Endometrium News and Research

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Review outlines key strategies to reduce gynecologic cancer-related mortality

Low- and middle-income countries (LMICs) bear a disproportionate burden of gynecologic malignancies-cancers of the cervix, endometrium, ovary, vagina, and vulva.

24 Aug 2026

Phase 3 clinical trial enrolls first platinum-resistant ovarian cancer patient

The GOG Foundation, Inc. is proud to announce the enrollment of the first patient in GOG-3132/BEHOLD-Ovarian01 (NCT07286266), a global Phase 3 clinical trial titled A Randomized, Open-label, Multicenter, Phase 3 Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants with Platinum-resistant Ovarian Cancer.

27 Jul 2026

Endometriosis affects multiple body systems beyond pelvic pain

Migraines, digestive problems, anxiety, and depression can be part of endometriosis, although they are often interpreted as separate conditions.

16 Jul 2026

Uterine aging may reduce donor egg pregnancy success after 49

A major new study suggests that age-related changes in the uterus may contribute to poorer pregnancy outcomes, with women aged 49 and over experiencing lower live birth rates and higher miscarriage risk despite donor-oocyte treatment.

5 Jul 2026

AI imaging technique detects early endometrial cancer with high accuracy

Endometrial cancer is the most common gynecologic cancer, with more than 69,000 cases diagnosed in the U.S. in 2025 and increasing up to 3% annually.

18 Jun 2026

Adult weight gain strongly linked to higher obesity-related cancer risk

New research presented at this year's European Congress on Obesity (ECO 2026) in Istanbul, Turkey (12-15 May) shows that people who gain the highest amount of weight across adulthood are at greatly increased risk of certain obesity related cancers.

13 May 2026

Sustained high progesterone during pregnancy can improve menstrual cyclicity in PCOS patients

Polycystic ovary syndrome (PCOS) affects 6%−20% of reproductive-aged women, and is commonly accompanied by irregular menstrual cycles and anovulatory infertility.

11 Feb 2026

Natural ovulation offers a safer path to IVF success

Researchers compare the effects of natural ovulation and external hormone replacement regimens for preparing the uterus before frozen embryo transfer.

4 Feb 2026

PFOA exposure disrupts hormone signaling and impairs embryo implantation in mice

A new experimental study has found that perfluorooctanoic acid (PFOA), a widely used industrial chemical, can interfere with key biological processes required for successful embryo implantation, raising concerns about its potential impact on female fertility.

27 Jan 2026

Targeted uterine mRNA treatment boosts fertility outcomes in mice

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine - which designs nanotechnology-based platforms for clinical translation across specialties - developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.

22 Jan 2026

Natural ovulation matches hormone therapy success in frozen embryo transfer

Natural ovulation before frozen embryo transfer is as effective as hormone treatment for achieving a healthy baby by vitro fertilization (IVF), finds a clinical trial from China published by The BMJ today.

21 Jan 2026

Endometrium-free closure technique for C-section may help lower the risk of long-term complications

As cesarean delivery (C-section) rates continue to rise worldwide, experts at NYU Langone Health are highlighting a surgical technique that may help lower the risk of long-term complications.

2 Jan 2026

Engineered womb lining model opens a window into embryo implantation

By engineering a system replicating the womb lining with high biological accuracy, researchers at the Babraham Institute and Stanford University have been able to study the implantation of human embryos, opening up this enigmatic process to investigation.

23 Dec 2025

Early embryos and the uterus engage in active communication during implantation

A new study shows that the embryo and the uterine lining conduct an active "conversation" from the very earliest stages of implantation. They engage in a back and forth of tiny packages called extracellular vesicles and lipid droplets, which carry metabolites and signals.

17 Dec 2025

Influenza infection in pregnant mice linked to fetal brain exposure

A new study from the University of Illinois Urbana-Champaign shows, for the first time, that severe flu infection in pregnant mice leads to a breakdown in placental and brain barriers, leading to the accumulation of potentially harmful molecules in the fetal brain.

24 Sep 2025

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – from acne and psoriasis, to rheumatoid arthritis and inflammatory bowel disease.

24 Sep 2025

Study reveals bidirectional relationship between long COVID and menstrual disorders

Women suffering from long COVID have a greater risk of experiencing abnormal uterine bleeding.

18 Sep 2025

Long COVID linked to heavier periods and symptom flare-ups during menstruation

Researchers found that long COVID is linked to heavier, longer, and more irregular bleeding without disrupting ovulation. Symptom severity also peaks around menstruation, likely driven by hormonal and immune changes.

17 Sep 2025

Elinzanetant reduces hot flashes in menopause

The OASIS-3 trial demonstrates elinzanetant's effectiveness in alleviating menopausal symptoms, reducing hot flashes significantly over a year-long study.

11 Sep 2025

New technique succeeds in studying embryo implantation outside the body

The use of assisted reproductive technologies like in vitro fertilization is becoming more common worldwide. However, while these technologies successfully create viable embryos, a little over half of all embryos are lost because they fail to implant into the uterus.

2 Sep 2025