Glycosylation News and Research

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Greenwood Genetic Center researcher wins major grant to explore cellular metabolism and glycosylation

Heather Flanagan-Steet, PhD, Associate Director of Research at the Greenwood Genetic Center (GGC), has received a $1.4 million, five-year Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institutes of Health's National Institute of General Medical Sciences.

21 Oct 2026

New study investigates PFAS exposure and future inflammatory bowel disease

Exposure to per- and polyfluoroalkyl substances (PFAS), often called "forever chemicals," may play a role in the development of inflammatory bowel disease (IBD) years before symptoms appear, according to a new five-year study supported by a $3.3 million National Institutes of Health (NIH) R01 grant to researchers at the Icahn School of Medicine at Mount Sinai.

5 Oct 2026

$5.7 million NIH grant supports research on why lean people develop insulin resistance

A Wayne State University research team was awarded a $5.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health focused on discovering the biological mechanisms that may help explain why some lean people develop insulin resistance while some people with obesity remain sensitive to insulin.

29 Sep 2026

An approved Ebola antibody may miss its mark against Bundibugyo virus

Researchers analyzed 44 Bundibugyo virus genomes and modeled how approved and experimental Ebola antibodies might bind the virus’s glycoprotein. The models predicted disrupted binding for Ebanga, conserved targets for MBP134, and different binding behavior for the complete Inmazeb cocktail than for two of its antibodies alone; laboratory tests are needed to determine whether these findings translate into treatment benefit.

28 Sep 2026

Toxoplasma remodels host cell surfaces to trigger invasion

At first, cholesterol and glycosylation seemed like two separate leads. As the researchers followed them, however, the pathways converged.

25 Sep 2026

Long-acting HIV prevention tools could help close the gap before a vaccine arrives

A review of non-vaccine HIV interventions highlights the strong preventive effects of long-acting PrEP, sustained ART, U=U, vertical transmission programs, and voluntary medical male circumcision. Gene editing and multispecific antibodies may expand future options, but safety, cost, access, adherence, and implementation barriers remain.

5 Aug 2026

Scientists develop a promising way to create new antifungal drug candidates

Scientists at Imperial College London and The University of Manchester have developed a promising new way to create safer and more effective treatments for life-threatening fungal infections.

29 Jul 2026

Researchers identify key barrier preventing self repair of heart cells

Specialized cells in our body make biological tradeoffs to do certain jobs. To support large and hardworking hearts that power our other organs, our heart cells evolved to be extremely efficient and resilient.

28 Jul 2026

Scientists uncover new molecular mechanism driving gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract, with KIT mutations driving approximately 75% to 80% of cases.

23 Jun 2026

Researchers map rare DHDDS disease mechanism using lab-grown mini brains

Variants in the DHDDS gene cause a severe neurodegenerative condition, characterized by tremors, seizures, coordination and learning difficulties, usually manifesting in early childhood. This Parkinson's-like condition is extremely rare, and until recently, parents were told that there was nothing that could be done to slow down its progression.

15 Jun 2026

Glucosamine may worsen Alzheimer’s by fueling abnormal brain glycosylation

A Nature Metabolism study identifies brain hyperglycosylation as a metabolic driver of Alzheimer’s disease, with increased N-glycan biosynthesis seen in human AD tissue and mouse models. Reducing glycosylation improved memory in AD mice, while glucosamine worsened memory deficits in 5xFAD mice and was associated with poorer outcomes in dementia patients.

14 Jun 2026

New study frames altered protein modifications as cancer drivers

Cancer has often been explained through mutations in deoxyribonucleic acid (DNA) or changes in ribonucleic acid (RNA), but these layers do not fully explain why tumors with similar genetic profiles can behave differently.

9 Jun 2026

New computational pipeline improves effectiveness of pan-Ebola neutralizing antibodies

A team led by Professor Wei Yang at the National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, has developed a computational-experimental pipeline that synergistically optimizes antibody framework regions (FR) and complementarity-determining regions (CDR).

24 May 2026

New non invasive way to diagnose childhood epilepsy through blood sugar patterns

A study published in Engineering has demonstrated that the N-glycome of serum-derived extracellular vesicles (EVs) can serve as a non-invasive biosignature for the diagnosis and classification of childhood epilepsy, offering a new tool for precision and longitudinal monitoring in clinical settings.

14 May 2026