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Scientists identify a new pneumococcal vaccine candidate

Researchers at Karolinska Institutet in Sweden have identified a new vaccine candidate against pneumococci, bacteria that can cause pneumonia, sepsis, and meningitis.

2 Jun 2022

Scientists characterize a novel zoonotic coronavirus in humans

Scientists characterize the spike protein structure, entry receptors, and antigenicity of the newly emerged CCoV-HuPn-2018.

2 Jun 2022

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

Researchers looked into the role played by the accessory proteins using synthetic genomics assembly technology

2 Jun 2022

Nectar of common plants could be used to help fight Leishmania infections

The nectar of common plants such as sunflower contain bioactive agents that can inhibit the growth of Leishmania and could be used to help fight the potentially fatal disease caused by the parasite, say researchers.

2 Jun 2022

Membrane lipid stops stress reactions and inhibits cell death

Programmed cell death is an important tool that an organism uses to keep itself healthy. When a cell does not function as it should, various stress reactions are activated. The goal of these reactions is to restore the original cell function.

1 Jun 2022

New findings reveal potential mechanisms for cellular defects in human laminopathies

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the Proceedings of the National Academy of Sciences.

1 Jun 2022

Effectiveness of copper nanoparticle-based spray coating against SARS-CoV-2

Researchers demonstrate how copper NPs can potentially be incorporated into filters, PPE, facemasks, and clothing to effectively inactivate SARS-CoV-2.

31 May 2022

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major histocompatibility complex class I (MHC-I) in hosts.

30 May 2022

First-of-its-kind platform generates antitumor immunity and improves responses to checkpoint inhibitors

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade.

30 May 2022

Method for predicting neutralization and protection based on variant-specific antibody measurements to SARS-CoV-2 antigens

Researchers reported a method to predict neutralization and protection against SARS-CoV-2 antigens.

30 May 2022

Researchers investigate gestational diabetes mellitus and its association with maternal and fetal outcomes

Researchers quantify the outcomes of pregnancies complicated by gestational diabetes.

30 May 2022

Research offers entirely new ways to visualize cell membranes

Research from the lab of Matthew Lew at Washington University in St. Louis offers entirely new ways to see the very small.

27 May 2022

Cell membrane-bound enzyme is essential for SARS-CoV-2 infectivity, study shows

The membrane-bound form of angiotensin converting enzyme 2 (ACE2) is essential for enabling infection with SARS-CoV-2, the virus that causes COVID-19, according to a study published in the journal Cell.

26 May 2022

Researchers focus on how bacterial cells adapt and resist antibiotics

Treatment of severe infections caused by pathogenic bacteria relies on ‘last resort’ antibiotics, but rising resistance by ‘superbugs’ to most clinically approved drugs leaves patients exposed to possible fatalities.

26 May 2022

The role of pyroptosis in COVID-19

Researchers investigate the mechanisms by which SARS-CoV-2 induces NLRP3 inflammasome formation leading to pyroptosis.

25 May 2022

Hydration restores airway integrity in people with cystic fibrosis

Cystic fibrosis is a rare genetic disease which can cause very serious symptoms. In particular, patients suffer from chronic bacterial infections that can lead to respiratory failure.

24 May 2022

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Researchers used the SARS-CoV-2 sequence against aptamers to perform the in silico selection of an aptamer against the SARS-CoV-2 S protein.

24 May 2022

Study identifies a gene that plays an important role in embryo development

A new study co-led by a Cedars-Sinai investigator identified a gene that plays an important role in a biological pathway involved in embryo development.

24 May 2022

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

In a recent study posted to the medRxiv* preprint server, investigators in Singapore showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection elicited broadly specific virus-selective nasal resident CD8 and CD4 T cells.

24 May 2022

Study sheds light on the molecular biology behind genetic epilepsy

Sometimes, even the alteration of a single nucleotide in a gene can cause serious disease. In a young boy with epilepsy, this kind of mutation has not just affected the functioning of the protein in question – it could also curb the functioning of several closely related proteins.

23 May 2022