Exhaustion News and Research

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Protein DUSP4 prevents immune cell exhaustion in colorectal cancer

The immune system has powerful cells that can recognize and destroy cancer, but this ability can gradually wane when the cells reside within a tumor.

4 Nov 2026

Tree shade protects unsheltered homeless people from dangerous urban heat

People experiencing unsheltered homelessness in Salt Lake City face hours of dangerous daytime heat and hot nights that offer little relief, according to a University of Utah study.

3 Nov 2026

Excessive exercise disrupts dopamine regulation in the brain, study finds

Excessive physical exercise affects more than just the muscles; it can also alter brain chemistry. A new study published in the journal Neuroscience revealed that exhaustive training without adequate rest alters the regulation of dopamine in the hippocampus, a brain region closely linked to memory and the regulation of emotions.

30 Oct 2026

Targeting ANO6 protein weakens pancreatic cancer and boosts immunity

Fox Chase Cancer Center researchers identified a potential therapeutic target for pancreatic cancer after showing that tumor growth can be slowed and immune suppression can be reduced in preclinical trials by blocking a particular protein, called anoctamin 6 (ANO6).

30 Oct 2026

Researchers find simple way to boost engineered T-cell therapies

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a promising new strategy to make cancer-fighting immune cells stronger and potentially longer-lasting, a discovery that could help improve the effectiveness of immunotherapies that use a patient's own immune cells to attack cancer.

29 Oct 2026

New study reveals why college athletes experience severe burnout

As both athletes and students, college athletes face a lot of pressure. In fact, the NCAA Student-Athlete Health and Wellness Study (2023) found that 16-35% of athletes felt mentally exhausted most days.

29 Oct 2026

Australian study highlights delayed diagnosis in postpartum psychosis care

Women with postpartum psychosis are making repeated pleas for help before receiving a diagnosis, with the first Australian study of their help-seeking experiences finding many contacted health services an average of seven times before getting the care they needed.

22 Oct 2026

Most frail breast cancer survivors lack Medicare home care

For the increasing number of women that survive breast cancer, many older, long-term survivors remain frail. A new study out today in the Journal of the National Cancer Institute shows that in a given year over half of these highly frail survivors had no Medicare home health care.

20 Oct 2026

Extreme heat threatens maternal health and newborn wellbeing worldwide

Extreme heat has led to a marked increase in the risks faced by pregnant women and their babies, according to a survey of 1,000 healthcare professionals in countries including Brazil, India and Zimbabwe.

11 Oct 2026

Combination therapy overcomes immunotherapy resistance in glioblastoma

Scientists at The Wistar Institute have identified a combination treatment that overcomes two of the biggest barriers to immunotherapy in glioblastoma.

8 Oct 2026

Review highlights emerging treatments for glioblastoma multiforme

A new research perspective was published in Volume 13 of Oncoscience on September 17, 2026, titled "Emerging pharmacological agents for glioblastoma multiforme: An update on active clinical trials (2025–2026)."

25 Sep 2026

In vivo CAR-T therapy transforms customized treatments into universal medicines

A collaborative team led by Professor Huji Xu from Naval Medical University, China, together with Professors Xuanming Yang and Yujia Cai at Shanghai Jiao Tong University, China, published a comprehensive review in Volume 2, article number 33 of the journal Immunity & Inflammation on August 31, 2026.

25 Sep 2026

Clinicians' words hold power to heal or harm patients

Dr. Wendy Harpham was 36 years old and a successful physician who prided herself on her empathy. Then she was diagnosed with cancer.

21 Sep 2026

Young onset dementia creates years of uncertainty for families

Families caring for a loved one with young onset dementia are facing years of uncertainty, financial strain and emotional exhaustion - with many struggling to access timely diagnosis and appropriate support, according to a new Curtin University study.

16 Sep 2026

Vitamin A derivative prevents immune cell exhaustion in brain tumors

Immune cells can become exhausted after prolonged exposure to cancer, gradually losing their ability to attack tumor cells.

8 Sep 2026

Advancing intracellular delivery with LumiPore®: A new approach to cell transfection and drug discovery

Discover how LumiPore improves intracellular delivery with gentle, high-efficiency transfection for drug discovery and cell therapy research.

From Trince 8 Sep 2026

Shared biological pathways may explain chronic fatigue across diseases

A shared biological secret that helps explain chronic exhaustion in conditions including long Covid and PTSD has been discovered by researchers at the University of East Anglia and Oxford BioDynamics.

2 Sep 2026

Antiviral COVID-19 drug shows no benefit for Long COVID

Results from a clinical trial funded by the National Institutes of Health (NIH) and published today in the journal Lancet Infectious Diseases show that the antiviral drug, PAXLOVID, commonly prescribed to treat acute COVID-19, does not have an impact on Long COVID symptoms when compared to placebo.

1 Sep 2026

Extreme heat exposure triggers broad range of medical emergencies

When temperatures spike, emergency physicians expect to see more cases of dehydration and heat stroke.

27 Aug 2026

A striking immune cell pattern emerges around a person’s 100th birthday

Single-cell immune profiling found that CD4 cytotoxic T lymphocytes become more abundant around age 100, showing stepwise differentiation and substantial clonal expansion. Ex vivo experiments also revealed cytokine plasticity within individual clones, supporting the hypothesis that these cells adapt to persistent antigens during healthy aging, although their direct role in longevity remains unproven.

23 Aug 2026