Protein C News and Research

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DNA sequences encode information in many different ways

DNA sequences encode information in many different ways. Codons specify the amino acids involved in making a protein.

30 Oct 2019

Bortezomib drug helps re-balance disrupted muscle growth, prevent contractures

When children experience brachial plexus injury at birth, or are born with cerebral palsy, some of the most disabling problems that follow are muscle contractures, or tightness of muscles, that severely restrict limb function.

29 Oct 2019

First effective noninvasive method for diagnosing early-stage liver diseases

A safer and more sensitive contrast dye for MRI tests developed by a team led by Georgia State University researchers may provide the first effective, noninvasive method for detecting and diagnosing early-stage liver diseases, including liver fibrosis.

29 Oct 2019

Patterns of Alzheimer's-related damage differ by subtype and age of onset, study finds

Despite decades of scientific scrutiny, Alzheimer's disease researchers have yet to work out its cause or treatment. Understanding what underlies its three distinct subtypes is thought to be a promising new research avenue.

29 Oct 2019

IDIBELL researchers identify involvement of cell membrane protein in liver cancer

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have just described for the first time the crucial involvement of a cell membrane protein in the development and progression of liver cancer, according to an article published in the Journal of Hepatology.

29 Oct 2019

Wisconsin study: 3 in 5 people with Down syndrome diagnosed with dementia by age 55

Not so many years ago, people with Down syndrome rarely survived to middle age. Many died young due to heart problems associated with the congenital condition.

29 Oct 2019

Dynamic molecular signaling waves control embryonic fates

Timing is everything for young cells waiting to determine their identities.

29 Oct 2019

Scientists solve first structure of human cotransporter protein KCC1

In work that could someday improve treatments for epilepsy, UT Southwestern scientists have published the first three-dimensional structure of a member of a large family of human proteins that carry charged particles – ions – across the cell membrane.

29 Oct 2019

Study uses whole-genome sequencing for early identification and containment of AMR pathogens

A study published today in PNAS examines the evolutionary and epidemiologic history of an epidemic strain of extensively drug-resistant tuberculosis (XDR-TB) - called LAM4/KZN- in KwaZulu-Natal, South Africa.

29 Oct 2019

Rice scientists take a step toward simplifying drug manufacture

With a lot of hard work and a dash of salt, Rice University scientists have taken a step toward simplifying drug manufacture.

29 Oct 2019

Researchers reconstruct the evolutionary history of metabolism

By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks - which drive every cellular process from protein building to DNA repair - became less random, more modular and more hierarchical over time, the researchers say.

29 Oct 2019

NEOMED professor receives DOD grant to explore if exercise proves to be neuroprotective

Sheila Fleming, Ph.D., an assistant professor of pharmaceutical sciences at Northeast Ohio Medical University, was recently awarded a three-year, $954,566 grant by the U.S. Army Medical Research Acquisition Activity for the project titled, "Exercise Effects on Synuclein Aggregation, Neuroinflammation, and Neurodegeneration."

29 Oct 2019

Pro-inflammatory protein could play key role in protecting against herpes virus

Researchers at the University of Arizona College of Medicine - Phoenix have discovered a function in a pro-inflammatory protein that could play an important part in improving current and future therapeutics for the herpes virus.

29 Oct 2019

Novel antibodies could provide a universal flu vaccine

Now, a new study published in the journal Science on October 25, 2019, reports on a set of three novel antibodies that bind to another type of viral cell surface antigen called neuraminidase (NA) that is necessary for viral replication.

28 Oct 2019

Discovery of causal link between hydrogen sulfide and schizophrenia

Researchers from the RIKEN Center for Brain Science in Japan have found certain chemical markers that are associated with schizophrenia. They worked with lab mice with models of schizophrenia as well as post mortem brain specimens of persons with schizophrenia. The study titled, “Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology,” was published in the latest issue of the journal EMBO Molecular Medicine.

28 Oct 2019

Some types of proteins can stabilize damaged DNA

At the University of Copenhagen, researchers have discovered how some types of proteins stabilize damaged DNA and thereby preserve DNA function and integrity. This new finding also explains why people with inborn or acquired defects in certain proteins cannot keep their DNA stable and develop diseases such as cancer.

28 Oct 2019

MPST enzyme levels in hair could be a good biomarker for schizophrenia

Working with model mice, post-mortem human brains, and people with schizophrenia, researchers at the RIKEN Center for Brain Science in Japan have discovered that a subtype of schizophrenia is related to abnormally high levels hydrogen sulfide in the brain.

28 Oct 2019

New cystic fibrosis drug now available through NHS England

On October 24, 2019, cystic fibrosis (CF) patients rejoiced at the news that three years of talks between the UK’s National Institute for Health and Care Excellence (NICE) and Vertex Pharmaceuticals had succeeded in a compromise which could see about 5,000 patients gaining access to a potentially life-saving drug called Orkambi within the next month. Orkambi is perceived to be a ‘wonder drug’ because it helps these patients to breathe easier and better, and can be started as young as two years.

28 Oct 2019

How the SETD1A gene produces schizophrenia in mice

A new study published in the journal Neuron on October 9, 2019 reports that scientists have unlocked part of the secrets of the SETD1A gene – how mutations in the gene put the individual at risk for the condition.

26 Oct 2019

New cellular immunotherapy for cancers

A new study published in the journal Nature Communications on 22 October 2019 reports a new approach to cancer treatment that increases the immune capability of T lymphocytes against malignant cancers. This allows the T cells to successfully infiltrate and destroy these tumors. Animal trials have been completed and the researchers are planning clinical trials in human beings next.

26 Oct 2019