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Compound YZG-331 leverages gut microbiota to improve sleep in mouse models of insomnia

This new article publication from Acta Pharmaceutica Sinica B discusses how interactions between the investigational compound YZG-331 and the gut microbiota contribute to its sleep-promoting effects in mouse models of insomnia.

5 Nov 2026

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

Blood may reveal signs of gut-related disease that stool samples miss

In a study of 193 participants, researchers found that blood-based short-chain fatty acid profiles distinguished colorectal cancer, celiac disease, obesity, and healthy controls with 95% accuracy, compared with 59% for stool-based measurements. Combining blood and stool profiles increased accuracy to 97%, suggesting that circulating microbial metabolites may offer valuable diagnostic information, although larger studies are needed to validate the findings.

3 Nov 2026

Compounds that give citrus fruits their scent may affect gut health

A review published in Food & Function found that dietary terpenoids, naturally occurring compounds in fruits, herbs, and vegetables, can suppress inflammatory signalling and improve intestinal barrier function in laboratory and animal studies. However, human evidence remains limited to two small studies of geraniol-based interventions for irritable bowel syndrome, with further research needed to establish clinical efficacy, appropriate dosing, and long-term safety.

3 Nov 2026

Blueberries reduced blood vessel inflammation in mice, but only with gut microbes present

A preclinical study found that gut microbes help convert blueberry phytochemicals into circulating metabolites, including hippuric acid, that are associated with reduced vascular inflammation. In mice fed a high-fat diet, blueberry supplementation reduced inflammatory markers and monocyte adhesion to blood vessels, but these benefits disappeared following antibiotic-mediated gut microbial depletion.

3 Nov 2026

New international initiative explores how energy shapes brain function

Professor Tim Vogels from the Institute of Science and Technology Austria (ISTA) will receive $3 million as part of an ambitious new $80 million international research initiative exploring how energy shapes brain function.

2 Nov 2026

Reducing opioid medication during pregnancy may not ease neonatal opioid withdrawal syndrome

Pregnant patients receiving medication to treat opioid use disorder should not reduce their medication dose out of fear that it will worsen withdrawal symptoms in their newborns, according to a new study led by researchers at the University of Maryland School of Medicine (UMSOM).

30 Oct 2026

Mayo Clinic enters new medical era with precure research

Mayo Clinic researchers are uncovering the earliest shifts in disease biology - long before symptoms appear - revealing how disease takes root and opening new possibilities to identify, predict and potentially prevent disease before symptoms develop.

30 Oct 2026

Amino acid restores power to last-resort antibiotics

Worldwide, antibiotic resistance is associated with millions of deaths every year, and the World Health Organization warns that the number of resistant infections is rising.

29 Oct 2026

Vitamin B5 derivative pantethine helps prevent and alleviate psoriasis symptoms in mice

Researchers in China have discovered that the vitamin B5 derivative pantethine limits the activity of immune cells that are key contributors to autoimmune diseases such as psoriasis.

27 Oct 2026

The vaginal microbiome may relate to more than reproductive health

Researchers analyzed vaginal microbiota, metabolites, and psychological questionnaire scores in 105 young Italian women and found associations between microbial community types and reward responsiveness, motivational drive, and behavioral inhibition. Exploratory models identified statistical links involving vaginal GABA and valine, but the cross-sectional study could not establish whether microbiome changes influence psychological functioning or the reverse.

26 Oct 2026

Researchers harness cancer cells' carbon monoxide to produce anticancer drug

What if we could use a cancer's own byproduct to make drugs that destroy tumor cells from the inside? That is exactly what Katsunori Tanaka and his team have done at the RIKEN Pioneering Research Institute (PRI) in Japan.

23 Oct 2026

Maximizing bioprocess efficiency through real-time cell density monitoring

Discover how real-time cell density monitoring boosts yield, lowers media costs, and improves viability in bioprocessing.

From Hamilton AG 21 Oct 2026

Greenwood Genetic Center researcher wins major grant to explore cellular metabolism and glycosylation

Heather Flanagan-Steet, PhD, Associate Director of Research at the Greenwood Genetic Center (GGC), has received a $1.4 million, five-year Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institutes of Health's National Institute of General Medical Sciences.

21 Oct 2026

Scientists found a link between Mediterranean diet blood markers and longer survival

Researchers found that a previously validated 67-metabolite blood signature of Mediterranean diet adherence was associated with lower long-term mortality across a Spanish trial population and three US cohorts. Participants with the highest signature scores had a 23% lower relative hazard of death than those with the lowest scores in both populations, although the findings do not establish a causal relationship.

20 Oct 2026

Cannabis smokers may need more anesthesia during upper endoscopy

Patients who smoke or vape cannabis may need more anesthesia during an upper endoscopy than those who use edibles or do not use cannabis, according to a new study presented at the ANESTHESIOLOGY® 2026 annual meeting.

19 Oct 2026

Your age may not tell the whole story about your health, but your blood could

Researchers analyzed plasma metabolites from 18,476 individuals aged 1 to 96 years and developed two metabolomic aging measures to assess biological aging, chronic disease, and mortality risk. Accelerated metabolomic aging was associated with greater risks of chronic disease and death, while a separate mortality-linked measure provided additional information about health status and disease burden beyond conventional clinical assessments.

18 Oct 2026

Study identifies priority genes for safer prescribing in older Chinese patients

A research team has identified three genes that could help prioritize pharmacogenomic testing for older adults in China who receive multiple medications.

15 Oct 2026

E. coli eavesdrops on neighboring bacteria to stabilize gut diversity

The stability of the human gut microbiome relies on interactions between different bacterial species. However, the specific molecular mechanisms of these interactions, particularly among non-dominant species, remain largely unexplored.

14 Oct 2026

Coffee, citrus and genetics: What scientists found inside human breast milk

In a bioRxiv preprint, researchers analyzed 458 metabolites in breast milk samples from 349 mothers to investigate how maternal diet, genetics, clinical characteristics, and milk-cell gene expression relate to milk composition. Maternal diet explained the greatest share of metabolite variation among the measured maternal factors, while specific genetic variants and gene-expression patterns were associated with individual metabolites, although the study did not establish effects on infant health.

14 Oct 2026

Metabolites News and Research

Compound YZG-331 leverages gut microbiota to improve sleep in mouse models of insomnia

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

Blood may reveal signs of gut-related disease that stool samples miss

Compounds that give citrus fruits their scent may affect gut health

Blueberries reduced blood vessel inflammation in mice, but only with gut microbes present

New international initiative explores how energy shapes brain function

Reducing opioid medication during pregnancy may not ease neonatal opioid withdrawal syndrome

Mayo Clinic enters new medical era with precure research

Amino acid restores power to last-resort antibiotics

Vitamin B5 derivative pantethine helps prevent and alleviate psoriasis symptoms in mice

The vaginal microbiome may relate to more than reproductive health

Researchers harness cancer cells' carbon monoxide to produce anticancer drug

Maximizing bioprocess efficiency through real-time cell density monitoring

Greenwood Genetic Center researcher wins major grant to explore cellular metabolism and glycosylation

Scientists found a link between Mediterranean diet blood markers and longer survival

Cannabis smokers may need more anesthesia during upper endoscopy

Your age may not tell the whole story about your health, but your blood could

Study identifies priority genes for safer prescribing in older Chinese patients

E. coli eavesdrops on neighboring bacteria to stabilize gut diversity

Coffee, citrus and genetics: What scientists found inside human breast milk

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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