Exhaustion News and Research

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Shared biological pathways may explain chronic fatigue across diseases

A shared biological secret that helps explain chronic exhaustion in conditions including long Covid and PTSD has been discovered by researchers at the University of East Anglia and Oxford BioDynamics.

2 Sep 2026

Antiviral COVID-19 drug shows no benefit for Long COVID

Results from a clinical trial funded by the National Institutes of Health (NIH) and published today in the journal Lancet Infectious Diseases show that the antiviral drug, PAXLOVID, commonly prescribed to treat acute COVID-19, does not have an impact on Long COVID symptoms when compared to placebo.

1 Sep 2026

Extreme heat exposure triggers broad range of medical emergencies

When temperatures spike, emergency physicians expect to see more cases of dehydration and heat stroke.

27 Aug 2026

A striking immune cell pattern emerges around a person’s 100th birthday

Single-cell immune profiling found that CD4 cytotoxic T lymphocytes become more abundant around age 100, showing stepwise differentiation and substantial clonal expansion. Ex vivo experiments also revealed cytokine plasticity within individual clones, supporting the hypothesis that these cells adapt to persistent antigens during healthy aging, although their direct role in longevity remains unproven.

23 Aug 2026

Digital program reduces anxiety and depression in adults with chronic medical conditions

A digital program combining guided movement, breathing and meditation exercises, and coping-skills training reduced anxiety and depression symptoms in adults with chronic medical conditions, according to a new study published August 20th in the open access journal PLOS Medicine by Puneeta Tandon of the University of Alberta, Canada, and colleagues.

20 Aug 2026

Glioma microenvironment emerges as key target for future therapies

The prognosis for glioma patients remains extremely poor despite aggressive multimodal standard therapy: maximal safe resection, radiotherapy, and temozolomide chemotherapy, with median survival rarely exceeding 15 to 18 months.

20 Aug 2026

Exhausted T cells can escape tumors and confer long-lasting immunity to cancer in mice

As the immune system battles cancer, chronic stimulation gradually drives T cells to a state of exhaustion.

18 Aug 2026

Engineered immune cells help eliminate severe bacterial infections effectively

Severe bacterial infections remain a major global health challenge because antibiotics alone often fail when the host immune system becomes dysfunctional.

17 Aug 2026

Intracranial local field potentials offer clues to prolonged disorders of consciousness

Prolonged disorders of consciousness (pDOC) represent states in which patients fail to show reliable evidence of awareness after severe brain injury.

16 Aug 2026

Exhausted T cells balance graft tolerance and infection risk

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

7 Aug 2026

New review links obesity with accelerated biological aging mechanisms

The global rise in obesity and population aging represents a major public health challenge, with growing evidence suggesting that excess body fat not only increases the risk of chronic disease but may also accelerate the biological aging process.

6 Aug 2026

Digital care app improves quality of life for breast cancer patients

Regularly checking in with patients with metastatic breast cancer by way of an app to enquire about their well-being – and responding promptly – can alleviate their debilitating fatigue and make their daily lives easier.

6 Aug 2026

Physical activity linked to lower stroke and death risk in adults with atrial fibrillation

Being physically active was linked to a lower risk of stroke and death for adults with atrial fibrillation, or AFib, according to new, independent research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

5 Aug 2026