic vascular diseases and the molecular mechanism that leads to these diseases.

25 May 2017

Enzyme Indicators proven as valuable tool for validation of hydrogen peroxide decontamination processes

Enzyme Indicators (EI’s) have been proven as a revolutionary viable alternative to biological indicators (BI’s) for Hydrogen Peroxide decontamination validation.

25 May 2017

Feinstein Institute honors Sir Paul Nurse with Cerami Award for cancer research

Northwell Health's Feinstein Institute for Medical Research and Molecular Medicine announced today that the seventh Anthony Cerami Award in Translational Medicine will be awarded to Sir Paul Nurse, PhD, director of The Francis Crick Institute.

24 May 2017

Cancer drug may help treat food allergies

A cancer drug for patients with certain types of leukemia and lymphoma can also prevent reactions to some of the most common airborne allergies, according to a recent Northwestern Medicine study. The promising data from this pilot study could have greater implications for adults with food allergies.

22 May 2017

Hormetic cognitive stress from exposure to technology may reduce age-related disease

It appears inevitable that technology is increasingly taking over our lives. However, it seems that it can also help us avoid aging and age-related disease, in a way that has not been described before.

19 May 2017

Kinase News and Research

Could the mTOR pathway be used to protect against cancer?

Researchers show effective oral treatment option for patients with rheumatoid arthritis

Research details how lymphoma cells acquire resistance to targeted therapy

Researchers discover how mutations in protein network drive high-risk leukemias

Researchers find molecule that darkens skin without UV exposure and may protect against skin cancer

Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Findings point to potential new treatment for people with newly diagnosed EGFR-positive NSCLC

Novartis, Bristol-Myers Squibb collaborate to examine combination therapies for metastatic colorectal cancer

New targeted oral therapy results in durable responses across many kinds of cancer

Combination therapy shows potential for effective treatment of RAS-mutant cancers

Scientists locate crucial off-switch for central cell control

Collaborative effort to develop rare disease patient registries

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

FDA approves expanded use of Zykadia for first-line treatment of ALK-positive metastatic NSCLC

Innate genetic advantage contributes to better outcomes in newborn infant girls than boys, research shows

Georgia State researchers renew $2.3 million federal grant for diabetic vascular disease research

Enzyme Indicators proven as valuable tool for validation of hydrogen peroxide decontamination processes

Feinstein Institute honors Sir Paul Nurse with Cerami Award for cancer research

Cancer drug may help treat food allergies

Hormetic cognitive stress from exposure to technology may reduce age-related disease

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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