Mesenchyme News and Research

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Researchers uncover molecular pathway driving craniosynostosis

Craniosynostosis is a congenital developmental disorder in which the skull's cranial sutures fuse prematurely.

28 Aug 2026

Study reveals molecular control of tooth root formation and growth

Tooth root development relies on precise coordination of cellular signals, yet the underlying mechanisms remain unclear. Researchers have uncovered how two proteins, Gli2 and Gli3, work together to control signaling and differentiation in dental progenitor cells.

1 Apr 2026

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

The interaction between genetics and tissue environment shapes how individual teeth form in different regions of the jaw.

12 Dec 2025

Discovering the role of lingual and buccal cells in tooth development

A novel study on the natural coordination of tooth development in time and space, led by Dr. Han-Sung Jung at the Yonsei University College of Dentistry, Korea, has discovered that "lingual" cells on the side of the tongue form the tooth, whereas those toward the cheek, called "buccal cells," form the bones and gums, guided by signaling molecules like WNT and BMP.

24 Oct 2025

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.

5 Aug 2025

Blocking a single enzyme rewires limb regrowth in axolotls

Researchers uncovered how CYP26B1-mediated retinoic acid (RA) breakdown determines segment identity during axolotl limb regeneration. Disrupting RA degradation reprograms blastema cells, revealing the molecular controls of precise limb regrowth.

11 Jun 2025

Advanced organoid model recreates complex liver architecture

The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct in the liver periportal region.

29 May 2025

Neanderthal legacy: The surprising genetics behind human tooth size

A recent study identifies key genetic factors—PITX2 expression and Neanderthal-introgressed HS3ST3A1—that contribute to variations in tooth size among modern human populations, especially highlighting differences across ancestries.

17 Dec 2024

Research reveals role of IGFBP3 in human lung development

Researchers of the University of Barcelona and the August Pi y Sunyer Biomedical Research Institute (IDIBAPS) have shown that the IGFBP3 protein plays a relevant role in human lung development.

1 Nov 2024

New study reveals how colorectal cancer cells establish liver metastases

Researchers at ETH Zurich have uncovered how colorectal cancer cells colonize the liver. Their findings could open up new ways to suppress this process in the future.

29 Jul 2024

Study unveils key mechanisms behind colorectal cancer metastasis to the liver

In cases where cancer is fatal, nine out of ten times the culprit is metastasis.

24 Jul 2024

Mechanical pressure revealed as key factor in embryonic organ formation

A collaboration between research groups at the University of California, TU Dresden in Germany and Cedars-Sinai Guerin Children's in Los Angeles has identified a mechanism by which embryonic cells organize themselves to send signals to surrounding cells, telling them where to go and what to do.

3 Apr 2024