Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Review highlights essential neurological considerations for gender dysphoria care

Gender dysphoria involves distress caused by a mismatch between a person's gender identity and sex assigned at birth.

28 Oct 2026

Amyloid fibers help sperm deliver RNA to mouse embryos

Researchers identified RNA-associated amyloid fibrils in human seminal fluid and demonstrated that synthetic PAP fibrils could enter mammalian sperm. In mouse IVF experiments, these fibrils helped sperm deliver RNA to embryos, where the detected reporter-protein signal was at least tenfold higher than without fibril exposure.

27 Oct 2026

Mutant protein variant explains dominant inheritance of genetic immunodeficiency

New research shows how a mutant form of a protein named STAT3 causes a genetically dominant immunodeficiency.

27 Oct 2026

The vaginal microbiome may relate to more than reproductive health

Researchers analyzed vaginal microbiota, metabolites, and psychological questionnaire scores in 105 young Italian women and found associations between microbial community types and reward responsiveness, motivational drive, and behavioral inhibition. Exploratory models identified statistical links involving vaginal GABA and valine, but the cross-sectional study could not establish whether microbiome changes influence psychological functioning or the reverse.

26 Oct 2026

Clinical trial establishes effective HIV dosing regimen for full-term newborns

An international study conducted through the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network including researchers at the University of California San Diego helped inform the U.S. Food and Drug Administration's (FDA) recent approval of dolutegravir, a second-generation integrase inhibitor, for the treatment of human immunodeficiency virus (HIV-1) in newborns from birth.

22 Oct 2026

Disease outbreak experience alters food safety behaviors in macaque monkeys

In the early days of the COVID-19 pandemic, many households wiped down groceries with disinfectant before putting them away.

21 Oct 2026

Infections caused 1 in 8 cancer cases worldwide in 2024, study finds

Infections drove 1 in 8 cancer cases worldwide in 2024, study finds.

9 Oct 2026

Pneumococcal disease may signal undiagnosed blood cancer

Severe pneumococcal disease requiring hospitalization, most commonly pneumonia, can be a sign of previously undiagnosed blood cancer and immunodeficiency in adult patients, according to a study from the University of Gothenburg.

30 Sep 2026

HIV awareness emphasizes prevention, treatment and healthy aging

About 1.2 million people in the United States are living with HIV, or human immunodeficiency virus. Because of major advances in medical treatment and technology, people with HIV are living long, healthy lives.

18 Sep 2026

Persistent stigma creates barriers to modern HIV prevention methods

For decades, HIV (human immunodeficiency virus) has been surrounded by fear, misinformation and stigma.

18 Sep 2026

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Researchers created xenocortical mice by transplanting human cortical organoids into animals genetically depleted of much of their native cortex, allowing the human tissue to occupy most of the available cortical space and form anatomical connections throughout the host nervous system. The grafts developed diverse cortical cell types, including L5-ET and VEN-like neurons, generated organized neural activity, and produced measurable cellular and behavioral responses to hypoxic injury.

18 Sep 2026

Male contraception has barely changed in a century. What comes next?

A review traces more than 5,000 years of male contraception, from early penile sheaths and the development of modern condoms and vasectomy to today's search for reversible alternatives. Researchers are now testing hormonal gels, non-hormonal compounds and vas-occlusive technologies, although these approaches remain at different stages of preclinical and clinical development.

15 Sep 2026

Cancer drug eliminates HIV-infected cells in animal model study

Emory University researchers have provided the first proof-of-concept in a nonhuman primate model for eliminating HIV-infected cells with venetoclax, a clinically approved medication for cancer.

3 Sep 2026

Mayo Clinic joins multi-million dollar gene-editing project for children

Mayo Clinic is a clinical collaborator on an award of up to $27.7 million from the Advanced Research Projects Agency for Health (ARPA-H) to help develop affordable, scalable gene-editing therapies for children with rare inherited immune disorders.

27 Aug 2026

Long-acting HIV prevention tools could help close the gap before a vaccine arrives

A review of non-vaccine HIV interventions highlights the strong preventive effects of long-acting PrEP, sustained ART, U=U, vertical transmission programs, and voluntary medical male circumcision. Gene editing and multispecific antibodies may expand future options, but safety, cost, access, adherence, and implementation barriers remain.

5 Aug 2026

Children remain more vulnerable to influenza despite protective antibody levels

Researchers analyzing 1,518 South African household participants found that higher pre-season antibody titers were associated with lower infection risk for three of four influenza viruses studied. Children remained more susceptible after accounting for measured exposure and antibody titers, while younger children shed viral RNA longer than older adults.

3 Aug 2026

Biotherapeutic metabolite repairs gut damage caused by HIV infection

Researchers at the UC Davis School of Medicine have identified a naturally occurring metabolite that repairs gut damage caused by HIV infection and significantly improves the effectiveness of antiretroviral therapy (ART) in the nonhuman primate model of HIV/AIDS.

30 Jul 2026

Dysregulation of immune regulator NF-κB drives major human diseases

NF‑κB controls genes involved in inflammation, immunity, cell survival, and proliferation. Triggered by cytokines (TNF‑α, IL‑1β), microbial products, or cellular stress, it translocates to the nucleus and induces pro‑inflammatory mediators.

13 Jul 2026

Study links semaglutide and tirzepatide to fewer anxiety and depression diagnoses in obesity care

A US electronic health record study found that adults with obesity who started semaglutide or tirzepatide had lower recorded hazards of anxiety and depression than matched patients using naltrexone-bupropion. However, among adults without type 2 diabetes, tirzepatide was linked to higher recorded hazards of anxiety and insomnia than semaglutide, underscoring the need for cautious monitoring.

1 Jul 2026

Pioneering gene therapy for rare immune disorder shows promise in early pre-clinical studies

The development of a pioneering gene therapy to treat a devastating, rare immune disorder led by UCL scientists is set to move into its next phase following promising early pre-clinical studies.

27 Jun 2026