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G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

According to a study published in Blood, the Journal of the American Society of Hematology (ASH), researchers have reported that administration of granulocyte colony-stimulating factor (G-CSF), a drug that releases stem cells from the bone marrow into the blood, is unlikely to put healthy stem cell donors at risk for later development of abnormalities involving loss or gains of chromosomes that have been linked to hematologic disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia.

12 Aug 2011

Female sex hormone oestrogen could fight against cardiovascular disease

The sex hormone oestrogen could help protect women from cardiovascular disease by keeping the body's immune system in check, new research from Queen Mary, University of London has revealed.

12 Aug 2011

Researchers identify unknown link between migration of WBCs to infected tissues, immune memory

Researchers from Dr. Woodland's lab at the Trudeau Institute have now identified a previously unknown link between the migration of white blood cells to infected tissues and the ability of these cells to survive and become long-lived memory cells after the infection has been cleared.

11 Aug 2011

BCG vaccine can help immune system recognise cancer cells as 'foreign'

Scientists have found a potential new mechanism to stimulate the body's own ability to fight cancer using Baculillus Calmette-Guerin (BCG) - the germ commonly used to inoculate against tuberculosis.

11 Aug 2011

Scientists identify 29 new genetic variants linked to multiple sclerosis

Scientists have identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of a very debilitating neurological disease. Many of the genes -implicated in the study are relevant to the immune system, shedding light onto the immunological pathways that underlie the development of multiple sclerosis.

11 Aug 2011

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

New research led by Derya Unutmaz, MD associate professor, the Departments of Pathology, Medicine, and Microbiology at NYU School of Medicine and Mark Sundrud, PhD, of Tempero Pharmaceuticals, Inc., has identified a novel sensory pathway that modulates the potency of Th17 cell responses.

11 Aug 2011

Researchers team up to combat age-related macular degeneration

A professor at the University of California, Riverside Bourns College of Engineering has received a $100,000 grant to develop a new technique to fight a disease that gradually destroys vision.

8 Aug 2011

Researchers discover new tick-borne bacterium that causes ehrlichiosis in Wis., Minn.

A new tick-borne bacterium infecting humans with ehrlichiosis has been discovered in Wisconsin and Minnesota. It was identified as a new strain of bacteria through DNA testing conducted at Mayo Clinic.

4 Aug 2011

Hopkins stem cell research to examine how gene variants cause blood clotting disorders

4 Aug 2011

New insights into genesis and development of Sézary syndrome

Scientists at Charité - Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, the Max-Planck-Institut für Molekulare Genetik Berlin, and four other German institutes succeeded in proving a specific gene loss in a certain human lymphoma, the genesis of which is largely unexplained to date.

3 Aug 2011

Scientists look to create blood platelets from stem cells to study genetics of blood clotting disorders

Johns Hopkins scientists have launched a pioneering research program to create, for the first time, human platelet cells from stem cells in order to study inherited blood clotting abnormalities ranging from clots that cause heart attacks and stroke to bleeding disorders. The study is funded by a $9 million grant from the National Institutes of Health (NIH) as part of a nationwide initiative to examine how genetic variations cause heart, lung and blood diseases.

2 Aug 2011

Lack of TLR1 surface expression linked with increased susceptibility to tuberculosis

Are you genetically predisposed to tuberculosis? Scientists may now be able to answer this question and doctors may be able to adjust their therapeutic approach based on what they learn. That's because new research presented in the Journal of Leukocyte Biology suggests that two frequent mutations in an immune system gene called TLR1 are responsible for cellular changes that ultimately make us less likely to resist the disease.

2 Aug 2011

New liquid material shows promise for people with facial deformities

Biomedical engineers at Johns Hopkins have developed a new liquid material that in early experiments in rats and humans shows promise in restoring damaged soft tissue relatively safely and durably.

2 Aug 2011

UNOS policy change reduces disparities in kidney transplants for African-Americans

A national transplant policy change designed to give African-American patients greater access to donor kidneys has sliced in half the racial disparities that have long characterized the allocation of lifesaving organs, new Johns Hopkins research suggests.

2 Aug 2011

Myb protein suppression can help eliminate acute myelogenous leukemia

A team of scientists at Cold Spring Harbor Laboratory (CSHL) has laid bare the mechanism behind a phenomenon called oncogene addiction in mice suffering from a form of leukemia that mimics acute myelogenous leukemia (AML) in humans.

1 Aug 2011

UC San Diego receives NHLBI 'Program of Excellence in Glycosciences' grant

Scientists at the University of California, San Diego School of Medicine have received a major 7-year, $18 million grant to begin translating emerging discoveries in the field of glycosciences into new discoveries and therapies related to heart, lung and blood diseases.

26 Jul 2011

New WHO policy recommendation warns against use of blood tests for active TB

A new policy recommendation released on 20 July by the World Health Organization (WHO) warns against the use of serological (blood) tests to diagnose active tuberculosis.

25 Jul 2011

Microglia prune connections between neurons

Gardeners know that some trees require regular pruning: some of their branches have to be cut so that others can grow stronger. The same is true of the developing brain: cells called microglia prune the connections between neurons, shaping how the brain is wired, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, discovered.

22 Jul 2011

New rapid test accurately distinguishes bacterial and viral infections

Researchers at Ben-Gurion University of the Negev (BGU) have developed a new test that quickly and accurately distinguishes between bacterial and viral infections in as little as five hours.

21 Jul 2011

Possible new drug targets for treating diffuse large B-cell lymphoma

Researchers at the University of Maryland School of Medicine have discovered a novel interaction between two proteins involved in regulating cell growth that could provide possible new drug targets for treating diffuse large B-cell lymphoma, the most common type of non-Hodgkin's lymphoma.

20 Jul 2011

Leukocyte News and Research

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

Female sex hormone oestrogen could fight against cardiovascular disease

Researchers identify unknown link between migration of WBCs to infected tissues, immune memory

BCG vaccine can help immune system recognise cancer cells as 'foreign'

Scientists identify 29 new genetic variants linked to multiple sclerosis

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

Researchers team up to combat age-related macular degeneration

Researchers discover new tick-borne bacterium that causes ehrlichiosis in Wis., Minn.

Hopkins stem cell research to examine how gene variants cause blood clotting disorders

New insights into genesis and development of Sézary syndrome

Scientists look to create blood platelets from stem cells to study genetics of blood clotting disorders

Lack of TLR1 surface expression linked with increased susceptibility to tuberculosis

New liquid material shows promise for people with facial deformities

UNOS policy change reduces disparities in kidney transplants for African-Americans

Myb protein suppression can help eliminate acute myelogenous leukemia

UC San Diego receives NHLBI 'Program of Excellence in Glycosciences' grant

New WHO policy recommendation warns against use of blood tests for active TB

Microglia prune connections between neurons

New rapid test accurately distinguishes bacterial and viral infections

Possible new drug targets for treating diffuse large B-cell lymphoma

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