Hypoplastic News and Research

RSS

Children’s Hospital Colorado completes its first heart and liver dual transplant

Children's Hospital Colorado (Children's Colorado) successfully performed the hospital's first-ever heart and liver dual organ transplant, with support from dozens of team members across 25 different multidisciplinary care teams.

19 Dec 2025

Inflammatory cells drive lung underdevelopment in congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) is a dangerous malformation of the lungs and diaphragm that causes almost a third of affected babies to die from underdeveloped lungs. So far, there have been no concrete options for treating this malformation with medication.

22 Sep 2025

New method expands access to patient-specific amniotic stem cells

Researchers at the University of Colorado Anschutz Medical Campus have discovered that amniotic fluid stem cells can be safely collected from vaginal fluid after childbirth rather than relying on more invasive methods that can pose some risk to the mother and fetus.

16 Jul 2025

Neanderthal child with Down syndrome reveals ancient caregiving practices

Research reveals that Neanderthals provided extensive caregiving, allowing a child with Down syndrome and congenital ear pathology to survive for at least six years, highlighting their complex social structures.

1 Jul 2024

Progesterone therapy shows mixed results for neurodevelopment in infants with heart defects

A randomized clinical trial published in JAMA Network Open found no significant overall benefit of maternal progesterone therapy on neurodevelopmental outcomes in infants with congenital heart defects, but observed improvements in female children and specific heart conditions.

2 Jun 2024

Injectable hydrogel can mitigate right ventricular heart failure

An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journal of the American College of Cardiology: Basic to Translational Science.

6 Mar 2024

Single-ventricle physiology correlates with higher short-term mortality among adult congenital heart disease transplant recipients

UCLA-led research finds that among adult congenital heart disease (CHD) transplant recipients, single-ventricle physiology correlated with higher short-term mortality.

12 Sep 2023

Researchers find new genes that contribute to hypoplastic left heart syndrome

By identifying genes in patients and testing their effects in fruit flies, researchers from Sanford Burnham Prebys have found new genes that contribute to hypoplastic left heart syndrome (HLHS), a rare, life-threatening heart disease that occurs in infants.

17 Jul 2023

Research shows redlining's long-term impact on cardiovascular health of Black adults

The risk of heart failure in the present day was higher among Black adults who lived in U.S. zip codes historically impacted by redlining, according to research published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

17 Jul 2023

Shattered dreams and bills in the millions: Losing a baby in America

The day after his 8-month-old baby died, Kingsley Raspe opened the mail and found he had been sent to collections for her care.

23 Sep 2022

The successful transplantation of genetically engineered pig hearts into recently deceased humans

Researchers successfully transplanted two genetically engineered heart pigs into recently deceased humans in June and July 2022.

14 Jul 2022

Atrial fenestration during atrioventricular septal defect repair is linked to higher mortality rate

A new study, presented today at the AATS 101st Annual Meeting, shows an association between decreased survival at five years and leaving an atrial communication at biventricular repair of unbalanced AVSD after adjusting for other known risk factors.

3 May 2021

Surgery to correct congenital heart disease linked to increased risk of adult hypertension

In a medical records study covering thousands of children, a U.S.-Canadian team led by researchers at Johns Hopkins Medicine concludes that while surgery to correct congenital heart disease (CHD) within 10 years after birth may restore young hearts to healthy function, it also may be associated with an increased risk of hypertension -- high blood pressure -- within a few months or years after surgery.

8 Apr 2021

Research on genetic heart disease uncovers new mechanism for heart failure

Research on genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.

19 Nov 2020

New tool can encourage more hospitals to be transparent about cardiac outcomes

Congenital Heart Disease (CHD) is the most common birth defect in the United States, occurring in approximately one in every 100 babies.

16 Oct 2020

Surgical treatment of breast asymmetry in young women provides psychosocial benefits

Nearly all women have breasts that are slightly different from each other. However, some women have more marked differences in the size, shape, or position of the breasts even after development is complete - leading to negative effects on emotional well-being and self-image.

24 Sep 2020

Study reports potential therapeutic target for lethal heart defect in children

When children are born with hypoplastic left heart syndrome (HLHS), they require a series of major surgical procedures to survive. But even with a repaired heart, as many as one in four children die from complications before age 25.

18 Aug 2020

Study shows home monitoring program improves survival rates in infants with heart defects

Interstage Home Monitoring (IHM) programs for infants with single ventricle heart defects help families recognize potential complications early and improve infant survival rates and growth prior to the second of multiple surgeries.

11 Aug 2020

New collaboration aims to provide solutions for patients with hypoplastic left heart syndrome

Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.

25 Nov 2019

Clinical study demonstrates potential of regenerative therapy for hypoplastic left heart syndrome

A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery.

24 Jul 2019