Endothelin News and Research

RSS

Endothelins are proteins that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.

Review reveals how nicotine damages blood vessels and heart health

A review published today in Nature Reviews Cardiology provides the most detailed picture yet of how nicotine damages the cardiovascular system – tracing the biological chain of events from the moment nicotine binds to receptors in blood vessel walls through to the atherosclerotic plaque rupture that triggers heart attacks and strokes.

19 Aug 2026

Understanding post-traumatic vasospasm as a hidden complication of traumatic brain injury

A new review published in the Journal of Intensive Medicine on 25 July, 2025 and led by Dr. Alice Jacquens and Dr. Clara Perrault from Pitié Salpêtrière Hospital, Paris, France, sheds light on an under-recognized complication of traumatic brain injury (TBI): post-traumatic vasospasm (PTV).

17 Oct 2025

Erythritol alters brain vessel function and may raise stroke risk

Study shows erythritol adversely affects brain microvascular cells, increasing oxidative stress and impairing nitric oxide production, linked to stroke risk.

21 Jul 2025

Popular sugar substitute could raise the risk of blood clots and stroke

From low-carb ice cream to keto protein bars to "sugar-free" soda, the decades-old sweetener erythritol is everywhere.

14 Jul 2025

Plant-based diets may help prevent erectile dysfunction

A narrative review in The Journal of Nutrition suggests that whole-food plant diets may help prevent or improve erectile dysfunction (ED) by supporting vascular health and reducing risk factors such as LDL cholesterol and inflammation. However, most evidence is observational, and more clinical trials are needed.

25 Jun 2025

Heavy smoking triggers systemic inflammation and vascular damage in new biomarker study

Heavy smoking in adult males significantly increases oxidative stress, inflammation, and vascular dysfunction, as shown by comprehensive blood and tissue biomarker analysis. The findings highlight measurable biological damage and reinforce the urgent need for targeted public health interventions.

26 May 2025

Macrophages take center stage in liver healing after injury

The liver is famous for its remarkable ability to regenerate, but that healing power depends heavily on the actions of its resident immune cells. A new study spotlights macrophages, the liver's cleanup and repair specialists, revealing that these cells quickly adapt after injury to clear debris and support tissue recovery.

7 May 2025

How gut health shapes heart disease risk — and what you can do about it

A new review highlights how gut microbiome imbalances contribute to cardiovascular disease by altering short-chain fatty acids, TMAO, and inflammatory pathways. The study emphasizes the potential of prebiotics, probiotics, and dietary changes to restore gut health and reduce heart disease risk.

13 Mar 2025

A step toward precision medicine: New drug targets for heart failure

Researchers identify several promising drug targets for heart failure and its clinical subtypes.

14 Feb 2025

Circadian chaos: How transportation noise harms heart health

Transportation noise poses serious risks to cardiovascular health, causing inflammation, oxidative stress, and circadian rhythm disruption, with compounded effects from air pollution.

12 Dec 2024

Cherries and berries: Nature’s sweet remedy for a healthy heart

Research paper reviews the cardiovascular benefits of phenolic compounds in cherries and berries, highlighting their potential to reduce inflammation, oxidative stress, and improve lipid profiles. Regular consumption of these fruits can significantly lower the risk of cardiovascular diseases.

23 May 2024

Space travel alters human vascular cell function, study finds

Study investigates the transcriptomic changes in human vascular smooth muscle cells exposed to spaceflight, revealing significant alterations in gene expression affecting cellular function and phenotype.

31 Mar 2024

New genetic links to coronary artery calcification uncovered, offering treatment insights

A study in Nature Cardiovascular Research identifies two new genetic loci associated with coronary artery calcification (CAC), a key indicator of atherosclerosis and coronary artery disease.

5 Dec 2023

High-impact clinical trial results to be presented at ASN Kidney Week 2023

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2023 November 1–November 5.

3 Nov 2023

What are the effects of smoking cessation on vascular endothelial function?

The effects of smoking cessation on vascular endothelial function.

16 Oct 2023

Is there a correlation between acute and chronic red wine intake and health?

Researchers examined the correlations between acute and chronic red wine (RW) intake and health.

18 Apr 2023

Antioxidant-rich phenolic compounds: A key to disease prevention, gut health, and brain homeostasis

Researchers report on the benefits of consuming dietary phenols and their relationship with the intestinal microbiome.

10 Apr 2023

Association between cardiovascular disease and transportation noise revealed in new research

Researchers assessed the association between cardiovascular disease and transportation noise.

3 Mar 2023

Common kidney disease could be treated with existing medicines, new study shows

A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows.

14 Dec 2022

Exploring SARS-CoV-2-associated endothelial dysfunction

A new study described the evidence, mechanisms, and therapies for endothelial dysfunction in coronavirus disease 2019 (COVID-19).

21 Oct 2022