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New covalent inhibitor targets DNAJC9 to reduce sepsis inflammation

This new article publication from Acta Pharmaceutica Sinica B discusses the discovery of the covalent inhibitor A12 and the identification of DNAJC9 as a potential drug target for sepsis-associated inflammation.

5 Nov 2026

Modified zinc finger scaffold suppresses microglial activation in mouse brain

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease. The approach also reduced the toxicity of protein aggregates that had already formed.

5 Nov 2026

New nanovesicle therapy shows promise for treating alcohol-related liver disease

Alcohol-related liver disease (ALD) is characterized by hepatocellular injury, oxidative stress, inflammation, and extracellular matrix remodeling, yet effective therapies remain limited.

4 Nov 2026

Nanoscale particle shows potential as customizable delivery vehicle for personalized cancer vaccines

A nanoscale particle with a unique structure, developed at MIT, holds potential as a customizable delivery vehicle for personalized cancer vaccines.

30 Oct 2026

High-fat diets in mouse parents alter offspring brain development

Researchers fed breeding pairs of mice five diets with different fat and sugar contents to examine how parental nutrition affects offspring brain development. High-fat diets, alone or combined with high sugar, delayed early motor development and altered brain structure in young adult offspring, while the high-sugar-only diet produced no significant changes in individual brain regions after correction for multiple comparisons.

28 Oct 2026

Early exercise improves motor function in a mouse model of DDX3X syndrome

Acquisition of motor skills during infancy is critical for a child's ability to interact with the physical and social environment and motor impairments are frequent in individuals with neurodevelopmental disorders, including autism.

27 Oct 2026

Six-gene score could improve survival predictions for acute myeloid leukemia

The activity of six different genes can help determine patient survival of acute myeloid leukemia (AML), according to a study published today in Science Advances.

23 Oct 2026

Researchers identify molecular target to improve pancreatic cancer treatment

Pancreatic cancer is one of the most aggressive and difficult-to-treat cancers. One reason for its resistance to therapy is the dense tissue surrounding the tumor, which acts as a protective barrier and suppresses the immune response.

23 Oct 2026

Unstable immune cells linked to severe cancer immunotherapy side effects

Scientists at the University of Pittsburgh uncovered the unstable immune cells that can cause up to 40% of immunotherapy patients to experience serious side effects and showed that diet and microbiome composition influence the side effect's severity.

22 Oct 2026

Prenatal iron deficiency linked to lasting changes in the offspring brain

During the first weeks of pregnancy, developing cells are already laying the foundation for the brain. Iron plays a major role in the organization and shaping of cells during this stage of gestation.

21 Oct 2026

Blocking specific proteins protects beta cells om excessive cellular stress

Researchers at Weill Cornell Medicine have identified a molecular pathway that contributes to the death of insulin-producing beta cells in the pancreas.

21 Oct 2026

Combination approach slows osteosarcoma growth and prolongs survival in preclinical models

Scientists co-led by St. Jude Children's Research Hospital have identified a potential therapeutic vulnerability in some forms of osteosarcoma.

20 Oct 2026

Scientists discover immune pathway behind radiation-induced lung damage

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, have uncovered an immune pathway that may contribute to radiation-related lung damage and have identified a potential strategy to block it.

20 Oct 2026