Heart Transplantation News and Research

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A heart transplant is an operation in which the diseased heart in a person is replaced with a healthy heart from a deceased donor. Ninety percent of heart transplants are performed on patients with end-stage heart failure.

Heart failure is a condition in which the heart is damaged or weakened and can't pump enough blood to meet the body's needs. "End-stage" means the condition has become so severe that all treatments, other than heart transplant, have failed.

H-ISDN shows no significant benefit in broader heart failure population

In patients with heart failure, hydralazine with isosorbide dinitrate did not significantly improve the incidence of death or heart failure events and treatment discontinuation rates were high.

30 Aug 2026

Molecular mapping reveals hidden cellular programs in heart transplant rejection

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

12 Aug 2026

New research agreement funds xenoliver transplant center at Baylor

Baylor College of Medicine today announced that a new research agreement with United Therapeutics Corporation, a public benefit corporation, will provide up to $5 million a year for five years to establish the Baylor College of Medicine Center for Xenoliver Transplantation and Immunomodulation (XTI), dedicated to advancing scientific understanding of xenoliver transplantation.

10 Aug 2026

Spatial transcriptomics study elucidates cellular dynamics during heart transplant rejection

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

10 Aug 2026

Medical breakthrough allows kidney transplant for patient with zero options

An international research team led by the Medical University of Vienna reports on a new treatment strategy that has made a kidney transplant possible for a patient with no realistic chance of receiving a suitable donor organ.

30 Jul 2026

Organ transplant survival rates improve despite persistent donor shortages

More adults are surviving both the wait for an organ and transplant surgery, but the number of people who need transplants continues to exceed the number of organs available, especially for kidneys, according to a national analysis published in the Journal of the American College of Surgeons (JACS).

4 Jun 2026

American Heart Association launches national heart transplant research network

Nearly 60 years after the first successful heart transplant, the American Heart Association, a relentless force changing the future of health for everyone everywhere, is launching a bold new initiative to fundamentally transform how heart transplant care is delivered across the United States - addressing long-standing gaps in innovation, equity and patient outcomes.

3 Jun 2026

New model improves outcome predictions for patients with hypertrophic cardiomyopathy

Findings from a study supported in part by the National Institutes of Health (NIH) have identified a new model for predicting outcomes for hypertrophic cardiomyopathy (HCM), a heart condition with a prevalence of 1 in 500 people and a frequent cause of sudden cardiac death.

11 May 2026

Experts debate benefits and costs of robotic lung transplantation

The expanding use of robotic technology in lung transplantation came under scrutiny at today's 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), where experts debated whether its clinical benefits justify the cost and complexity.

25 Apr 2026

Pediatric heart transplant demand rises amid severe donor shortage

Advances in pediatric heart care are helping more children survive long enough to receive a transplant-but a critical shortage of donor hearts means too many are still dying while they wait, experts warned today at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.

25 Apr 2026

Global debate continues over fair allocation of donor hearts

As demand for heart transplants continues to far exceed the number of available donor hearts, experts at today's 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) explored a critical question: how should this scarce, life-saving resource be allocated?

25 Apr 2026

"Domino" heart valves from diseased organs could save thousands of children

A surgical innovation called partial heart transplantation could transform care for children with severe heart valve disease, allowing for thousands of additional valve transplants each year, according to a presentation delivered today by Joseph Turek, MD, PhD, at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.

24 Apr 2026

Cleveland Clinic expert proposes global heart allocation to address health inequities

Today at the 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Eileen Hsich, MD, of the Cleveland Clinic, outlined a bold vision for the future of heart transplantation that moves beyond national borders to address global inequities in organ allocation.

22 Apr 2026

Disrupted lymphatic vessels may drive chronic organ transplant rejection

Despite advances in the field of organ transplantation, long-term organ rejection that can become apparent a decade or more after a heart or lung transplant remains a common problem for patients.

25 Feb 2026

New model predicts redo surgery risk in adult congenital heart disease

Heart specialists at Mayo Clinic today presented new research at the 2026 Society of Thoracic Surgeons Annual Meeting that redo surgery for adults with congenital heart disease (CHD) remains high-risk, and a clinically applicable national risk assessment model is needed to help patients and care teams make decisions about procedures.

31 Jan 2026

Current state, challenges, and future directions of heart transplantation in USA and Western Europe

In nearly 60 years, heart transplantation has transformed from a daring vision to an established surgical procedure. Since the first adult heart transplant in the United States was performed at Stanford Hospital in 1968, the field has made significant strides.

4 Dec 2025

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

Study reveals how type 2 diabetes directly alters the heart’s structure and energy systems

A new study from the University of Sydney has revealed how type 2 diabetes directly alters the heart’s structure and energy systems, offering vital insights into why people with diabetes are at greater risk of heart failure.

2 Sep 2025

New ESC guidelines prioritize women's autonomy in high-risk pregnancies

Updated ESC Guidelines, published today at ESC Congress 2025, put a focus on a woman's autonomy in making her own reproductive choices by promoting a transparent dialogue and shared decision-making for pregnancies that are high-risk for an adverse maternal and/or fetal event.

30 Aug 2025

Study identifies risk factors that increase risk of death in children with Fontan circulatory failure

A multi-center study has identified critical risk factors that increase the likelihood of death in children with a heart defect who are awaiting or have recently undergone heart transplantation, according to findings published in Circulation.

11 Aug 2025

Heart Transplantation News and Research

H-ISDN shows no significant benefit in broader heart failure population

Molecular mapping reveals hidden cellular programs in heart transplant rejection

New research agreement funds xenoliver transplant center at Baylor

Spatial transcriptomics study elucidates cellular dynamics during heart transplant rejection

Medical breakthrough allows kidney transplant for patient with zero options

Organ transplant survival rates improve despite persistent donor shortages

American Heart Association launches national heart transplant research network

New model improves outcome predictions for patients with hypertrophic cardiomyopathy

Experts debate benefits and costs of robotic lung transplantation

Pediatric heart transplant demand rises amid severe donor shortage

Global debate continues over fair allocation of donor hearts

"Domino" heart valves from diseased organs could save thousands of children

Cleveland Clinic expert proposes global heart allocation to address health inequities

Disrupted lymphatic vessels may drive chronic organ transplant rejection

New model predicts redo surgery risk in adult congenital heart disease

Current state, challenges, and future directions of heart transplantation in USA and Western Europe

Advances in diagnosis and management of systemic light chain amyloidosis

Study reveals how type 2 diabetes directly alters the heart’s structure and energy systems

New ESC guidelines prioritize women's autonomy in high-risk pregnancies

Study identifies risk factors that increase risk of death in children with Fontan circulatory failure

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