Protein C News and Research

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New findings may help researchers leverage ERAP1 to fight cancer

In a paper published in the Journal of Biological Chemistry, University of Illinois at Chicago researchers and colleagues report a new mechanism for detecting foreign material during early immune responses.

3 Dec 2019

Researchers identify mechanism for spread of HIV-1

New insight on how a type of cell facilitates the spread of HIV-1 has been published today in the open-access journal eLife.

3 Dec 2019

Failure in proteasome transportation system may cause neurodegenerative diseases

All neurodegenerative diseases have a common thread: the appearance of protein clumps in the brain such as amyloid-beta plaques in Alzheimer's disease and alpha synuclein aggregates in Parkinson's.

3 Dec 2019

New human colon-on-a-chip enables in vitro study of mucus physiology

We have a mutualistic but complicated relationship with the collection of microbes in our gut known as the intestinal microbiome.

3 Dec 2019

New treatment approach could improve outcomes for people with cystic fibrosis

A new approach to treating people with cystic fibrosis (CF) has been shown to reduce inflammation, which has the potential to reduce the need for lung transplants and lower the risk of death.

3 Dec 2019

Multiple mechanisms at work in diabetes drug metformin

Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels. In a collaborative effort, researchers from the Salk Institute, The Scripps Research Institute and Weill Cornell Medical College have used a novel technology to investigate why it functions so well.

3 Dec 2019

Roswell Park-led scientists identify new defense mechanism against prostate cancer

A research team led by a scientist at Roswell Park Comprehensive Cancer Center has identified the molecule LRIG1 as an important endogenous tumor suppressor in prostate cancer. Writing in the journal Nature Communications, the team documents their findings from preclinical studies showing that overexpression of the LRIG1 protein inhibits prostate cancer development, while reducing naturally occurring LRIG1 promotes prostate tumor development.

3 Dec 2019

Inhibition of a protease could improve the treatment of IBD, study shows

Scientists at the Centro Nacional de Investigaciones Cardiovasculares and the Centro de Investigaciones Biológicas of the Consejo Superior de Investigaciones Científicas have identified the protease MT1-MMP as a possible future target for drugs to treat inflammatory bowel disease.

3 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle.

3 Dec 2019

Researchers identify new drug target for treating neurological disorders

Understanding how the brain processes sweet, bitter and umami tastes may one day help researchers design more effective drugs for neurological disorders.

3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

New computational method can help predict and design allosteric functions in proteins

Called the "second secret of life", allostery is one of the most fundamental processes of biology and has been a central focus among scientists across the life sciences spectrum, from fundamental biology to drug development.

3 Dec 2019

Discovery could offer insight into different risk of diseases in African Americans

The percentage of African ancestry in a person's genome determines the level that certain genes are expressed, called mRNA, according to a new Northwestern Medicine study.

3 Dec 2019

Reducing STAT demand can improve patient care, suggests new study

While a lab test might be ordered STAT to help save a life, a new study suggests that the STAT test order should rest in peace, and instead the time standard for most clinical lab tests, like the commonly requested complete blood count, or CBC, should be more efficient.

3 Dec 2019

New findings regarding maintenance and functioning of the endosome

On a daily basis, multitudes of molecules enter each cell in our body. These can be nutrients or signal molecules or pathogenic microorganisms. An organelle in the cell directs these molecules to other stations for further processing.

3 Dec 2019

Researchers identify key protein required for therapeutic resistance in aggressive breast cancer

Researchers at the Lady Davis Institute have identified a key protein that is required for resistance to chemotherapy in the most aggressive form of breast cancer. This holds the promise of opening the door to new therapies for overcoming drug resistance.

2 Dec 2019

Protein C News and Research

New findings may help researchers leverage ERAP1 to fight cancer

Researchers identify mechanism for spread of HIV-1

Failure in proteasome transportation system may cause neurodegenerative diseases

New human colon-on-a-chip enables in vitro study of mucus physiology

New treatment approach could improve outcomes for people with cystic fibrosis

Multiple mechanisms at work in diabetes drug metformin

Roswell Park-led scientists identify new defense mechanism against prostate cancer

Inhibition of a protease could improve the treatment of IBD, study shows

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Researchers identify new drug target for treating neurological disorders

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

New computational method can help predict and design allosteric functions in proteins

Discovery could offer insight into different risk of diseases in African Americans

Reducing STAT demand can improve patient care, suggests new study

New findings regarding maintenance and functioning of the endosome

Researchers identify key protein required for therapeutic resistance in aggressive breast cancer

Blood proteins could help provide a comprehensive 'liquid health check' in future

Study suggests two new approaches against bone metastases from prostate cancer

Common clinical indicators of immune status and inflammation can predict mortality

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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